Current Aging ScienceCurrent Aging ScienceCurrent Aging Science1874-60981874-6128Bentham Science64383310.2174/0118746098244014240119112706MedicineResearch ArticleNeuroprotective Effects of Curcumin against Chronic Chlorpyrifos- Induced Oxidative Damage in Rat Brain TissueFarkhondehTaherehinfo@benthamscience.netZardastMahmoudinfo@benthamscience.netRajabiShahnazinfo@benthamscience.netAbdollahi-KariznoMahdiinfo@benthamscience.netRoshanravanBabakinfo@benthamscience.netHavangiJalalinfo@benthamscience.netAschnerMichaelinfo@benthamscience.netSamarghandianSaeedinfo@benthamscience.netDepartment of Toxicology and Pharmacology, School of Pharmacy, Birjand University of Medical SciencesDepartment of Pathology, School of Medicine, Birjand University of Medical SciencesStudent Research Committee, Birjand University of Medical SciencesDepartment of Molecular Pharmacology, Albert Einstein College of MedicineHealthy Ageing Research Centre, Neyshabur University of Medical Sciences0103202417320520907012025Copyright ©; 2024, Bentham Science Publishers2024Bentham Science Publishershttps://journals.eco-vector.com/1874-6098/article/view/643833

Background:Chlorpyrifos (CPF) is an organophosphate pesticide that inhibits acetylcholinesterase (AChE) activity. Investigations have also focused on its neurotoxicity, which is independent of AChE inhibition. Here, we evaluated the effect of CPF on oxidative indices in the brain tissue and explored the protective effect of curcumin (Cur) against its toxicity.

Methods:Forty male Wistar rats were divided into five groups, each consisting of eight rats (n = 8) per group. Animals were administrated by oral gavage for 90 days with the following treatments: control (C), CPF, CPF + CUR 25 mg/kg, CPF + CUR50, and CPF + cur 100 received olive oil, CPF, CPF plus 25 mg/kg of CUR, CPF plus 50 mg/kg of CUR, and CPF plus 100 mg/kg of CUR, respectively. After anesthetization, animal brain tissues were obtained for assessment of oxidative stress indices.

Results:The concentration of MDA significantly increased in the brains of the CPF group as compared to the control group (p < 0.01). Also, a significant decrease in MDA concentrations was observed in the brains of rats in the CPF + Cur 100 group compared to the CPF group (p < 0.05). A significant decrease was noted in the GSH concentration in the brains of the CPF group compared to the control group (p < 0.05). Treatment with Cur at 100 mg/kg exhibited a significant increase in GSH concentrations in the brains of the CPF-exposed group compared to the CPF group without Cur administration (p < 0.05). The concentration of NO exhibited a significant increase in the brains of the CPF group when compared to the control group (p < 0.05). Also, a significant decrease in NO concentration was observed in the brain tissue of the CPF + Cur 100 group compared to the CPF group (p < 0.05).

Conclusion:Our data establish that chronic exposure to CPF induced oxidative stress in brain tissue, which was reversed by CUR administration. Additional experimental and clinical investigations are needed to validate the efficacy of CUR as a potential antidote for CPF poisoning.

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