Anti-Inflammatory & Anti-Allergy Agents in Medicinal ChemistryAnti-Inflammatory & Anti-Allergy Agents in Medicinal ChemistryAnti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry1871-52301875-614XBentham Science64463410.2174/0118715230275741231207115011MedicineResearch ArticlePyrazoles as Anti-inflammatory and Analgesic Agents: In-vivo and In-silico StudiesChahalGeetainfo@benthamscience.netMongaJyotiinfo@benthamscience.netRaniIshainfo@benthamscience.netSainiShubhaminfo@benthamscience.netDevgunManishinfo@benthamscience.netHusainAsifinfo@benthamscience.netLal KhokraSukhbirinfo@benthamscience.netInstitute of Pharmaceutical Sciences, Kurukshetra University, Ch. Devi Lal College of Pharmacy, Spurthy College of PharmacyDepartment of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research,, Jamia Hamdard01012024231395107012025Copyright ©; 2024, Bentham Science Publishers2024Bentham Science Publishershttps://journals.eco-vector.com/1871-5230/article/view/644634

Background::Pyrazole is a well-known nucleus in the pharmacy field with a wide range of other activities in addition to anti-inflammatory and analgesic, i.e., anticonvulsant, antiviral, and anticancer activities. There are well-known marketed drugs having pyrazole moi-ety as celecoxib, and lonazolac as COX-II inhibitors.

Aims::We aim to synthesize better anti-inflammatory than existing ones. Thiophene is also known for its analgesic and anti-inflammatory action. Thus, the fusion of both gives better anti-inflammatory agents. In the present studies, derivatives from two series of pyrazole were prepared by reacting substituted chalcone (3a-3f) derivatives prepared from 2-acetyl thiophene. They substituted aromatic aldehydes with phenyl hydrazine to form (5a-5f) and with 2, 4-dinitro phenyl hydrazine giving compounds (6a-6f) separately.

Methods::Purified and characterized pyrazoles have been analyzed for in-vivo analgesic and anti-inflammatory activities by using standard methods. Compounds 5e, 5f, and 6d were proved to be potent analgesics and series (5a-5f) was found to have anti-inflammatory action, which was further validated using docking and ADME studies.

Results::The ADME profile of synthesized compounds was found to be satisfactory.

Conclusion::The synthesized compounds can serve as lead for further drug designing.

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