Journal of Volgograd State Medical UniversityJournal of Volgograd State Medical University1994-94801994-9499Volgograd State Medical University11948310.19163/1994-9480-2020-3(75)-159-165Research ArticlePARADOXAL ACTIVITY OF AMINOGUANIDINE IN THE MODEL OF GLYCOXIDATION WITH COPPER CATIONSLitvinovR. ALaboratory of metabotropic drugs Scientific Center for Innovative Drugs VolgSMUlitvinov.volggmu@mail.ruUsmiyanovaL. ELaboratory of metabotropic drugs Scientific Center for Innovative Drugs VolgSMU-KlimenkoD. RLaboratory of metabotropic drugs Scientific Center for Innovative Drugs VolgSMU-GontarevaA. V.Laboratory of metabotropic drugs Scientific Center for Innovative Drugs VolgSMU-FSBEI HE «Volgograd State Medical University» of the Ministry of Healthcare of the Russian FederationVolgograd medical scientific center, laboratory of experimental pharmacology1503202017315916518122022Copyright © 2020, Litvinov R.A., Usmiyanova L.E., Klimenko D.R., Gontareva A.V.2020The well-known inhibitor of advanced glycation-end products (AGEs) formation aminoguanidine, was studied using a previously tuned model of glycoxidation in copper-contained media (glucose 0,5 M, HEPES 0,1 M, CuSO4x5H2O 40 μM). As a result of the research, it was confirmed that aminoguanidine (1, 3, 10 mM) under conditions of glyoxidation with copper does not suppress the formation of argpyrimidine by detection of argpirimidine's self-fluorescence (Aex 330 nm, Aem 360-450 nm). 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