Anti-Inflammatory & Anti-Allergy Agents in Medicinal ChemistryAnti-Inflammatory & Anti-Allergy Agents in Medicinal ChemistryAnti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry1871-52301875-614XBentham Science64465010.2174/0118715230282982240202052127MedicineResearch ArticleAnalgesic and Anti-inflammatory Potential of the New Tetrahydropyran Derivative (2s,6s)-6-ethyl-tetrahydro-2h-pyran-2-yl) MethanolCastroGustavoinfo@benthamscience.netde SouzaRaquelinfo@benthamscience.netda SilvaAlbainfo@benthamscience.netLaureano-MeloRobertoinfo@benthamscience.netda Silva CôrtesWellingtoninfo@benthamscience.netCapimSauloinfo@benthamscience.netde Almeida VasconcellosMárioinfo@benthamscience.netMarinhoBrunoinfo@benthamscience.netLaboratório de Farmacologia da Inflamação e Nocicepção, Programa de Pós-Graduação em Medicina Veterinária, Instituto de Veterinária, Universidade Federal Rural do Rio de JaneiroLaboratório de Cultura de Células, Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de JaneiroLaboratório de Fisiofarmacologia Comportamental, Centro Universitário de Barra MansaLaboratório de Psicofarmacologia e Comportamento, Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas, Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de JaneiroInstituto Federal de Educação, Ciência e Tecnologia Baiano, Federal Institute BaianoLaboratório de Síntese Orgânica Medicinal da Paraíba (LASOM-PB), Departamento de Química, Universidade Federal da Paraíba0102202423210511707012025Copyright ©; 2024, Bentham Science Publishers2024Bentham Science Publishershttps://journals.eco-vector.com/1871-5230/article/view/644650

Background:The development of analgesic and anti-inflammatory drugs plays a crucial role in modern medicine, aiming to alleviate pain and reduce inflammation in patients. Opioids and nonsteroidal anti-inflammatory drugs are groups of drugs conventionally used to treat pain and in-flammation, but a wide range of adverse effects and ineffectiveness in some pathological conditions leads us to search for new drugs with analgesic and anti-inflammatory properties.

Objectives:In this regard, the authors intend to investigate the ((2s,6s)-6-ethyl-tetrahydro-2h-pyran-2-yl) methanol compound (LS20) on pain and acute inflammation.

Methods:Male Swiss mice were evaluated using acetic acid-induced abdominal writhing, formalin, and tail-flick as models of nociceptive evaluation and edema paw, air pouch and cell culture as models of inflammatory evaluation besides the rotarod test for assessment of motor impairment.

Results:The compound showed an effect on the acetic acid-induced abdominal writhing, formalin and tail-flick tests. Studying the mechanism of action, reversion of the antinociceptive effect of the compound was observed from previous intraperitoneal administration of selective and non-selective opioid antagonists on the tail flick test. In addition, the compound induced an antiedematogenic effect and reduced leukocyte migration and the production of pro-inflammatory cytokines in the air pouch model. LS20 was able to maintain cell viability, in addition to reducing cell production of TNF-α and IL-6.

Conclusion:In summary, the LS20 compound presented an antinociceptive effect, demonstrating the participation of the opioid system and an anti-inflammatory effect related to the inhibition of pro-inflammatory cytokine production. The compound also demonstrated safety at the cellular level.

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