Journal of Volgograd State Medical UniversityJournal of Volgograd State Medical University1994-94801994-9499Volgograd State Medical University119017Research ArticleA MODERN VIEW ON THE MECHANISMS AND CLASSIFICATION OF CELL DEATHDvoryashinaI. A.germionna@yandex.ruVelikorodnayaYu. I.-PocheptsovA. Ya.-FedorovaO. V.-Volgograd State Medical UniversityFGUP «Research Institute of Hygiene, Toxicology and Occupational Pathology» FMBA of Russia1503201613313713917122022Copyright © 2016, Dvoryashina I.A., Velikorodnaya Y.I., Pocheptsov A.Y., Fedorova O.V.2016The article includes recommendations of the Nomenclature Committee on Cell Death on irreversible permeabilization of the cell membrane or complete fragmentation of cells as well as regulated cell death (a genetically regulated process). The article describes morphological, biochemical and immunohistochemical markers of apoptosis, necrosis, autophagy and anoikis.cell deathapoptosisnecrosisautophagyanoikisклеточная гибельапоптознекрозаутофагияаноикис[Galluzzi L., Bravo-San Pedro J. M., Vitale I., Aaronson S. A., et al. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 // Cell Death and Differentiation. - 2015. - Vol. 22. - Р 58-73.][Jiao Zhang, Ling Guo, Xia Zhou, Fengyun Dong, Liqun Li, Zuowang Cheng, Yinghua Xu, Jiyong Liang, Qi Xie, and Ju Liu. Dihydroartemisinin induces endothelial cell anoikis through the activation of the JNK signaling pathway // Oncol Lett. - 2016. - Sep; Vol. 12 (3). - Р 1896-1900.][Galluzzi L., Vitale I., Abrams J. M., Alnemri E. S., Baehrecke E. H., Blagosklonny M. V., et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death // Cell Death Differ. - 2012. - Vol. 19. - Р 107-120.][Kerr J. F., Wyllie A. H., Currie A. R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics // Br J Cancer. - 1972. - Vol. 26. - Р 239-257.][Kroemer G., Galluzzi L., Vandenabeele P., Abrams J., Alnemri E. S., Baehrecke E. H., et al. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009 // Cell Death Differ. - 2009. - Vol. 16. - Р 3-11.][Антошкин О. Н., Загребин В. П., Волотова Е. В., Куркин Д. В., Бакулин Д. А., Федорова О. В., Терентьев А. В., Егорова А. С. Протеинопатия и апоптоз нейронов головного мозга при экспериментальной нейродегенерации у крыс // Вестник ВолгГМУ. - 2015. - № 1 (53). - С. 122-124.][Ковалева О. В., Шитова М. С., Зборовская И. Б. Аутофагия: клеточная гибель или способ выживания? // Клиническая онкогематология. - 2014. - Т. 7, № 2. - С. 103-113.][Манских В.Н. Пути гибели клеток и их биологическое значение // Цитология. - 2007. - Т. 49, № 11. - С. 909-915.]