Concerning selective neck dissections in oral squamous cell carcinoma

  • Authors: Alymov Y.V1, Podvyaznikov SO1, Mudunov AM2
  • Affiliations:
    1. Russian Medical Academy for Postgraduate Education of the Ministry of Health of the Russian Federation
    2. N.N.Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation
  • Issue: Vol 18, No 1 (2016)
  • Pages: 75-79
  • Section: Articles
  • URL: https://modernonco.orscience.ru/1815-1434/article/view/27056
  • Cite item

Abstract


Background. Incidence of oral cancer in Russia is 4.52 and mortality - 2.44. Head and neck cancer is characterized by the high risk of development of metastases in regional lymph nodes (LN). LN status exerts influence on the treatment plan and appears to be the major predictive factor. Regional metastases result into two-fold decrease of five-year survival. Treatment of metastatic LN is of prime importance.Objective. The aim of this manuscript was to illustrate and summarize publications devoted to selective neck dissections in patients with squamous cell carcinoma of the oral cavity (OC).Results. Classic radical neck dissection is the gold standard of surgical treatment of OC cancer, characterized by regional metastases. However, metastases in neck LN of the IV- and V-th level are rarely present in patients with oral cancer. Therefore, efficiency of less extensive neck surgery is of great interest of up-to-date investigations. It was established, that selective neck dissection increases disease-free survival among patients with cT1-4N0M0 oral cancer in comparison with watchful waiting. Comparison of preventive selective neck dissections with preventive and curative modified neck dissections also indicates, that these methods of surgical treatment have equal efficacy.Conclusion. Selective neck dissection is feasible treatment method of сT1-4N0M0 oral cancer. Nevertheless, comparison studies of preventive selective and modified neck dissections, were characterized by disparate design and high probability of systematic errors. Moreover, another aspect, that must be solved, is the number of LN levels to be dissected during selective neck dissection. Thus, conception of selective neck dissection in patients with clinically negative LN is changing and requires further investigation.

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About the authors

Yu V Alymov

Russian Medical Academy for Postgraduate Education of the Ministry of Health of the Russian Federation

Email: allmedperevod@gmail.com
125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1

S O Podvyaznikov

Russian Medical Academy for Postgraduate Education of the Ministry of Health of the Russian Federation

125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1

A M Mudunov

N.N.Blokhin Russian Cancer Research Center of the Ministry of Health of the Russian Federation

115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

References

  1. http://globocan.iarc.fr/Pages/Map.aspx
  2. Каприн А.Д., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2012 году (заболеваемость и смертность). М., 2014.
  3. Пачес А.И. Опухоли головы и шеи. М.: Медицина, 2001.
  4. Поддубная И.В. Онкология. Справочник практического врача. М.: МЕДпресс - информ, 2009; с. 162-3.
  5. Snow G.В, Patel P, Leemans C.R, Tiwari R. Management of cervical lymph nodes in patients with head and neck cancer. Eur Arch Otorhinolaryngol 1992; 249 (4): 187-94.
  6. Абузарова Г.Р., Алексеев Б.Я., Антипов В.А. и др. Онкология: клинические рекомендации. Под ред. В.И.Чиссова, С.Л.Дарьяловой. 2-е изд., испр. и доп. 2009; с. 154.
  7. Woolgar J.A, Triantafyllou A, Jr Lewis J.S et al. Prognostic biological features in neck dissection specimens. Eur Arch Otorhinolaryngol 2013; 270: 1581-92.
  8. Som P.M. Detection of metastasis in cervical lymph nodes: CT and MR criteria and differential diagnosis. Am J Roentgenol 1992; 158: 961.
  9. Robbins K.T, Medina J.E, Wolfe G.T et al. Standardizing neck dissection terminology. Official report of the academy’s committee for head and neck surgery and oncology. Arch Otolaryngol Head Neck Surg 1991; 117: 601-5.
  10. Bataini J.P, Bernier J, Brugere J et al. Natural history of neck disease in patients with squamous cell carcinoma of the oropharynx and pharyngolarynx. Radiother Oncol 1985; 3: 245-55.
  11. Shah J.P, Candela F.C, Poddar A.K. The patterns of cervical lymph node metastases from squamous carcinoma of the oral cavity. Cancer 1990; 66: 109-13.
  12. Романов И.С. Стратегия диагностики и лечения регионарных метастазов рака слизистой оболочки полости рта. М., 2013.
  13. Hamoir M, Schmitz S, Gregoire V. The Role of Neck Dissection in Squamous Cell Carcinoma of the Head and Neck. Springer Science 2014.
  14. Govers T.M, Hannink G, Merkx M.A et al. Sentinel node biopsy for squamous cell carcinoma of the oral cavity and oropharynx: a diagnostic meta - analysis. Oral Oncol 2013; 49: 726-32.
  15. Stoekli S.J, Pfalz M, Steinert H et al. Histopathological features of occultmetastasis detected by sentinel lymph node biopsy in oral and oropharyngeal squamous cell carcinoma. Laryngoscope 2002; 112: 111-5.
  16. Civantos F.J, Zitsch R.P, Schuller D.E et al. Sentinel lymph node biopsy accurately stages the regional lymph nodes for T1-T2 oral squamous cell carcinomas: results of a prospective multi - institutional trial. J Clin Oncol 2010; 28: 1395-400.
  17. Clayman G.L, Frank D.K. Selective neck dissection of anatomically appropriate levels is as efficacious as modified radical neck dissection for elective treatment of the clinically negative neck in patients with squamous cell carcinoma of the upper respiratory and digestive tracts. Arch Otolaryngol Head Neck Surg 1998; 124: 348-52.
  18. Byers R.M. Modified neck dissection. A study of 967 cases from1970 to 1980. Am J Surg 1985; 150: 414-21.
  19. Spiro J.D, Spiro R.H, Shah J.P et al. Critical assessment of supraomohyoid neck dissection. Am J Surg 1988; 156: 286-9.
  20. Byers R.M, Weber R.S, Andrews T et al. Frequency and therapeutic implications of “skip metastases” in the neck from squamous carcinoma of the oral tongue. Head Neck 1997; 19: 14-9.
  21. De Zinis L.O, Bolzoni A, Piazza C et al. Prevalence and localization of nodal metastases in squamous cell carcinoma of the oral cavity: role and extension of neck dissection. Eur Arch Otorhinolaryngol 2006; 263: 1131-5.
  22. Mishra P, Sharma A.K. A 3-year study of supraomohyoid neck dissection and modified radical neck dissection type I in oral cancer: with special reference to involvement of level IV node metastasis. Eur Arch Otorhinolaryngol 2010; 267: 933-8.
  23. St-John C, Hoffman A, Potts J, Fardy M.J. Reduction of occult metastatic disease by extension of the supraomohyoid neck dissection to include level IV, Wiley Periodicals, Inc. Head Neck 2003; 25: 758-62.
  24. Yu S, Li J, Li Z et al. Efficacy of supraomohyoid neck dissection in patients with oral squamous cell carcinoma and negative neck. Am J Surg 2006; 191: 94-9.
  25. Kligerman J, Lima R.A, Soares J.R et al. Supraomohyoid neck dissection in the treatment of T1/T2 squamous cell carcinoma of oral cavity. Am J Surg 1994; 168 (5): 391-4.
  26. Vandenbrouck C, Sancho-Garnier H, Chassagne D et al. Elective versus therapeutic radical neck dissection in epidermoid carcinoma of the oral cavity: results of a randomized clinical trial. Cancer 1980; 46 (2): 386-90.
  27. Fakih A.R, Rao R.S, Borges A.M, Patel A.R. Elective versus therapeutic neck dissection in early carcinoma of the oral tongue. Am J Surg 1989; 158 (4): 309-13.
  28. Guo C.B, Feng Z, Zhang J.G et al. Supraomohyoid neck dissection and modified radical neck dissection for clinically node - negative oral squamous cell carcinoma: A prospective study of prognosis, complications and quality of life. J Cranio-Maxillo-Facial Surg 2014; 42: 1885e1890.
  29. Kerawala C, Martin I.C. Extending the supraomohyoid neck dissection in squamous cell carcinoma of the floor of mouth [letter]. Head Neck 1998; 20: 434.
  30. Huang S-F, Kang C-J, Lin C-Y et al. Neck Treatment of Patients With Early Stage Oral Tongue Cancer. Comparison Between Observation, Supraomohyoid Dissection, and Extended Dissection. Cancer 2008; 112 (5).
  31. Sefik Hosal A, Carrau R.L, Johnson J.T, Myers E.N. Selective Neck Dissection in the Management of the Clinically Node-Negative Neck. Laryngoscope 2000; 110: 2037-40.

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