Journal of Volgograd State Medical UniversityJournal of Volgograd State Medical UniversityВестник Волгоградского государственного медицинского университета1994-94801994-9499Volgograd State Medical University119063ArticlesСтатьиReview ArticleVISCERAL OBESITY AS A RISK MARKER OF MULTIORGAN DAMAGEВИСЦЕРАЛЬНОЕ ОЖИРЕНИЕ КАК МАРКЕР РИСКА МУЛЬТИОРГАННОГО ПОРАЖЕНИЯStatsenkoM. EСтаценкоМихаил Евгеньевич

д. м. н., профессор, заведующий кафедрой внутренних болезней педиатрического и стоматологического факультетов

mestatsenko@rambler.ruTurkinaS. VТуркинаС. ВTyshchenkoI. AТыщенкоИ. АGorbachevaE. EГорбачеваЕ. ЕErmolenkoA. AЕрмоленкоА. АVolgograd State Medical UniversityВолгоградский государственный медицинский университет15012017141NO1 (2017)№1 (2017)101518122022Copyright ©; 2017, Statsenko M.E., Turkina S.V., Tyshchenko I.A., Gorbacheva E.E., Ermolenko A.A.Copyright ©; 2017, Стаценко М.Е., Туркина С.В., Тыщенко И.А., Горбачева Е.Е., Ермоленко А.А.2017Statsenko M.E., Turkina S.V., Tyshchenko I.A., Gorbacheva E.E., Ermolenko A.A.Стаценко М.Е., Туркина С.В., Тыщенко И.А., Горбачева Е.Е., Ермоленко А.А.https://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/1994-9480/article/view/119063

This article presents a review of the relationship between visceral obesity and the occurrence of damage to the heart, kidneys, liver.

В статье представлен обзор, посвященный взаимосвязи висцерального ожирения и формирования поражения сердца, почек, печени.

visceral obesitycardiovascular riskchronic kidney diseasenon-alcoholic fatty liver diseaseвисцеральное ожирениесердечно-сосудистый рискхроническая болезнь почекнеалкогольная жировая болезнь печениГруздева О.В., Акбашева О.Е., Матвеева В.Г. и др. Цитокиновый профиль при висцеральном ожирении и неблагоприятный кардиоваскулярный прогноз инфаркта миокарда // Медицинская иммунология. - 2015. - № 17 (3). - Р. 211-220.Недогода С.В., Вёрткин А.Л., Наумов А.В. и др. Ожирение и коморбидная патология в практике поликлинического врача (определение, диагностика; немедикаментозное лечение; лечение ожирения и комор-бидной патологии) // Амбулаторный прием. - 2016. - Т. 2, № 1 (4) - 3(6).Стаценко М.Е., Деревянченко М.В., Шилина Н.Н. и др. Функциональное состояние почек у больных с сердечно-сосудистыми заболеваниями и ожирением // Нефрология. - 2016. - Т. 20 (5). - Р. 43-49.Abel E.D., Litwin S.E., Sweeney G. Cardiac Remodeling in Obesity // Physiological reviews. - 2008. - Vol. 88(2). - P. 389-419.Al-Daghri N.M., Al-Attas O.S., Alokail M.S., et al. Visceral adiposity index is highly associated with adiponectin values and glycaemic disturbances // Eur. J. Clin. Invest. 2013. - Vol. 43(2). - Р. 183-189.Amato M.C., Giordano C., Galia M., et al. Visceral adiposity index: are liable indicator of visceral fat function associated with cardio-metabolic risk // DiabetesCare. - 2010. - Vol. 33(4). - Р. 920-922.Amato M.C., Giordano C., Pitrone M., Galluzzo A. Cutoff points of the visceral adiposity index (VAI) identifying a visceral adipose dysfunction associated with cardiometabolic risk in a Caucasian Sicilian population // Lipids Health Dis. - 2011. - Vol. 10. - Р. 183.Amato М.С., Giordano С. Visceral Adiposity Index: An Indicator of Adipose Tissue Dysfunction Hindawi Publishing Corporation International // Journal of Endocrinology. - 2014. ArticleID 730827, 7.Andreas L. Birkenfeld, Gerald I. Shulman. Non Alcoholic Fatty Liver Disease, Hepatic Insulin Resistance and Type 2 Diabetes // Hepatology. - 2014. February. - Vol. 59 (2). - Р. 713-723.Baker A.R., Silva N.F., Quinn D.W., et al. Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease // Cardiovasc. Diabetol. - 2006. - Vol. 13 (5). - Р. 1-16.Carmine Finelli. Dealing with the visceral fat reduction to slow the progression of NAFLD. Surgery for Obesity and Related Diseases. http//dx. doi.org/10.101.1016/ j.soard.2016.12.021/Choquet Helene, Meyre David. Geneticsof Obesity: What have we Learned? // CurrGenomics. - 2011, May. - Vol. 12 (3). - Р. 169-179.Christopher X. Wong, Rajiv Mahajan, Rajeev Pathak, et al. The Role of Pericardial and Epicardial Fat in Atrial Fibrillation Pathophysiology and Ablation Outcomes // Journal of Atrial Fibrillation. - 2013. - Vol. 5 (5). - Р. 37-43.Corradi D., Maestri R., Callegari S., et al. The ventricular epicardial fat is related to the myocardial mass in normal, ischemic and hypertrophic hearts // Cardiovasc. Pathol. - 2004. - Vol. 13. - Р. 313-316.D’Elia, J.A., Roshan, B., Maski, M., et al. Manifestation of renal disease in obesity: pathophysiology of obesity-related dysfunction of the kidney // International Journal of Nephrology and Renovascular Disease. - 2009. - Vol. 2. - Р. 39-49.Dowman J.K., Tomlinson J., Newsome P. Pathogenesis of non-alcoholic fatty liver disease // Qjm. - 2010. - Vol. 103(2). - Р. 71-83.Fernandez-Alfonso M.S., Gil-Ortega M., Garcia-Prieto C.F., et al. Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity // International Journal of Endocrinology. - 2013. - Vol. 2013. - Р. 1-8.Fitzgibbons Timothy P., Czech Michael P. Epicardial and Perivascular Adipose Tissues and Their Influence on Cardiovascular Disease: Basic Mechanisms and Clinical Associations // J Am Heart Assoc. - 2014. - Vol. 3. - Р. e000582.Foster Michelle T., Pagliassotti Michael J. Metabolic alterations following visceral fat removal and expansion. Beyond anatomic location // Adipoсyte. - 2012. - Vol. 1 (4). - Р. 1-8.Gallagher D., Kelley D.E., Yim J.E., et al. Adipose tissue distribution is different in type 2 diabetes // American Journal of Clinical Nutrition. - 2009. - Vol. 89 (3). - Р. 807-814.Garvey W., et al. American Association of Clinical Endocrinologists and American College of Endocrinology Position Statement on the 2014 Advanced Framework for a New Diagnosis of Obesity as a Chronic Disease // Endocrine Practice. 2014.Greenstein A.S., Khavandi K., Withers S.B., et al. Local Inflammation and Hypoxia Abolish the Protective Anticontractile Properties of Perivascular Fat in Obese Patients // Circulation. - 2009. - Vol. 119(12). - Р. 1661-70.Guzzardi M.A., lozzo P. Fatty Heart, Cardiac Damage, and Inflammation // The Review of Diabetic Studies: RDS. - 2011. - Vol. 8 (3). - Р. 403-417.Hans Hauner. Secretory factors from human adipose tissue and their functional role // Nutrition Society. - 2005. - Vol. 64. - Р. 163-169.Hausman G.J., Basu U., Du M., et al. Inter muscular and intramuscular adipose tissues: Bad vs. Good adipose tissues // Adipocyte. - 2014. - Vol. 3(4). - Р. 242-255.Henegar J.R., Bigler S.A., Henegar L.K., et al. Functional and Structural Changesin the Kidney in the Early Stages of Obesity // J Am Soc Nephrol. - 2001. - Vol. 12. - Р. 1211-1217.Hyo Eun Park, Su-Yeon Choi, Minkyung Kim. Association of epicardial fat with left ventricular diastolic function in subjects with metabolic syndrome: assessment u s in g 2 - d im en s io n a l ec h o c ard io grap hy B M C // Cardiovascular Disorders. - 2014. - Vol. 14. - Р. 3-6.Iacobellis G., Sharma A.M. Epicardial adipose tissue as new cardio-metabolic risk marker and potential therapeutic target in the metabolic syndrome // Current Pharmaceutical Design. - 2007. - Vol. 13 (21). - Р. 2180-2184.lacobellis G., Barbaro G. The double role of epicardial adipose tissue as pro- and anti-inflammatory organ // Hormone and Metabolic Research 2008. - Vol. 40 (7). - Р. 442-445.Jensen M. D. Role of Body Fat Distribution and the Metabolic Complications of Obesity // The Journal of Clinical Endocrinology and Metabolism. - 2008. - Vol. 93 (11, Supplю 1). - Р. S57-S63.Kahan S., Zvenyach T. Obesity as a Disease: Current Policies and Implications for the Future // Curr Obes Rep?DOI 10.1007/s13679-016-0218-7.Kang S.H., Cho K.H., Park J.W., et al. Association of Visceral Fat Area with Chronic Kidney Disease and Metabolic Syndrome Risk in the General Population: Analysis Using Multi-Frequency Bioimpedance // Kidney Blood Press Res. - 2015. - Vol. 40. - Р. 223-230.Matsuzawa Y. The role of fat topology in the risk of disease // Review. International Journal of Obesity. - 2008. - Vol. 32. - Р. 83-92.Mirza M.S. Obesity, Visceral Fat and NAFLD: Querying the Role of Adipokines in the Progression of Nonalcoholic Fatty Liver Disease ISRN // Gastroenterology. - 2011. doi. 10.5402/2011/5924.Montani, J.P. Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases / J.P. Montani, J.F. Carroll, T.M. Dwyer // Int J Obes Relat Metab Disord. - 2004. - Vol. 28. - Р. 58-65.Nakamura T., Tokunaga K., et al. Contribution of visceral fat accumulation to the development of coronary artery disease in non-obese men // Atherosclerosis. 1994. - Vol. 107. - Р. 239-246.Ou H.-Y., Wang C.-Y., Yang Y.-C., et al. The Association between Nonalcoholic Fatty Pancreas Disease and Diabetes // PLoSONE. - 2013. - Vol. 8 (5). - Р. e62561.Rabkin S.W. Epicardial fat: properties, function and relationship to obesity // Obesity Reviews. - 2007. - Vol. 8 (3). - Р. 253-261.Sacks H.S., Fain J.N. Human epicardial adipose tissue: areview // American Heart Journal. - 2007. - Vol. 153(6). - Р. 907-917.Sharma S., Adrogue J.V., Golfman L., et al. Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart // FASEBJ. - 2004. - Vol. 18. - Р. 1692-700.Su Jong Yu, Won Kim, Donghee Kim, et al. Visceral Obesity Predicts Significant Fibrosis in Patients With Nonalcoholic Fatty Liver // Disease Medicine. - 2015. - Vol. 94 (48). - Р. e2159.Tokunaga K., Matsuzawa Y., Ishikawa K., Tarui S. Novel technique for the determination of body fat by computed tomography // International Journal of Obesity. - 1983. - Vol. 7. - Р. 437-445.Vivette D. D’Agati, Avry Chagnac, Aiko P.J. de Vries, et al. Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis // Nature Reviews Nephrology. - 2016. - Vol. 12. - Р. 453-471.Wickman Christopher, Kramer Holly. Obesity and Kidney Disease: Potential Mechanisms // Semin Nephrol. - 2013. - Vol. 33. - Р. 14-22.Wolf Gunter, Ziyadeh Fuad N. Leptin and Renal Fibrosis. Wolf G (ed): Obesity and the Kidney //?Contrib Nephrol. Basel, Karger. - 2006. - Vol. 151. - Р. 175-183.www. who. Int.Zhang H., Park Y., Wu J., et al. Role of TNF-a in vascular dysfunction // Clinical Science. - 2009. - Vol. 116 (3). - Р. 219-230.