Anti-Cancer Agents in Medicinal ChemistryAnti-Cancer Agents in Medicinal ChemistryAnti-Cancer Agents in Medicinal Chemistry1871-52061875-5992Bentham Science64384010.2174/0118715206296523240424072939OncologyResearch ArticleCerium Oxide Nanoparticles Synthesis using Alhagi Maurorum Leaf Extract and Evaluation of Their Cytotoxic Effect on Breast Cancer Cell Lines and Antibacterial EffectsHosseiniSayedehinfo@benthamscience.netKhatamiMehrdadinfo@benthamscience.netAsadollahiAmirkianinfo@benthamscience.netYaghoobiHajarinfo@benthamscience.netDepartment of Medical Biotechnology, School of Advanced Technology, Shahrekord University of Medical SciencesDepartment of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares UniversityStudent Research Committee, Shahrekord University of Medical SciencesClinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences1507202424141056106207012025Copyright ©; 2024, Bentham Science Publishers2024Bentham Science Publishershttps://journals.eco-vector.com/1871-5206/article/view/643840

Introduction:Green synthesis offers a fast, simple, and economical method for producing metallic nanoparticles.The basis of this method is to obtain nanoparticles using natural materials, such as plants, fungi, and bacteria, instead of harmful and expensive chemical-reducing agents. In this study, CeO2NPs were produced using Alhagi maurorum extract, and their anticancer and antibacterial activities were evaluated.

Methods:Alhagi maurorum extract was prepared according to a previously described protocol, and CeO2NPs were synthesized from the salt of this extract. The resulting nanoparticles were characterized using Transmission electron microscopy (TEM), scanning electron microscope (SEM), and X-ray diffraction (XRD) techniques. The antibacterial and cytotoxic effects of the nanoparticles were measured by MIC, MBC, and MTT assays, respectively. The results were analyzed using one-way analysis of variance (ANOVA) using Prism software.

Results:The MTT assay on breast cancer cell lines showed that the cytotoxic effect of CeO2NPs on cell lines was concentration-dependent. In addition, this nanoparticle was more effective against Gram-positive bacteria.

Conclusion:These nanoparticles can be used as cancer drug delivery systems with specific targeting at low concentrations in addition to anticancer treatments. It can also have biological and medicinal applications, such as natural food preservation and wound dressing.

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