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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Volgograd State Medical University</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Volgograd State Medical University</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Волгоградского государственного медицинского университета</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-9480</issn><issn publication-format="electronic">1994-9499</issn><publisher><publisher-name xml:lang="en">Volgograd State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">117708</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Importance of cytokine evaluation in obstructive uropathy in children</article-title><trans-title-group xml:lang="ru"><trans-title>ЗНАЧЕНИЕ ОПРЕДЕЛЕНИЯ УРОВНЕЙ ЦИТОКИНОВ ПРИ ОБСТРУКТИВНЫХ УРОПАТИЯХ У ДЕТЕЙ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Khvorostov</surname><given-names>N</given-names></name><name xml:lang="ru"><surname>Хворостов</surname><given-names>Н</given-names></name></name-alternatives><bio xml:lang="ru"><p>НИИ педиатрии Научный центр здоровья детей РАМН</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zorkin</surname><given-names>S N</given-names></name><name xml:lang="ru"><surname>Зоркин</surname><given-names>С Н</given-names></name></name-alternatives><bio xml:lang="ru"><p>НИИ педиатрии Научный центр здоровья детей РАМН</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Smirnov</surname><given-names>I E</given-names></name><name xml:lang="ru"><surname>Смирнов</surname><given-names>И Е</given-names></name></name-alternatives><bio xml:lang="ru"><p>НИИ педиатрии Научный центр здоровья детей РАМН</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Khvorostov</surname><given-names>I N</given-names></name><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Zorkin</surname><given-names>S N</given-names></name><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Smirnov</surname><given-names>I E</given-names></name><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">НИИ педиатрии Научный центр здоровья детей РАМН</institution></aff></aff-alternatives><aff id="aff2"><institution></institution></aff><pub-date date-type="pub" iso-8601-date="2005-02-15" publication-format="electronic"><day>15</day><month>02</month><year>2005</year></pub-date><volume>2</volume><issue>2</issue><issue-title xml:lang="en">NO2 (2005)</issue-title><issue-title xml:lang="ru">№2 (2005)</issue-title><fpage>45</fpage><lpage>49</lpage><history><date date-type="received" iso-8601-date="2022-12-16"><day>16</day><month>12</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2005, Khvorostov N., Zorkin S.N., Smirnov I.E., Khvorostov I.N., Zorkin S.N., Smirnov I.E.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2005, Хворостов Н., Зоркин С.Н., Смирнов И.Е., Khvorostov I.N., Zorkin S.N., Smirnov I.E.</copyright-statement><copyright-year>2005</copyright-year><copyright-holder xml:lang="en">Khvorostov N., Zorkin S.N., Smirnov I.E., Khvorostov I.N., Zorkin S.N., Smirnov I.E.</copyright-holder><copyright-holder xml:lang="ru">Хворостов Н., Зоркин С.Н., Смирнов И.Е., Khvorostov I.N., Zorkin S.N., Smirnov I.E.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.eco-vector.com/1994-9480/article/view/117708">https://journals.eco-vector.com/1994-9480/article/view/117708</self-uri><abstract xml:lang="ru"><p>1. Increased TFR-β 1 production in blood plasma of patients with obvtructive uropathy is an indicator of fibrogenetic activity. 2. FNO-α production is elevated upon exacerbation of chronic pyelonephritis. 3. Increased FNO-α excretion and decreased IL-10 excretion with urine is an indicator of nephrosclerosis in reflux nephropathy. 4. Irogressing nephrosclerosis with transformation to HPN is accompanied by decreased TFR-β 1 concentration in blood plasma. 5. Variations of the inflammatory index in the dynamics of disease underlie the processes of renal parenchyma lesions in children with obstructive uropathy.</p></abstract></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Кириллов В.И. Патогенетические основы иммунокорригирующей терапии пиелонефрита у детей: дис. ... д-ра мед. наук. М., 1990. 212 с.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Пальцев М.А., Иванов А.А. Межклеточные взаимодействия. М.: Медицина, 1995. 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