SEXUAL DEVELOPMENT OF BOYS WITH HYPOSPADIAS


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The article presents the results of a clinical evaluation of 39 boys with hypospadias aged 10—15 years. The examination included clinical assessment of pubertal development, and Doppler ultrasound scan of the gonads, transrectal ultrasound of the prostate in adolescents over 14 years, the definition of serum levels of gonadotropins, sex steroids and inhibin B. Puberty in boys with hypospadias is characterized by later appearance of pubarhe, microphallus, lack of testicular blood flow, and hypotrophy of the prostate. Statistically significant difference in sexual development of boys with penile and scrotal hypospadias was detected. On the basis of the hormonal examination, a violation of function of Sertoli cells in 43% of boys with the penile hypospadias and in 68% with scrotal hypospadias was identified. Leydig cell dysfunction was not found.

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Әдебиет тізімі

  1. Achermann J.C., Hughes I.A. Disorders of sex development / in Kronenberg HM, Melmed S, Polonsk K.S., Larsen P.R. (eds): Williams Textbook of Endocrinology, ed 11. Philadelphia, Saunders. 2008;783—848.
  2. Baskin L.S, Ebbers M.B. Hypospadias: anatomy, etiology, and technique. J. Pediatr. Surgery. 2007;41:463—472.
  3. Houk C.P., Hughes IA, Ahmed F.S. et al. Consensus Statement on Management of Intersex Disorders. Pediatrics. 2006;118(2):753— 758.
  4. Aaronson I.A., Cakmak M.A., Key L.L. Defects of the testosterone biosynthetic pathway in boys with hypospadias. J. Urol. 1997;157(5):1884—1888.
  5. Меновщикова Л.Б., Коварский С.Л., Калинченко Н.Ю. и др. эндокринные аспекти лечения гипоспадии у детей. Андрология и генитальная хирургия. 2010;3:84—89.
  6. Feyaerts A., Forest M.G. et al. Endocrine screening in 32 consecutive patients with hypospadias. J. Urol. 2002;168(2):720—725.
  7. Holmes N.M., Miller W.L, Baskin L.S. Lack of defects in androgen production in children with hypospadias. J. Clin. Endocrinol. Metab. 2004;89(6):2811—2816.
  8. Silver R.I., Russel D.W. 5-reductase type 2 mutations are present in some boys with isolated hypospadias. J. Urol. 1999;162:1142—1145.
  9. Elzanaty S., Giwercman Y.L., Giwercman A. Significant impact of 5alpha-reductase type 2 polymorphisms on sperm concentration and motility. Int. J. Androl. 2006;29:414—420.
  10. Fukami M., Wada Y. et al. CXorf6 is a causative gene for hypospadias. Nat. Genet. 2006;38:1369—1371.
  11. Ogata T., Laporte J., Fukami M. MAMLD1 (CXorf6): a new gene involved in hypospadias. Horm Res. 2009;71(5):245—252.
  12. Zanden L.F., Rooij I.A. et al. Aetiology of hypospadias: a systematic review of genes and environment. Human Reproduction. 2012;18(3):260—283.
  13. Hsieh M.H., Hollander A.B.S., Lamb D.J. et al. The Genetic and Phenotypic Basis of Infertility in Men with Pediatric Urologic Disorders. Urology. 2010;76(1):25—31.
  14. Burger H.G., Igarashi M. Inhibin: definition and nomenclature, including related substances. Endocrinology. 1988;122:1701—1702.
  15. Meachem S.J., Nieschlag E., Simoni M. Inhibin B in male reproduction: pathophysiology and clinical relevance. Eur. J. Endocrinol. 2001;145:561 —571.
  16. Пиков М.И., Филиппова Е.В. Нормальная эхографическая анатомия предстательной желези у детей и подростков. Репродуктивной здоровье детей и подростков. 2006;3:33—37.

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