Animal models of chronic pain. In vivo experiments

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Abstract


As a result of population aging and increasing of comorbide patients procent, chronic pain nowadays is the one of the most important medical problems and its treatment becoming one of progressive and popular researching topics. First part of acute or chronic pain research is a model that meets the specified criteria. First model of cronic pain – sciatic nerve damaging was founded and proven more than 30 years ago. Nowadays there is a lot of in vivo and in vitro models that matched with different pathologies and also mechanisms of chronic nociceptive and neuropathic pain on different levels have been learned. In this article we review the most effective and often used rat models of chronic pain its mechanisms and assessment methods. The information based on the most citated articles for 10 years.


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About the authors

V. V. Khinovker

Federal Siberian Research Clinical Centre FMBA of Russia; Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky

Author for correspondence.
Email: vhinov@hotmail.com
ORCID iD: 0000-0002-3162-6298

Russian Federation, Krasnoyarsk

к. мед. н., заведующий отделением анестезиологии и реанимации

E. V. Khinovker

Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky

Email: vhinov@hotmail.com
ORCID iD: 0000-0002-8860-9480

Russian Federation, Krasnoyarsk

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Supplementary files

Supplementary Files Action
1.
Segregation and ligation of sciatic nerve for neuropathic pain modeling

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2.
Intraoral

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3.
A few mm from the upper edge of the orbit

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