Vol 7, No 2 (2013)

The prospective clinical study was conducted in 150 female patients in early postoperative period after plastic and aesthetic surgeries. The analgesic effect and tolerability of nefopam hydrochloride within first hours following the surgery were evaluated. Nefopam hydrochloride was found to be a safe and useful adjunct to therapy for mild and moderate pain after plastic surgeries. Intramuscular injection of nefopam was associated with hemodynamic effects such as tachycardia and high blood pressure. These side effects should be accounted in postoperative pain management in patients with heart rate disorders, coronary heart disease, and hypertension.

The goal of the study was to compare the efficacy of three methods of anesthesia in patients operated on distal part of the lower extremities: isolated spinal anesthesia, spinal anesthesia in combination with local anesthesia performed at surgery zone and combination of spinal anesthesia and peripheral nerves blocks. The study was involved 75 patients undergone surgery distal part of the lower extremities stratified for method of anesthesia into three comparable groups. It was proved that the combination of spinal anesthesia with blockade of nerves of the bottom extremity is the most appropriate technique. This type of anesthesia allows not only to quit the pain effectively but also to provides stable indicators of a neurovegetative homeostasis and allow to reache positive hemorheological effects in the early postoperative period.

Anesthetic concentration of local anesthetics is often applied in analgesic regimens, including combination of general anesthesia and epidural or peripheral blocks. The author proposes to apply only analgesic concentrations of local anesthetics during such kind of combined analgesia while performing neural anesthesia if it is indicated individually.

The study is dedicated to Romanian school history of regional anesthesia. The author describes several interesting historical facts that were valuable for successful developing of methods of regional anesthesia at the beginning of XX century in Romania and Europe in general. An outstanding Romanian surgeon Tome Ionnesko made a great contribution in popularizing and developing new methods of anesthesia and applyed them widely in his own surgical practice.