Journal of Volgograd State Medical UniversityJournal of Volgograd State Medical University1994-94801994-9499Volgograd State Medical University11919110.19163/1994-9480-2017-4(64)-90-95Research ArticleCOMPARATIVE ANALYSIS OF THE CATALYTIC ACTIVITY OF HIGHLY PURIFIED HUMAN BUTYRYLCHOLINESTERASE IN NATIVE AND CONJUGATED GOLD NANOPARTICLES IN VIVOSokolovO. I.-SelivanovN. Y.-SelivanovaO. G.-VelikorodnayaYu. I.velikorodnaya@rihtop.ruDykmanL. A.-BogatyrevV. A.-PocheptsovA. Ya.-FilatovB. N.-Institute of Biochemistry and Physiology of Plants and Microorganisms of the Russian Academy of SciencesScientific Research Institute of Hygiene, Toxicology and Occupational Pathology of the FMBA15042017144909518122022Copyright © 2017, Sokolov O.I., Selivanov N.Y., Selivanova O.G., Velikorodnaya Y.I., Dykman L.A., Bogatyrev V.A., Pocheptsov A.Y., Filatov B.N.2017The paper presents a comparative analysis of the effect of two forms of highly purified butyrylcholinesterase: native and conjugated with gold nanoparticles on the dynamics of cholinesterase activity in blood plasma and target organs. The results of the experiment showed that the peak of cholinesterase activity was observed 24 hours after administration of the native butyrylcholinesterase. The conjugated form of butyrylcholinesterase showed a small but stable increase in the cholinesterase level over a longer time (up to 3 days).butyrylcholinesteraseacetylcholinesterasegold nanoparticlesconjugationactivityбутирилхолинэстеразаацетилхолинэстеразананочастицы золотаконъюгацияактивность[Гайер Г. Электронная гистохимия. - М.: Мир, 1974. - С. 488.][Соколов О.И., Селиванов Н.Ю., Богатырев В.А., Селиванова О.Г. и др. Получение и изучение каталитической активности высокоочищенной бутирилхолинэстеразы человека, конъюгированной с наночастицами золота // Доклады Академии наук. - 2016. - Т. 468 (6). - С. 713-715.][Ding S., Cargill A.A., Medintz I.L., Claussen J.C. // Curr. Opin. Biotechnol. - 2015. - Vol. 34. - P. 242-250.][Frens G. // Nature Phys. Sci. - 1973. - Vol. 241. - P. 20-22.][Khlebtsov N.G., Dykman L.A. // J. Quant. Spectrosc. Radiat. Transfer. - 2010. - Vol. 111. - P. 1-35.][Mesulam M., Guillozet A., Shaw P., Quinn B. // J. Neurobiol. Dis. - 2002. - Vol. 9. - P. 88-93.][Nadorp B., Soreq H. // Frontiers in Molecular Neuroscience. -2014. - Vol. 7. - Р. 55-65.]