THE ROLE OF INFECTIOUS FACTORS IN THE DEVELOPMENT OF PROLIFERATIVE SYNDROME IN THE CHILDREN PRESENTING WITH ENDOGENOUS UVEITIS

Abstract


The present study included a total of 89 children presenting with uveitis of different localization and etiology. The objective of this work was to elucidate the relationship between the development of proliferative syndrome and infectious processes as well as to determine the serological markers of activation of ophthalmotropic infections (caused by type 1 and 2 herpes simplex viruses, cytomegalovirus, and Epstein-Barr virus, causative agents of toxoplasmosis, tuberculosis, toxocariasis, chlamydiasis, ureplasmosis, and mycoplasmosis). The patients with proliferative complications were shown to exhibit the highest frequency of infection with cytomegalovirus and Epstein-Barr virus in conjunction with reactivation of chronic infection with herpes simplex viruses. This finding suggests the possible influence of herpetic infections on the development of prolferative complications in the children with uveitis.

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About the authors

M. S Petrovskaya

Moscow Helmholtz Research Institute of Eye Diseases


E. V Denisova

Moscow Helmholtz Research Institute of Eye Diseases

Email: deale_2006@inbox.ru

O. S Slepova

Moscow Helmholtz Research Institute of Eye Diseases


L. A Katargina

Moscow Helmholtz Research Institute of Eye Diseases


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