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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Anti-Cancer Agents in Medicinal Chemistry</journal-id><journal-title-group><journal-title xml:lang="en">Anti-Cancer Agents in Medicinal Chemistry</journal-title><trans-title-group xml:lang="ru"><trans-title>Anti-Cancer Agents in Medicinal Chemistry</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1871-5206</issn><issn publication-format="electronic">1875-5992</issn><publisher><publisher-name xml:lang="en">Bentham Science</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">644284</article-id><article-id pub-id-type="doi">10.2174/0118715206289468240130051102</article-id><article-categories><subj-group subj-group-type="toc-heading"><subject>Oncology</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Cervical Cancer Therapeutics: An In-depth Significance of Herbal and Chemical Approaches of Nanoparticles</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Saraswat</surname><given-names>Istuti</given-names></name><email>info@benthamscience.net</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Goel</surname><given-names>Anjana</given-names></name><email>info@benthamscience.net</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff id="aff1"><institution>Department of Biotechnology, GLA University</institution></aff><aff id="aff2"><institution>Department of Biotechnology,, GLA University</institution></aff><pub-date date-type="pub" iso-8601-date="2024-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2024</year></pub-date><volume>24</volume><issue>8</issue><issue-title xml:lang="ru"/><fpage>627</fpage><lpage>636</lpage><history><date date-type="received" iso-8601-date="2025-01-07"><day>07</day><month>01</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Bentham Science Publishers</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Bentham Science Publishers</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://journals.eco-vector.com/1871-5206/article/view/644284">https://journals.eco-vector.com/1871-5206/article/view/644284</self-uri><abstract xml:lang="en"><p id="idm46041443494064">Cervical cancer emerges as a prominent health issue, demanding attention on a global level for women's well-being, which frequently calls for more specialized and efficient treatment alternatives. Traditional therapies may have limited tumour targeting and adverse side effects. Recent breakthroughs have induced a transformative shift in the strategies employed against cervical cancer. biocompatible herbal nanoparticles and metallic particles made of gold, silver, and iron have become promising friends in the effort to fight against this serious disease and understand the possibility of these nanoparticles for targeted medication administration. this review article delves into the latest advancements in cervical cancer research. The safety and fabrication of these nanomaterials and their remarkable efficacy against cervical tumour spots are addressed. This review study, in short, provides an extensive introduction to the fascinating field of metallic and herbal nanoparticles in cervical cancer treatment. The information that has been examined points to a bright future in which women with cervical cancer may experience fewer side effects, more effective therapy, and an improved quality of life. This review holds promise and has the potential to fundamentally reshape the future of cervical cancer treatment by addressing urgent issues and unmet needs in the field.</p></abstract><kwd-group xml:lang="en"><kwd>Cervical cancer</kwd><kwd>metallic nanoparticles</kwd><kwd>gold nanoparticles</kwd><kwd>silver nanoparticles</kwd><kwd>iron nanoparticles</kwd><kwd>novel drug delivery systems.</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Cabral, B.P.; da Graça, D.F.M.; Mota, F.B. The recent landscape of cancer research worldwide: A bibliometric and network analysis. Oncotarget, 2018, 9(55), 30474-30484. doi: 10.18632/oncotarget.25730 PMID: 30093962</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Wu, M.S.; Aquino, L.B.B.; Barbaza, M.Y.U.; Hsieh, C.L.; De Castro-Cruz, K.A.; Yang, L.L.; Tsai, P.W. Anti-inflammatory and anticancer properties of bioactive compounds from Sesamum indicum L.A review. Molecules, 2019, 24(24), 4426. doi: 10.3390/molecules24244426 PMID: 31817084</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Debela, D.T.; Muzazu, S.G.Y.; Heraro, K.D.; Ndalama, M.T.; Mesele, B.W.; Haile, D.C.; Kitui, S.K.; Manyazewal, T. New approaches and procedures for cancer treatment: Current perspectives. SAGE Open Med., 2021, 9. doi: 10.1177/20503121211034366 PMID: 34408877</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Giana, F.E.; Bonetto, F.J.; Bellotti, M.I. Assay based on electrical impedance spectroscopy to discriminate between normal and cancerous mammalian cells. Phys. Rev. E, 2018, 97(3), 032410. doi: 10.1103/PhysRevE.97.032410 PMID: 29776129</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Siegel, R.L.; Miller, K.D.; Wagle, N.S.; Jemal, A. Cancer statistics, 2023. CA Cancer J. Clin., 2023, 73(1), 17-48. doi: 10.3322/caac.21763 PMID: 36633525</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Ferlay, J.; Colombet, M.; Soerjomataram, I.; Parkin, D.M.; Piñeros, M.; Znaor, A.; Bray, F. Cancer statistics for the year 2020: An overview. Int. J. Cancer, 2021, 149(4), 778-789. doi: 10.1002/ijc.33588 PMID: 33818764</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Sathishkumar, K.; Chaturvedi, M.; Das, P.; Stephen, S.; Mathur, P. Cancer incidence estimates for 2022 &amp; projection for 2025: Result from national cancer registry programme, India. Indian J. Med. Res., 2022, 156(4&amp;5), 598-607. PMID: 36510887</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Mathur, P.; Sathishkumar, K.; Chaturvedi, M.; Das, P.; Sudarshan, K.L.; Santhappan, S.; Nallasamy, V.; John, A.; Narasimhan, S.; Roselind, F.S. Cancer statistics, 2020: Report from national cancer registry programme, India. JCO Glob. Oncol., 2020, 6(6), 1063-1075. doi: 10.1200/GO.20.00122 PMID: 32673076</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Vaccarella, S.; Laversanne, M.; Ferlay, J.; Bray, F. Cervical cancer in Africa, Latin America and the Caribbean and Asia: Regional inequalities and changing trends. Int. J. Cancer, 2017, 141(10), 1997-2001. doi: 10.1002/ijc.30901 PMID: 28734013</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Zhang, S.; Xu, H.; Zhang, L.; Qiao, Y. Cervical cancer: Epidemiology, risk factors and screening. Chin. J. Cancer Res., 2020, 32(6), 720-728. doi: 10.21147/j.issn.1000-9604.2020.06.05 PMID: 33446995</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Brüggmann, D.; Quinkert-Schmolke, K.; Jaque, J.M.; Quarcoo, D.; Bohlmann, M.K.; Klingelhöfer, D.; Groneberg, D.A. Global cervical cancer research: A scientometric density equalizing mapping and socioeconomic analysis. PLoS One, 2022, 17(1), e0261503. doi: 10.1371/journal.pone.0261503 PMID: 34990465</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Castle, P.E.; Einstein, M.H.; Sahasrabuddhe, V.V. Cervical cancer prevention and control in women living with human immunodeficiency virus. CA Cancer J. Clin., 2021, 71(6), 505-526. doi: 10.3322/caac.21696 PMID: 34499351</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Cohen, P.A.; Jhingran, A.; Oaknin, A.; Denny, L. Cervical cancer. Lancet, 2019, 393(10167), 169-182. doi: 10.1016/S0140-6736(18)32470-X PMID: 30638582</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Cubie, H.A.; Campbell, C. Cervical cancer screening  The challenges of complete pathways of care in low-income countries: Focus on Malawi. Womens Health, 2020, 16, 1745506520914804. doi: 10.1177/1745506520914804 PMID: 32364058</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Lechner, M.; Liu, J.; Masterson, L.; Fenton, T.R. HPV-associated oropharyngeal cancer: Epidemiology, molecular biology and clinical management. Nat. Rev. Clin. Oncol., 2022, 19(5), 306-327. doi: 10.1038/s41571-022-00603-7 PMID: 35105976</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Namdari, M.; Eatemadi, A.; Soleimaninejad, M.; Hammed, A.T. A brief review on the application of nanoparticle enclosed herbal medicine for the treatment of infective endocarditis. Biomed. Pharmacother., 2017, 87, 321-331. doi: 10.1016/j.biopha.2016.12.099 PMID: 28064105</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Shafey, A.M.E. Green synthesis of metal and metal oxide nanoparticles from plant leaf extracts and their applications: A review. Green Proc. Syn., 2020, 9(1), 304-339. doi: 10.1515/gps-2020-0031</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Gorain, B.; Pandey, M.; Leng, N.H.; Yan, C.W.; Nie, K.W.; Kaur, S.J.; Marshall, V.; Sisinthy, S.P.; Panneerselvam, J.; Molugulu, N.; Kesharwani, P.; Choudhury, H. Advanced drug delivery systems containing herbal components for wound healing. Int. J. Pharm., 2022, 617, 121617. doi: 10.1016/j.ijpharm.2022.121617 PMID: 35218900</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Chavda, V.P.; Patel, A.B.; Mistry, K.J.; Suthar, S.F.; Wu, Z.X.; Chen, Z.S.; Hou, K. Nano-drug delivery systems entrapping natural bioactive compounds for cancer: Recent progress and future challenges. Front. Oncol., 2022, 12, 867655. doi: 10.3389/fonc.2022.867655 PMID: 35425710</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Tiwari, R.; Latheef, S.K.; Ahmed, I.; Iqbal, H.M.N.; Bule, M.H.; Dhama, K.; Samad, H.A.; Karthik, K.; Alagawany, M.; El-Hack, M.E.A.; Yatoo, M.I.; Farag, M.R. Herbal immunomodulators-a remedial panacea for designing and developing effective drugs and medicines: current scenario and future prospects. Curr. Drug Metab., 2018, 19(3), 264-301. doi: 10.2174/1389200219666180129125436 PMID: 29380694</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Martínez, R.C.J.; Tarhini, M.; Badri, W.; Miladi, K.; Greige-Gerges, H.; Nazari, Q.A.; Galindo, R.S.A.; Román, R.Á.; Fessi, H.; Elaissari, A. Nanoprecipitation process: From encapsulation to drug delivery. Int. J. Pharm., 2017, 532(1), 66-81. doi: 10.1016/j.ijpharm.2017.08.064 PMID: 28801107</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Jalili, A.; Bagherifar, R.; Nokhodchi, A.; Conway, B.; Javadzadeh, Y. Current advances in nanotechnology-mediated delivery of herbal and plant-derived medicines. Adv. Pharm. Bull., 2023, 13(4), 712-722. doi: 10.34172/apb.2023.087 PMID: 38022806</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Rodrigues, F.C.; Devi, N.G.; Thakur, G. Role of targeted drug delivery in cancer therapeutics. In: Advances and Challenges in Pharmaceutical Technology; , 2021; p. 327-354. doi: 10.1016/B978-0-12-820043-8.00008-6</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Gujar, K.; Wairkar, S. Nanocrystal technology for improving therapeutic efficacy of flavonoids. Phytomedicine, 2020, 71, 153240. doi: 10.1016/j.phymed.2020.153240 PMID: 32450461</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Shruthi, V. Formulation and charecterization of artemisinin nanoparticles doctoral dissertation. Jaya College of Paramedical Sciences; Thiruninravur, Chennai, 2019.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Takke, A.; Shende, P. Nanotherapeutic silibinin: An insight of phytomedicine in healthcare reformation. Nanomedicine, 2019, 21, 102057. doi: 10.1016/j.nano.2019.102057 PMID: 31340181</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Paul, A.T.; Jindal, A. Nano-natural products as anticancer agents. Anticancer Plants: Clinical Trials and Nanotec., 2017, 3, 27-50.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Zafar, S.; Jain, G.K.; Ahmad, F.J. Nanomedicine approaches for the delivery of herbal anticancer drugs. Nanomed. Bioactives: Healthcare Appl., 2020, 201-229.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Patil, A.V. Development and characterization of nanoparticulate formulations of water-insoluble anticancer drug. In: Doctoral dissertation; Rajiv Gandhi University of Health Sciences India, 2011.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Noor, N.S.; Kaus, N.H.M.; Szewczuk, M.R.; Hamid, S.B.S. Formulation, characterization and cytotoxicity effects of novel thymoquinone-PLGA-PF68 nanoparticles. Int. J. Mol. Sci., 2021, 22(17), 9420. doi: 10.3390/ijms22179420 PMID: 34502328</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Mathur, M. Achievements, constraints and gaps of nano-techniques per tains to augmenting herbal drug efficacy. Medicinal Plants  Int. J. Phytomed. Related Industries, 2016, 8(3), 171-198. doi: 10.5958/0975-6892.2016.00031.9</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Jahangir, M.A.; Zafar, A.; Khan, S.; Kala, C.; Muheem, A.; Taleuzzaman, M. Phytonutrients and technological development in formulations. J. Pharm. Res. Sci. Tech., 2022, 6(1), 38-66. doi: 10.31531/jprst.1000159</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Murthy, K.C.; Monika, P.; Jayaprakasha, G.K.; Patil, B.S. Nanoencapsulation: An advanced nanotechnological approach to enhance the biological efficacy of curcumin. American Chemical Society, In Advances in plant Phenolics: From chemistry to human health, 2018, 383-405.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Sharma, S.; Hafeez, A.; Usmani, S.A. Nanoformulation approaches of naringenin- an updated review on leveraging pharmaceutical and preclinical attributes from the bioactive. J. Drug Deliv. Sci. Technol., 2022, 76, 103724. doi: 10.1016/j.jddst.2022.103724</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Gajbhiye, K.R.; Salve, R.; Narwade, M.; Sheikh, A.; Kesharwani, P.; Gajbhiye, V. Lipid polymer hybrid nanoparticles: A custom-tailored next-generation approach for cancer therapeutics. Mol. Cancer, 2023, 22(1), 160. doi: 10.1186/s12943-023-01849-0 PMID: 37784179</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Rajpoot, K. Solid lipid nanoparticles: A promising nanomaterial in drug delivery. Curr. Pharm. Des., 2019, 25(37), 3943-3959. doi: 10.2174/1381612825666190903155321 PMID: 31481000</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Parmar, G.R.; Sailor, G.U. Nanotechnological approach for design and delivery of phytopharmaceuticals. Nanocarriers: Drug Delivery System: An Evidence Based Approach, 2021, 281-301.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Saraf, S.; Gupta, A.; Alexander, A.; Khan, J.; Jangde, M.; Saraf, S. Advancements and avenues in nanophytomedicines for better pharmacological responses. J. Nanosci. Nanotechnol., 2015, 15(6), 4070-4079. doi: 10.1166/jnn.2015.10333 PMID: 26369014</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Li, Z.; Zheng, W.; Wang, H.; Cheng, Y.; Fang, Y.; Wu, F.; Sun, G.; Sun, G.; Lv, C.; Hui, B. Application of animal models in cancer research: Recent progress and future prospects. Cancer Manag. Res., 2021, 13, 2455-2475. doi: 10.2147/CMAR.S302565 PMID: 33758544</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Blidisel, A.; Marcovici, I.; Coricovac, D.; Hut, F.; Dehelean, C.A.; Cretu, O.M. Experimental models of hepatocellular carcinoma. Cancers, 2021, 13(15), 3651. doi: 10.3390/cancers13153651 PMID: 34359553</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Gaspar, T.B.; Lopes, J.M.; Soares, P.; Vinagre, J. An update on genetically engineered mouse models of pancreatic neuroendocrine neoplasms. Endocr. Relat. Cancer, 2022, 29(12), R191-R208. doi: 10.1530/ERC-22-0166 PMID: 36197786</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Sur, S.; Ray, R.B. Bitter melon (momordica charantia), a nutraceutical approach for cancer prevention and therapy. Cancers, 2020, 12(8), 2064. doi: 10.3390/cancers12082064 PMID: 32726914</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Seltzer, E.S.; Watters, A.K.; MacKenzie, D., Jr; Granat, L.M.; Zhang, D. Cannabidiol (CBD) as a promising anti-cancer drug. Cancers, 2020, 12(11), 3203. doi: 10.3390/cancers12113203 PMID: 33143283</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Han, C.C.; Wang, Y. Anti-inflammation effects of Sophora flavescens nanoparticles. Inflammation, 2012, 35(4), 1262-1268. doi: 10.1007/s10753-012-9437-6 PMID: 22327863</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Sivakumar, S.; Subban, M.; Chinnasamy, R.; Chinnaperumal, K.; Nakouti, I.; El-Sheikh, M.A.; Shaik, J.P. Green synthesized silver nanoparticles using Andrographis macrobotrys Nees leaf extract and its potential to antibacterial, antioxidant, anti-inflammatory and lung cancer cells cytotoxicity effects. Inorg. Chem. Commun., 2023, 153, 110787. doi: 10.1016/j.inoche.2023.110787</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Siddique, S.; Chow, J.C.L. Gold nanoparticles for drug delivery and cancer therapy. Appl. Sci., 2020, 10(11), 3824. doi: 10.3390/app10113824</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Shen, Z.; Wu, A.; Chen, X. Iron oxide nanoparticle based contrast agents for magnetic resonance imaging. Mol. Pharm., 2017, 14(5), 1352-1364. doi: 10.1021/acs.molpharmaceut.6b00839 PMID: 27776215</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Tyagi, P.K.; Arya, A.; Mazumder, A.M.; Tyagi, S. Development of copper nanoparticles and their prospective uses as antioxidants, antimicrobials, anticancer agents in the pharmaceutical sector. Precis. Nanomed., 2023, 6(2), 1048-1065. doi: 10.33218/001c.83932</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Anjum, S.; Hashim, M.; Malik, S.A.; Khan, M.; Lorenzo, J.M.; Abbasi, B.H.; Hano, C. Recent advances in zinc oxide nanoparticles (ZnO NPs) for cancer diagnosis, target drug delivery, and treatment. Cancers, 2021, 13(18), 4570. doi: 10.3390/cancers13184570 PMID: 34572797</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Tinajero-Díaz, E.; Salado-Leza, D.; Gonzalez, C.; Martínez Velázquez, M.; López, Z.; Bravo-Madrigal, J.; Knauth, P.; Flores-Hernández, F.Y.; Herrera-Rodríguez, S.E.; Navarro, R.E.; Cabrera-Wrooman, A.; Krötzsch, E.; Carvajal, Z.Y.G.; Hernández-Gutiérrez, R. Green metallic nanoparticles for cancer therapy: Evaluation models and cancer applications. Pharmaceutics, 2021, 13(10), 1719. doi: 10.3390/pharmaceutics13101719 PMID: 34684012</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Păduraru, D.N.; Ion, D.; Niculescu, A.G.; Mușat, F.; Andronic, O.; Grumezescu, A.M.; Bolocan, A. Recent developments in metallic nanomaterials for cancer therapy, diagnosing and imaging applications. Pharmaceutics, 2022, 14(2), 435. doi: 10.3390/pharmaceutics14020435 PMID: 35214167</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Huang, Y.; Xiao, D.; Burton-Freeman, B.M.; Edirisinghe, I. Chemical changes of bioactive phytochemicals during thermal processing. Shipin Kexue, 2016, 1-9. doi: 10.1016/B978-0-08-100596-5.03055-9</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Ahmad, F.; Ashraf, N.; Ashraf, T.; Zhou, R.B.; Yin, D.C. Biological synthesis of metallic nanoparticles (MNPs) by plants and microbes: Their cellular uptake, biocompatibility, and biomedical applications. Appl. Microbiol. Biotechnol., 2019, 103(7), 2913-2935. doi: 10.1007/s00253-019-09675-5 PMID: 30778643</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Ullah Khan, S.; Saleh, T.A.; Wahab, A.; Ullah Khan, M.H.; Khan, D.; Ullah Khan, W.; Rahim, A.; Kamal, S.; Ullah Khan, F.; Fahad, S. Nanosilver: New ageless and versatile biomedical therapeutic scaffold. Int. J. Nanomed., 2018, 13, 733-762. doi: 10.2147/IJN.S153167 PMID: 29440898</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Patra, J.K.; Das, G.; Fraceto, L.F.; Campos, E.V.R.; Rodriguez-Torres, M.P.; Acosta-Torres, L.S.; Diaz-Torres, L.A.; Grillo, R.; Swamy, M.K.; Sharma, S.; Habtemariam, S.; Shin, H.S. Nano based drug delivery systems: Recent developments and future prospects. J. Nanobiotechnol., 2018, 16(1), 71. doi: 10.1186/s12951-018-0392-8 PMID: 30231877</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Jeyaraj, M.; Arun, R.; Sathishkumar, G. MubarakAli, D.; Rajesh, M.; Sivanandhan, G.; Kapildev, G.; Manickavasagam, M.; Thajuddin, N.; Ganapathi, A. An evidence on G2/M arrest, DNA damage and caspase mediated apoptotic effect of biosynthesized gold nanoparticles on human cervical carcinoma cells (HeLa). Mater. Res. Bull., 2014, 52, 15-24. doi: 10.1016/j.materresbull.2013.12.060</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>Ratan, Z.A.; Haidere, M.F.; Nurunnabi, M.; Shahriar, S.M.; Ahammad, A.J.S.; Shim, Y.Y.; Reaney, M.J.T.; Cho, J.Y. Green chemistry synthesis of silver nanoparticles and their potential anticancer effects. Cancers, 2020, 12(4), 855. doi: 10.3390/cancers12040855 PMID: 32244822</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>Dey, A.; Yogamoorthy, A.; Sundarapandian, S.M. Green synthesis of gold nanoparticles and evaluation of its cytotoxic property against colon cancer cell line. Res. J. Life Sci. Bioinform. Pharm. Chem. Sci., 2018, 4, 1-17.</mixed-citation></ref><ref id="B59"><label>59.</label><mixed-citation>Cheeseman, S.; Christofferson, A.J.; Kariuki, R.; Cozzolino, D.; Daeneke, T.; Crawford, R.J.; Truong, V.K.; Chapman, J.; Elbourne, A. Antimicrobial metal nanomaterials: From passive to stimuli‐activated applications. Adv. Sci., 2020, 7(10), 1902913. doi: 10.1002/advs.201902913 PMID: 32440470</mixed-citation></ref><ref id="B60"><label>60.</label><mixed-citation>Sanità, G.; Carrese, B.; Lamberti, A. Nanoparticle surface functionalization: How to improve biocompatibility and cellular internalization. Front. Mol. Biosci., 2020, 7, 587012. doi: 10.3389/fmolb.2020.587012 PMID: 33324678</mixed-citation></ref><ref id="B61"><label>61.</label><mixed-citation>Ke, Y.; Al Aboody, M.S.; Alturaiki, W.; Alsagaby, S.A.; Alfaiz, F.A.; Veeraraghavan, V.P.; Mickymaray, S. Photosynthesized gold nanoparticles from Catharanthus roseus induces caspase-mediated apoptosis in cervical cancer cells (HeLa). Artif. Cells Nanomed. Biotechnol., 2019, 47(1), 1938-1946. doi: 10.1080/21691401.2019.1614017 PMID: 31099261</mixed-citation></ref><ref id="B62"><label>62.</label><mixed-citation>Jiang, J.; Pi, J.; Cai, J. The advancing of zinc oxide nanoparticles for biomedical applications. Bioinorg. Chem. Appl., 2018, 2018, 1-18. doi: 10.1155/2018/1062562 PMID: 30073019</mixed-citation></ref><ref id="B63"><label>63.</label><mixed-citation>Khandel, P.; Yadaw, R.K.; Soni, D.K.; Kanwar, L.; Shahi, S.K. Biogenesis of metal nanoparticles and their pharmacological applications: present status and application prospects. J. Nanostructure Chem., 2018, 8(3), 217-254. doi: 10.1007/s40097-018-0267-4</mixed-citation></ref><ref id="B64"><label>64.</label><mixed-citation>Selim, Y.A. Green synthesis of zinc oxide nanoparticles using aqueous extract of Deverratortuosa and their cytotoxic activities. Sci. Rep., 2020, 10(1), 3445. doi: 10.1038/s41598-020-60541-1 PMID: 32103090</mixed-citation></ref><ref id="B65"><label>65.</label><mixed-citation>Siddiqi, K.S.; Husen, A. Current status of plant metabolite-based fabrication of copper/copper oxide nanoparticles and their applications: A review. Biomater. Res., 2020, 24(1), 11. doi: 10.1186/s40824-020-00188-1 PMID: 32514371</mixed-citation></ref><ref id="B66"><label>66.</label><mixed-citation>Cuong, H.N.; Pansambal, S.; Ghotekar, S.; Oza, R.; Thanh Hai, N.T.; Viet, N.M.; Nguyen, V.H. New frontiers in the plant extract mediated biosynthesis of copper oxide (CuO) nanoparticles and their potential applications: A review. Environ. Res., 2022, 203, 111858. doi: 10.1016/j.envres.2021.111858 PMID: 34389352</mixed-citation></ref><ref id="B67"><label>67.</label><mixed-citation>Ying, S.; Guan, Z.; Ofoegbu, P.C.; Clubb, P.; Rico, C.; He, F.; Hong, J. Green synthesis of nanoparticles: Current developments and limitations. Environ. Technol. Innovation, 2022, 26, 102336. doi: 10.1016/j.eti.2022.102336</mixed-citation></ref><ref id="B68"><label>68.</label><mixed-citation>Chandra, H.; Kumari, P.; Bontempi, E.; Yadav, S. Medicinal plants: Treasure trove for green synthesis of metallic nanoparticles and their biomedical applications. Biocatal. Agric. Biotechnol., 2020, 24, 101518. doi: 10.1016/j.bcab.2020.101518</mixed-citation></ref><ref id="B69"><label>69.</label><mixed-citation>Jain, S.; Saxena, N.; Sharma, M.K.; Chatterjee, S. Metal nanoparticles and medicinal plants: Present status and future prospects in cancer therapy. Mater. Today Proc., 2020, 31, 662-673. doi: 10.1016/j.matpr.2020.06.602</mixed-citation></ref><ref id="B70"><label>70.</label><mixed-citation>S M. S.; Naveen, N.R.; Rao, G.K.; Gopan, G.; Chopra, H.; Park, M.N.; Alshahrani, M.M.; Jose, J.; Emran, T.B.; Kim, B. A spotlight on alkaloid nanoformulations for the treatment of lung cancer. Front. Oncol., 2022, 12, 994155. doi: 10.3389/fonc.2022.994155 PMID: 36330493</mixed-citation></ref><ref id="B71"><label>71.</label><mixed-citation>Shang, Y.; Hasan, M.K.; Ahammed, G.J.; Li, M.; Yin, H.; Zhou, J. Applications of nanotechnology in plant growth and crop protection: A review. Molecules, 2019, 24(14), 2558-2580. doi: 10.3390/molecules24142558 PMID: 31337070</mixed-citation></ref><ref id="B72"><label>72.</label><mixed-citation>Ramezani Farani, M.; Azarian, M.; Heydari Sheikh Hossein, H.; Abdolvahabi, Z.; Mohammadi Abgarmi, Z.; Moradi, A.; Mousavi, S.M.; Ashrafizadeh, M.; Makvandi, P.; Saeb, M.R.; Rabiee, N. Folic acid-adorned curcumin-loaded iron oxide nanoparticles for cervical cancer. ACS Appl. Bio Mater., 2022, 5(3), 1305-1318. doi: 10.1021/acsabm.1c01311 PMID: 35201760</mixed-citation></ref><ref id="B73"><label>73.</label><mixed-citation>Zhao, Z.; Anselmo, A.C.; Mitragotri, S. Viral vector‐based gene therapies in the clinic. Bioeng. Transl. Med., 2022, 7(1), e10258. doi: 10.1002/btm2.10258 PMID: 35079633</mixed-citation></ref><ref id="B74"><label>74.</label><mixed-citation>Santiago-Ortiz, J.L.; Schaffer, D.V. Adeno-associated virus (AAV) vectors in cancer gene therapy. J. Control. Release, 2016, 240, 287-301. doi: 10.1016/j.jconrel.2016.01.001 PMID: 26796040</mixed-citation></ref><ref id="B75"><label>75.</label><mixed-citation>Kaiser, J. How safe is a popular gene therapy vector? Science, 2020, 367(6474), 131. doi: 10.1126/science.367.6474.131 PMID: 31919200</mixed-citation></ref><ref id="B76"><label>76.</label><mixed-citation>Kaeppel, C.; Beattie, S.G.; Fronza, R.; van Logtenstein, R.; Salmon, F.; Schmidt, S.; Wolf, S.; Nowrouzi, A.; Glimm, H.; von Kalle, C.; Petry, H.; Gaudet, D.; Schmidt, M. A largely random AAV integration profile after LPLD gene therapy. Nat. Med., 2013, 19(7), 889-891. doi: 10.1038/nm.3230 PMID: 23770691</mixed-citation></ref><ref id="B77"><label>77.</label><mixed-citation>Chowdhury, E.A.; Meno-Tetang, G.; Chang, H.Y.; Wu, S.; Huang, H.W.; Jamier, T.; Chandran, J.; Shah, D.K. Current progress and limitations of AAV mediated delivery of protein therapeutic genes and the importance of developing quantitative pharmacokinetic/pharmacodynamic (PK/PD) models. Adv. Drug Deliv. Rev., 2021, 170, 214-237. doi: 10.1016/j.addr.2021.01.017 PMID: 33486008</mixed-citation></ref><ref id="B78"><label>78.</label><mixed-citation>Stanicki, D.; Vangijzegem, T.; Ternad, I.; Laurent, S. An update on the applications and characteristics of magnetic iron oxide nanoparticles for drug delivery. Expert Opin. Drug Deliv., 2022, 19(3), 321-335. doi: 10.1080/17425247.2022.2047020 PMID: 35202551</mixed-citation></ref><ref id="B79"><label>79.</label><mixed-citation>Luther, D.C.; Huang, R.; Jeon, T.; Zhang, X.; Lee, Y.W.; Nagaraj, H.; Rotello, V.M. Delivery of drugs, proteins, and nucleic acids using inorganic nanoparticles. Adv. Drug Deliv. Rev., 2020, 156, 188-213. doi: 10.1016/j.addr.2020.06.020 PMID: 32610061</mixed-citation></ref><ref id="B80"><label>80.</label><mixed-citation>Tong, S.; Zhu, H.; Bao, G. Magnetic iron oxide nanoparticles for disease detection and therapy. Mater. Today, 2019, 31, 86-99. doi: 10.1016/j.mattod.2019.06.003 PMID: 32831620</mixed-citation></ref><ref id="B81"><label>81.</label><mixed-citation>Hola, K.; Markova, Z.; Zoppellaro, G.; Tucek, J.; Zboril, R. Tailored functionalization of iron oxide nanoparticles for MRI, drug delivery, magnetic separation and immobilization of biosubstances. Biotechnol. Adv., 2015, 33(6), 1162-1176. doi: 10.1016/j.biotechadv.2015.02.003 PMID: 25689073</mixed-citation></ref><ref id="B82"><label>82.</label><mixed-citation>Luo, X.; Zhao, W.; Li, B.; Zhang, X.; Zhang, C.; Bratasz, A.; Deng, B.; McComb, D.W.; Dong, Y. Co-delivery of mRNA and SPIONs through amino-ester nanomaterials. Nano Res., 2018, 11(10), 5596-5603. doi: 10.1007/s12274-018-2082-0 PMID: 31737222</mixed-citation></ref><ref id="B83"><label>83.</label><mixed-citation>Zhang, Y.; Fu, X.; Jia, J.; Wikerholmen, T.; Xi, K.; Kong, Y.; Wang, J.; Chen, H.; Ma, Y.; Li, Z.; Wang, C.; Qi, Q.; Thorsen, F.; Wang, J.; Cui, J.; Li, X.; Ni, S. Glioblastoma therapy using codelivery of cisplatin and glutathione peroxidase targeting siRNA from iron oxide nanoparticles. ACS Appl. Mater. Interfaces, 2020, 12(39), 43408-43421. doi: 10.1021/acsami.0c12042 PMID: 32885649</mixed-citation></ref><ref id="B84"><label>84.</label><mixed-citation>Yang, Z.; Duan, J.; Wang, J.; Liu, Q.; Shang, R.; Yang, X.; Lu, P.; Xia, C.; Wang, L.; Dou, K. Superparamagnetic iron oxide nanoparticles modified with polyethylenimine and galactose for siRNA targeted delivery in hepatocellular carcinoma therapy. Int. J. Nanomedicine, 2018, 13, 1851-1865. doi: 10.2147/IJN.S155537 PMID: 29618926</mixed-citation></ref><ref id="B85"><label>85.</label><mixed-citation>Revia, R.A.; Stephen, Z.R.; Zhang, M. Theranostic nanoparticles for RNA-Based cancer treatment. Acc. Chem. Res., 2019, 52(6), 1496-1506. doi: 10.1021/acs.accounts.9b00101 PMID: 31135134</mixed-citation></ref><ref id="B86"><label>86.</label><mixed-citation>Song, Y.; Li, D.; Lu, Y.; Jiang, K.; Yang, Y.; Xu, Y.; Dong, L.; Yan, X.; Ling, D.; Yang, X.; Yu, S.H. Ferrimagnetic mPEG- b -PHEP copolymer micelles loaded with iron oxide nanocubes and emodin for enhanced magnetic hyperthermiachemotherapy. Natl. Sci. Rev., 2020, 7(4), 723-736. doi: 10.1093/nsr/nwz201 PMID: 34692091</mixed-citation></ref><ref id="B87"><label>87.</label><mixed-citation>Ulbrich, K.; Holá, K.; ubr, V.; Bakandritsos, A.; Tuček, J.; Zbořil, R. Targeted drug delivery with polymers and magnetic nanoparticles: Covalent and noncovalent approaches, release control, and clinical studies. Chem. Rev., 2016, 116(9), 5338-5431. doi: 10.1021/acs.chemrev.5b00589 PMID: 27109701</mixed-citation></ref><ref id="B88"><label>88.</label><mixed-citation>Lee, G.Y.; Qian, W.P.; Wang, L.; Wang, Y.A.; Staley, C.A.; Satpathy, M.; Nie, S.; Mao, H.; Yang, L. Theranostic nanoparticles with controlled release of gemcitabine for targeted therapy and MRI of pancreatic cancer. ACS Nano, 2013, 7(3), 2078-2089. doi: 10.1021/nn3043463 PMID: 23402593</mixed-citation></ref><ref id="B89"><label>89.</label><mixed-citation>Lee, N.; Yoo, D.; Ling, D.; Cho, M.H.; Hyeon, T.; Cheon, J. Iron oxide-based nanoparticles for multimodal imaging and magnetoresponsive therapy. Chem. Rev., 2015, 115(19), 10637-10689. doi: 10.1021/acs.chemrev.5b00112 PMID: 26250431</mixed-citation></ref><ref id="B90"><label>90.</label><mixed-citation>Gavilán, H.; Avugadda, S.K.; Fernández-Cabada, T.; Soni, N.; Cassani, M.; Mai, B.T.; Chantrell, R.; Pellegrino, T. Magnetic nanoparticles and clusters for magnetic hyperthermia: Optimizing their heat performance and developing combinatorial therapies to tackle cancer. Chem. Soc. Rev., 2021, 50(20), 11614-11667. doi: 10.1039/D1CS00427A PMID: 34661212</mixed-citation></ref><ref id="B91"><label>91.</label><mixed-citation>Li, Y.; Chen, W.; Qi, Y.; Wang, S.; Li, L.; Li, W.; Xie, T.; Zhu, H.; Tang, Z.; Zhou, M. H2S-Scavenged and activated iron oxide−hydroxide nanospindles for MRI−guided photothermal therapy and ferroptosis in colon cancer. Small, 2020, 16(37), 2001356. doi: 10.1002/smll.202001356 PMID: 32789963</mixed-citation></ref><ref id="B92"><label>92.</label><mixed-citation>Laurent, S.; Saei, A.A.; Behzadi, S.; Panahifar, A.; Mahmoudi, M. Superparamagnetic iron oxide nanoparticles for delivery of therapeutic agents: Opportunities and challenges. Expert Opin. Drug Deliv., 2014, 11(9), 1449-1470. doi: 10.1517/17425247.2014.924501 PMID: 24870351</mixed-citation></ref><ref id="B93"><label>93.</label><mixed-citation>Vázquez-Núñez, E.; Molina-Guerrero, C.E.; Peña-Castro, J.M.; Fernández-Luqueño, F.; de la Rosa-Álvarez, M.G. Use of nanotechnology for the bioremediation of contaminants: A review. Processes, 2020, 8(7), 826. doi: 10.3390/pr8070826</mixed-citation></ref><ref id="B94"><label>94.</label><mixed-citation>Smith, R.A.; Andrews, K.S.; Brooks, D.; Fedewa, S.A.; Manassaram-Baptiste, D.; Saslow, D.; Wender, R.C. Cancer screening in the United States, 2019: A review of current American Cancer Society guidelines and current issues in cancer screening. CA Cancer J. Clin., 2019, 69(3), 184-210. doi: 10.3322/caac.21557 PMID: 30875085</mixed-citation></ref><ref id="B95"><label>95.</label><mixed-citation>Benelmekki, M. An introduction to nanoparticles and nanotechnology. In: Designing hybrid nanoparticles; Morgan &amp; Claypool Publishers, 2015. doi: 10.1088/978-1-6270-5469-0ch1</mixed-citation></ref><ref id="B96"><label>96.</label><mixed-citation>Shipunova, V.O.; Belova, M.M.; Kotelnikova, P.A.; Shilova, O.N.; Mirkasymov, A.B.; Danilova, N.V.; Komedchikova, E.N.; Popovtzer, R.; Deyev, S.M.; Nikitin, M.P. Photothermal therapy with HER2-targeted silver nanoparticles leading to cancer remission. Pharmaceutics, 2022, 14(5), 1013. doi: 10.3390/pharmaceutics14051013 PMID: 35631598</mixed-citation></ref><ref id="B97"><label>97.</label><mixed-citation>Chaudhary, V. Sonu; Chowdhury, R.; Thukral, P.; Pathania, D.; Saklani, S.; Lucky; Rustagi, S.; Gautam, A.; Mishra, Y.K.; Singh, P.; Kaushik, A. Biogenic green metal nano systems as efficient anti-cancer agents. Environ. Res., 2023, 229, 115933. doi: 10.1016/j.envres.2023.115933 PMID: 37080272</mixed-citation></ref><ref id="B98"><label>98.</label><mixed-citation>Li, X.; Chen, L.; Luan, S.; Zhou, J.; Xiao, X.; Yang, Y.; Mao, C.; Fang, P.; Chen, L.; Zeng, X.; Gao, H. The development and progress of nanomedicine for oesophagal cancer diagnosis and treatment. In: Seminars in cancer biology; Academic Press, 2022; Vol. 86, pp. 873-885.</mixed-citation></ref><ref id="B99"><label>99.</label><mixed-citation>Muhamad, M.; Ab Rahim, N.; Wan Omar, W.A.; Nik Mohamed Kamal, N.N.S. Cytotoxicity, and genotoxicity of biogenic silver nanoparticles in A549 and BEAS-2B cell lines. Bioinorg. Chem. Appl., 2022, 2022, 8546079. doi: 10.1155/2022/8546079 PMID: 36193250</mixed-citation></ref><ref id="B100"><label>100.</label><mixed-citation>Kumar, H.; Bhardwaj, K.; Nepovimova, E.; Kuča, K.; Singh Dhanjal, D.; Bhardwaj, S.; Bhatia, S.K.; Verma, R.; Kumar, D. Antioxidant functionalized nanoparticles: A combat against oxidative stress. Nanomaterials, 2020, 10(7), 1334. doi: 10.3390/nano10071334 PMID: 32650608</mixed-citation></ref><ref id="B101"><label>101.</label><mixed-citation>Baranwal, A.; Mahato, K.; Srivastava, A.; Maurya, P.K.; Chandra, P. Phytofabricated metallic nanoparticles and their clinical applications. RSC Advances, 2016, 6(107), 105996-106010. doi: 10.1039/C6RA23411A</mixed-citation></ref><ref id="B102"><label>102.</label><mixed-citation>Rasool, M.; Malik, A.; Waquar, S.; Arooj, M.; Zahid, S.; Asif, M.; Shaheen, S.; Hussain, A.; Ullah, H.; Gan, S.H. New challenges in the use of nanomedicine in cancer therapy. Bioengineered, 2022, 13(1), 759-773. doi: 10.1080/21655979.2021.2012907 PMID: 34856849</mixed-citation></ref><ref id="B103"><label>103.</label><mixed-citation>Shamaila, S.; Sajjad, A.K.L.; Ryma, N-A.; Farooqi, S.A.; Jabeen, N.; Majeed, S.; Farooq, I. Advancements in nanoparticle fabrication by hazard free eco-friendly green routes. Appl. Mater. Today, 2016, 5, 150-199. doi: 10.1016/j.apmt.2016.09.009</mixed-citation></ref></ref-list></back></article>
