КОРРЕКЦИЯ ИММУННОГО БЕСПЛОДИЯ У МУЖЧИН МЕТОДАМИ ЭФФЕРЕНТНОЙ ТЕРАПИИ

Аннотация

Effects of plasmapheresis and hemosorption on efficacy of the
treatment of autoimmune male infertility (AMI) were studied in 289
AMI males with oligoasthenozoospermia aged 19 to 37 years. The
males were divided into three groups by the levels of antisperm antibodies
(ASAB) in the blood and ejaculate. The study was made of
cellular and humoral immunity, intensity of protein and lipid free radical
oxidation and antioxidant defense. Patients of group 1 with high
ASAB in the blood but low in ejaculate received a course of plasmapheresis.
Patients of group 2 with high ASAB both in the blood
and ejaculate were subjected to hemosorption and plasmapheresis in
one contour. Group 3 patients with high ASAB in ejaculate but low
in the blood received efferent therapy only after medication and photomodification
of the blood. The treatment reduced elevated levels of
ASAB in the blood and ejaculate, normalized free radical oxidation,
cellular and humoral immunity, antioxidant defense. This resulted in
improvement of spermogram parameters, efficacy of assisted reproductive
technologies, higher probability of natural pregnancy in the
patients' wives.