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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Volgograd State Medical University</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Volgograd State Medical University</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Волгоградского государственного медицинского университета</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-9480</issn><issn publication-format="electronic">1994-9499</issn><publisher><publisher-name xml:lang="en">Volgograd State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">117784</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Effect of quinapril on endothelial disfunction of arteriesand functional condition of callicreine-kinine systemin patients with arterial hypertension</article-title><trans-title-group xml:lang="ru"><trans-title>Влияние квинаприла на эндотелиальную дисфункцию артерий и функциональное состояние калликреин-кининовой системы у больных артериальной гипертензией</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vorobiov</surname><given-names>S V</given-names></name><name xml:lang="ru"><surname>Воробьев</surname><given-names>С В</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ростовский государственный медицинский университет</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>M ishina</surname><given-names>E V</given-names></name><name xml:lang="ru"><surname>Мишина</surname><given-names>Е В</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ростовский государственный медицинский университет</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Siritzina</surname><given-names>J V</given-names></name><name xml:lang="ru"><surname>Сирицына</surname><given-names>Ю В</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ростовский государственный медицинский университет</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gusova</surname><given-names>Z R</given-names></name><name xml:lang="ru"><surname>Гусова</surname><given-names>З Р</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ростовский государственный медицинский университет</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Egorova</surname><given-names>N A</given-names></name><name xml:lang="ru"><surname>Егорова</surname><given-names>Н А</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ростовский государственный медицинский университет</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Ростовский государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2006-01-15" publication-format="electronic"><day>15</day><month>01</month><year>2006</year></pub-date><volume>3</volume><issue>1</issue><issue-title xml:lang="en">NO1 (2006)</issue-title><issue-title xml:lang="ru">№1 (2006)</issue-title><fpage>41</fpage><lpage>45</lpage><history><date date-type="received" iso-8601-date="2022-12-16"><day>16</day><month>12</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2006, Vorobiov S.V., M ishina E.V., Siritzina J.V., Gusova Z.R., Egorova N.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2006, Воробьев С.В., Мишина Е.В., Сирицына Ю.В., Гусова З.Р., Егорова Н.А.</copyright-statement><copyright-year>2006</copyright-year><copyright-holder xml:lang="en">Vorobiov S.V., M ishina E.V., Siritzina J.V., Gusova Z.R., Egorova N.A.</copyright-holder><copyright-holder xml:lang="ru">Воробьев С.В., Мишина Е.В., Сирицына Ю.В., Гусова З.Р., Егорова Н.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.eco-vector.com/1994-9480/article/view/117784">https://journals.eco-vector.com/1994-9480/article/view/117784</self-uri><abstract xml:lang="ru"><p>The effect of quinapril on endothelial disfunction of arteries and functional condition of callicreine-kinine system in 38 patients with arterial hypertension was shown in the study. It was demonstrated that in patients with arterial hypertension endothelial disfunction is related to the changes in the system of the enzymatic cascade of bradikinine accumulation. The combined effect of studied indices on the developing endothelial disfunction in patients with arterial hypertension was significant. Estimation of prognostic value of changes in the callicreine-kinine system components in patients with arterial hypertension revealed that a decrease of precallicreine concentration in endothelial lesions is the most significant factor. In patients with arterial hypertension changes of vasodilating endothelium function were associated with the restoration of activity of callicreine-kinine system.</p></abstract><kwd-group xml:lang="en"><kwd>arterial hypertension</kwd><kwd>callicreine-kinine system</kwd><kwd>endothelium-dependent vasodilatation</kwd><kwd>quinapril</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Балахонова Т.В., Погорелова О.А., Алидшанова Х.Т. и др. // Тер. архив. - 1998. - № 4. - С. 15-19.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Воробьев С.В., Микашинович З.И., Черногубова Е.А. и др. Способ определения эндотелиальной дисфункции. 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