Anti-Inflammatory & Anti-Allergy Agents in Medicinal ChemistryAnti-Inflammatory & Anti-Allergy Agents in Medicinal ChemistryAnti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry1871-52301875-614XBentham Science64465710.2174/0118715230276597240207070306MedicineResearch ArticleDevelopment and Evaluation of Celecoxib Emulgel by Using Natural OilRajputAartiinfo@benthamscience.netGaurRishabhinfo@benthamscience.netKulshreshthaMayankinfo@benthamscience.netJadaunSumedhainfo@benthamscience.netKumariVibhainfo@benthamscience.netDepartment of Pharmaceutics, Rajiv Academy for PharmacyDepartment of Pharmacology, Rajiv Academy for Pharmacy0102202423212913707012025Copyright ©; 2024, Bentham Science Publishers2024Bentham Science Publishershttps://journals.eco-vector.com/1871-5230/article/view/644657

Background:Emulgel combines the qualities of an emulsion with those of a gel. In order to create an emulgel w/o or o/w, emulsions have to be formulated, which are then com-bined with a gelling agent, resulting in a dual-control drug release. Celecoxib exhibits analge-sic, antipyretic and anti-inflammatory activities and is used to treat osteoarthritis, severe pain, rheumatoid arthritis, and other medical conditions.

Methods:Celecoxib Emulgel was developed and evaluated by using natural oil and carbopol-940 as a gelling agent in different concentrations. The screening of various oils, co-surfactants and surfactants was performed to determine the solubility. The essential oils (eucalyptus oil and turpentine oil) were used as penetration modifiers. Studies on compatibility with polymers have been conducted, and the results indicate that there should be no physical or chemical interactions between the polymers and the drug substance. For the preparation of emulgel, various emulsions were prepared with Smix (cosurfactant and surfactant) ratios (1:1, 2:1 and 3:1). The selection of a gelling agent was done by incorporating the selected emulsion system ratio of 1:1 with the combinations of polymers carbapol 940, carbapol 934, and HPMC (0:1:0, 0:0.5:1, 0:0:3, 0.5:0:1, 1:0:0) gel base to make a homogenous emulgel.

Results:The emulgel was examined visually to see if it had any phase behaviour, feel, spread-ability, and grittiness by applying its thin layer to a slide. Then, all six formulations of emulgel were prepared with the selected gelling agent. All emulgels were evaluated for pH, physical properties (consistency, homogeneity, colour, texture), drug content, spreadability, extrudabil-ity, swelling index, viscosity, stability and centrifugation. A Franz diffusion cell and an egg membrane were used to perform in-vitro drug release.

Conclusion:Among all prepared formulations, EG1 had a better release, higher viscosity, higher drug content, and a higher swelling index than the others. The formulation EG1 showed higher drug release (91.25%) within 8 hours.

Celecoxibpenetration modifieressential oilsgelling agentNSAIDsemulsion.Arora, R.; Khan, R.; Ojha, A.; Chopra, H.; Upadhyaya, K. Formulation and Evaluation of Terbinafine emulgel for superficial fungal infection. Res. J. Pharma. Technol., 2018, 11(11), 5029-5036. doi: 10.5958/0974-360X.2018.00917.4Shaik, N.B.; Gera, S.; Kukati, L.; Goverdhanam, H. Formulation and evaluation of emulgel of Flurbiprofen. Int. Res. J. Pharma., 2019, 10(8), 68-76. doi: 10.7897/2230-8407.1008248Meghna, K.S. Formulation and evaluation of celecoxib emulgel for topical delivery. Asian J. Biochem. Pharmaceut. Res., 2017, 10(4), 54-59.Sreevidya, V.S. An overview on emulgel. Int. J. Pharmaceut. Phtopharmacol. Res., 2019, 9(1), 92-97.Ubaid, M.; Ilyas, S.; Mir, S.; Khan, A.K.; Rashid, R.; Khan, M.Z.U. Formulation and in vitro evaluation of Carbopol 934 based modified Clotrimazole gel for topical application. Annal. Brazil. Acad. Sci., 2016, 88(4), 2303-2317.Khan, B.A.; Akhtar, N.; Shoiab Khan, H.M.; Waseem, K.; Mahmood, T.; Rasul, A. Basics of Pharmaceutical emulsions: A Review. Afr. J. Pharm. Pharmacol., 2011, 525(25), 2715-2725.Upadhyaya, S.; Chauhan Bisth, S.; Kothiyal, P. Emulgel: A boon for dermatological diseases. Int. J. Pharmaceut. Res. All. Sci., 2014, 3(4), 1-9.Sriaandhal Sabalingam, ; Siriwardhene, M.A. A review on emerging applications of emulgel as topical drug delivery system. World J. Adv. Res. Rev., 2022, 13(1), 452-463. doi: 10.30574/wjarr.2022.13.1.0048Magdy, I. Optimization of chlorphenesin emulgel formulation. Am. Assoc. Pharmaceut. Scient. J., 2004, 6(3), 81-87.Karade, P.; Shah, R.R.; Chougule, D.D.; Bhise, S.B. Formulation and evaluation of celecoxib gel. J. Drug Deliv. Ther., 2012, 2(3), 32-135. doi: 10.22270/jddt.v2i3.148Kumar, P.; Chaudhary, M.; Bhattacharya, S.; Juyal, V. Validated analytical method development of celecoxib in bulk, tablet and rat plasma by UV-spectroscopy. Res. J. Pharma. Technol., 2010, 3(3), 894-896.Jain, A.; Deveda, P.; Vyas, N. Development of antifungal emulsion based gel for topical fungal infection(S). Int. J. Pharma. Res. Developm., 2011, 2(12), 315-346.Sunitha Reddy, M.; Tanzeem, S.K. Formulation and evaluation of celecoxib emulgel. Int. J. Pharm. Biol. Sci., 2020, 10(1), 80-92.Yassin, G. Formulation and evaluation of optimized clotrimazole emulgel formulations. Br. J. Pharm. Res., 2014, 4(9), 1014-1030. doi: 10.9734/BJPR/2014/8495Shivappa, N.; Arjun, M.; Rohini, B.; Ganesh, N. Design, development and evaluation of microemulgel containing econazole nitrate. Int. J. Curr. Res., 2018, 10(8), 72727-72733.Yadav, S.K.; Mishra, M.K.; Tiwari, A.; Shukla, A. Emulgel: A new approach for enhanced topical drug delivery. Int. J. Curr. Pharm. Res., 2016, 9(1), 15-19. doi: 10.22159/ijcpr.2017v9i1.16628Rao, S.; Barot, T.; Rajesh, K.S.; Jha, L.L. Formulation, optimization and evaluation of microemulsion based gel of Butenafine Hydrochloride for topical delivery by using simplex lattice mixture design. J. Pharm. Investig., 2016, 46(1), 1-12. doi: 10.1007/s40005-015-0207-ySojana, N.; Mounika, N.; Priyanka, G.; Venkatesh, A. Design and optimization of clotrimazole emulgel by using various polymers. World J. Adv. Res. Rev., 2020, 7(2), 188-199. doi: 10.30574/wjarr.2020.7.2.0281Bhattacharya, S.; Prajapati, B.G. Formulation and optimization of celecoxib nano emulgel. Asian J. Pharm. Clin. Res., 2017, 10(8), 353-365. doi: 10.22159/ajpcr.2017.v10i8.19510Sah, S.K.; Badola, A.; Nayak, B.K. Emulgel: Magnifying the application of topical drug delivery. Indian J. Pharmaceut. Biol. Res., 2017, 5(1), 25-33. doi: 10.30750/ijpbr.5.1.4Aggarwal, S.; Aggarwal, S.; Jalhan, S. Essential oils as novel human skin penetration enhancer for transdermal drug delivery. Int. J. Pharm. Biol. Sci., 2013, 4(1), 857-868.Charyulu, N.R.; Joshi, P.; Dubey, A.; Shetty, A. Emulgel: A boon for enhanced topical drug delivery. J. Young Pharm., 2021, 13(1), 76-79. doi: 10.5530/jyp.2021.13.17Patel, S.; Aundhia, C.; Seth, A.; Shah, N.; Pandya, K. A novel approach for topical drug delivery. Europ. J. Biomed. Pharmaceut. Sci., 2016, 3(9), 501-506.Fatehalrahman, F.M.; Elamin, I.E.; Shayoub, M.E.; Elnazeer, I.H. Compatibility assessment of Quercus infectoria galls (Fagaceae) ethanolic extract with Carbopol940 and xanthan gum polymers as preformulation-study. World J. Pharm. Res., 2018, 7(17), 44-57.Joshi, B.; Singh, G.; Rana, A.; Saini, S. Development and characterization of clarithromycin emulgel for topical delivery. Int. J. Drug Develop. Res., 2012, 4(3), 310-313.Maskare, R.; Thakre, S.; Gupta, V.; Basantwani, M.; Kshirsagar, A.; Bahekar, T. Formulation and evaluation of Emulgel for topical delivery of Dexibuprofen, Research. J. Pharm. Technol., 2022, 15(2), 745-750.Shahin, M.; Abdel Hady, S.; Hammad, M.; Mortada, N. Novel jojoba oil-based emulsion gel formulations for clotrimazole delivery. AAPS PharmSciTech, 2011, 12(1), 239-247. doi: 10.1208/s12249-011-9583-4 PMID: 21225383Anwar, S.; Jan, S.U.; Gul, R. Formulation and evaluation of celecoxib cream and its release study. Int. J. Curr. Pharm. Res., 2020, 12(5), 15-19. doi: 10.22159/ijcpr.2020v12i5.39757