REPRODUCTIVE FUNCTION IN MEN WITH CHRONIC PROSTATITIS: CLINICAL, DISEASE HISTORY AND MICROBIOLOGICAL RISK ASPECTS


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Abstract

Case records of 3174 men aged 20-45 years living in a heterosexual marriage and having a regular sexual life were analyzed. Examination of couples and sperm analysis was conducted in accordance with the requirements of the WHO. Leukocytospermia was present in 19% of infertile cases. In 54% of those cases chronic prostatitis was associated with aerobic bacterial infection, in 9% - with chlamydial and in 12% with urea- and mycoplasma. It was found that concentrations of leukocytes in semen and clinical symptoms (pain and dysuria) were not independent risk factors for infertility. Infertile patients had higher incident rates of E. coli (OR=4,1) and bacterial associations (OR=6,9) with reduced antimicrobial resistance of seminal plasma(for E. coli OR=9,9; for Ps. aeruginosa OR=6,0). Other risk factors for fertility reduction in patients with HP are the duration of the disease (OR=2,7), frequency of exacerbations (OR=2,6), presence of fibrosis and prostatolites (OR=1,8) and functional prostate-vesicular obstruction (OR=1,4). Further studies are needed to understand HP pathogenesis and explain the negative impact of HP on male fertility.

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About the authors

V. A. Bozhedomov

SBEI HPE «The Peoples' Friendship University of Russia»; SBEI HPE «First MSMU n.a. I.M. Sechenov»; FSBI «Polyclinic № 1of» of ABP of RF

Email: vbojedomov@maiI.ru
Department of Clinical Andrology; Prof, of Department of Obstetrics, Gynecology, Perinatology and Reproductive; Ph.D., Scientific Director of Andrology and Reproduction

A. V. Semenov

SBIH «Regional Clinical Hospital» Healthcare Department of Ivanov city

A. V. Konyshev

FSBI «Polyclinic № 1of» of ABP of RF

N. A. Lipatova

SBEI HPE «The Peoples' Friendship University of Russia»

G. M. Pacanovskaya

SBIH «Regional Clinical Hospital» Healthcare Department of Ivanov city

G. E. Bozhedomova

SBEI HPE «First MSMU n.a. I.M. Sechenov»

A. V. Tret'yakov

SBIH «City Polyclinic № 3» of Moscow Healthcare Department

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