THE ROLE OF THE COMPROMISED CYTOKINE STATUS IN PATHOGENESIS OF LATE VITREORETINAL COMPLICATIONS OF RETINOPATHY IN PREMATURE INFANTS

Abstract


A total of 44 patients at the age from 5 months to 22 years presenting with cicatrical and regressive stages of grade I-V retinopathy of prematurity (ROP) were available for the examination. The levels of 9 cytokines and growth factors were measured in their sera with the use of the flow cytofuorimetric technique and multiplex analysis. The patients were allocated to four groups dpending on the presence and character of late vitreoretinal complications of ROP. It was shown that the deficiency of tumour necrosis factor beta-1 of all the parameters studied responsible for the development of dystrophy and retinal detachment constitutes the most important defect in the immunoregulatory system. The enhanced systemic production of VEGF and proinflammatory cytokines was the aggravating factor.

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L. A Katargina

Moscow Helmholtz Research Institute of Eye Diseases


O. S Slepova

Moscow Helmholtz Research Institute of Eye Diseases


M. V Belova

Moscow Helmholtz Research Institute of Eye Diseases


A. E Andryushin

Moscow Helmholtz Research Institute of Eye Diseases


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