Uveal melanoma in the children and adolescents: the analysis of the original observations of 21 patients


This article was designed to report the results of the retrospective analysis of 21 patients (13 boys and 8 girls) at the age varying from 1 to 20 years presenting with uveal melanoma. This group accounted for 1.36% of the total number of primary patients with uveal melanoma treated during the period from 2005 to 2012. The children and adolescents are known to most frequently present with non-pigmented and poorly-pigmented tumours. Morphologically, most of these neoplasms are spindle-cell tumours. It was shown that the majority of the patients with this pathology are referred to the specialized clinical centres at the late stages of the disease due to the absence of its early diagnostics and adequate examination of the children at the local ophthalmological facilities.

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About the authors

S. V Saakyan

The Helmholtz Moscow Research Institute of Eye Diseases

105062 Moscow, Russia

Anush Gamletovna Amiryan

The Helmholtz Moscow Research Institute of Eye Diseases

Email: amiryan@yandex.ru
105062 Moscow, Russia

A. Yu Tsygankov

The Helmholtz Moscow Research Institute of Eye Diseases

105062 Moscow, Russia


  1. Egan K.M., Seddon J.M., Glynn R.J., Graugudas E.S., Albert D.M. Epidemiologic aspects of uveal melanoma. Surv. Ophthalmol. 1988; 32, (4): 239-51.
  2. Sahel J.O., Steeves R., Albert D. Intraocular melanoma. In: De Vita V., Hellmann S., Rosenberg S.A. Cancer: Рrinciples and Рractice of Оncology. Philadelphia: Lippincott-Raven, 1997: 1995-2012.
  3. Bergman L., Seregard S., Nilsson B. Incidence of uveal melanoma in Sweden from 1960 to 1998. Invest. Ophthalmol. Vis. Sci.2002; 43: 2579-83.
  4. Гришина Е.Е., Федотова О.Ф., Житенев В.П. Анализ офтальмоонкологической патологии у взрослого населения Москвы по данным МОКБ. В кн.: Сборник научных трудов «Опухоли и опухолеподобные заболевания органа зрения». М.$ 1998: 23-4.
  5. Lutz J.M., Cree I.M., Foss A.J. Risk factors for intraocular melanoma and occupational exposure. Br. J. Ophthalmol. 1999; 83 (10): 1190-3.
  6. Ширина Т.В. Хориоидальные меланомы у молодых. Особенности диагностики. В кн.: Сборник трудов Юбилейной научно-практической конференции «Достижения и перспективы офтальмоонкологии». М.; 2001: 82-3.
  7. Apt L. Uveal melanomas in children and adolescents. Int. Ophthalmol. Clin. 1962; 2: 403-10.
  8. Barr C.C., McLean I.W., Zimmerman L.E. Uveal melanoma in children and adolescents. Arch. Ophthalmol. 1981; 99: 2133-6.
  9. Gailloud C., Zografos L., Bercher L., Uffer S., Egger E. Uveal melanomas in patients less than 20 years of age. Klin. Monatsbl. Augenheilkd. 1992; 200: 428-30.
  10. Gambrelle J., Dayan G., Baggetto L.G., Devouassoux-Shisheboran M. Uvealmelanoma in an 18-year-old Africanblackman. Acta Ophthalmol. Scand. 2005; 83 (1): 134-6.
  11. Hill J.C., Stannard C., Bowen R.M. Ciliary body malignant melanoma in a black child. J. Pediat. Ophthalmol. Strabismus. 1991; 28: 38-40.
  12. Leonard B.C., Shields J.A., McDonald P.R. Malignant melanomas of the uveal tract in children and young adults. Can. J. Ophthalmol. 1975; 10: 441-9.
  13. Pogrezebielski A., Orolwska-Heltzman J. Romanowska-Dixon B. Uveal melanoma in young patients. Grafe’s Arch. Clin. Ophthalmol. 2006; 244: 1646-9.
  14. Reeh M.J., Petersen P., Kobrin J.G. Chenoweth R.G. Malignant melanoma of choroid developing in the eye of a three-year-old boy. Ann. Ophthalmol. 1979; 11 (1); 57-70.
  15. Romanowska B., Zygulska-Mach H., Ksiezyk M. Survival rate of young patients with malignant choroidal melanoma after conservative treatment. Klin. Oczna. 1998; 100: 211-6.
  16. Rosenbaum P.S., Boniuk M., Font R.L. Diffuse uveal melanoma in a 5-year-old child. Am. J. Ophthalmol. 1988; 106: 601-6.
  17. Shields C.L., Shields J.A., Milite J. Uveal melanoma in teenagers and children. A report of 40 cases. Ophthalmology. 1991; 98: 1662-6.
  18. Singh A.D., Shields C.L., Shields J.A. Uveal melanoma in young patients. Arch. Ophthalmol. 2000; 118 (7): 918-23.
  19. Brodway D. Congenital malignant melanoma of the eye. Cancer. 1991; 67: 2642-52.
  20. Fledelius H., Land A.M. Malignant melanoma of the choroid in an 11-month-old infant. Acta Ophthalmol. (KBh). 1975; 53: 160-6.
  21. Greer C.H. Congenital melanoma of the anterior uvea. Arch. Ophthalmol. 1966; 76: 77-8.
  22. Palazzi M.A., Ober M.D., Abreu H.F. Congenital uveal malignant melanoma: a case report. Can. J. Ophthalmol. 2005; 40: 611-5.
  23. Posnick J.C., Chen P., Zuker R., Greenberg M.L., Becker L.E., Phillips J. Extensive malignant melanoma of the uvea in childhood: resection and immediate reconstruction with microsurgical and craniofacial techniques. Ann. Plast. Surg. 1993; 31: 265-70.
  24. Gonder J.R, Shields J.A., Albert D.M., Augsburger J.J., Lavin P.T. Uveal malignant melanoma associated with ocular and oculodermalmelanocytosis. Ophthalmology. 1982; 89: 953-60.
  25. Gunduz K. Choroidal melanoma in 14-year-old patient with ocular melanocytosis. Arch. Ophthalmol. 1998; 116 (8): 1112-4.
  26. Gunduz K., Shields C.L, Shields J.A., Eagle R.C. Iris Mammillations as the only sign of ocular melanocytosis in a child with choroidal melanoma. Arch. Ophthalmol. 2000; 118 (5): 716-7.
  27. Singh A.D., De Potter P., Fijal B.A., Shields C.L., Shields J.A., Elston R.C. Lifetime prevalence of uveal melanoma in white patients with oculo(dermal)melanocytosis. Ophthalmology. 1998; 105: 195-8.
  28. Verdaguer J.J. Prepuberal and puberal melanomas in ophthalmology. Am. J. Ophthalmol. 1965; 60: 1002-11.
  29. Greene M.H., Sanders R.J., Chu F.C. The familial occurrence of cutaneous melanoma, intraocular melanoma, and the dysplastic nevus syndrome. Am. J. Ophthalmol. 1983; 96: 238-45.
  30. Taylor M.R., Guerry D.V., Bondi E.E. Lack of association between intraocular melanoma and cutaneous dysplastic nevi. Am. J. Ophthalmol. 1984; 98: 478-82.
  31. Singh A.D., Shields C.L., Shields J.A., Eagle R.C., De Potter P. Uveal melanoma and familial atypical mole and melanoma (FAM-M) syndrome. Ophthalm. Genet. 1995; 16: 53-61.
  32. Vavvas D., Kim I., Lane A.M., Chaglassian A., Mukai S., Gragoudas E. Posterior uveal melanoma in young patients treated with proton beam therapy. Retina. 2010; 30 (8): 1267-71.
  33. Chao C., Martin R.C. II, Ross M.I. Correlation between prognostic factors and increasing age in melanoma. Ann. Surg. Oncol. 2004; 11: 259-64.
  34. Conway W.C., Faries M.B., Nicholl M.B. Age-related lymphatic dysfunction in melanoma patients. Ann. Surg. Oncol. 2009; 16: 1548-52.
  35. Balch C.M., Soong S.J., Gershenwald J.E. Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J. Clin. Oncol. 2001; 19: 3622-34.
  36. Strouse J.J., Fears T.R., Tucker M.A., Wayne A.S. Pediatric melanoma: risk factor and survival analysis of the surveillance, epidemiology and end results database. J. Clin. Oncol. 2005; 23: 4735-41.



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