Journal of Volgograd State Medical UniversityJournal of Volgograd State Medical University1994-94801994-9499Volgograd State Medical University11963710.19163/1994-9480-2021-2(78)-78-82Research ArticleCLINICAL CASE OF THREE-WAVE HYPEREOSINOPHILIA IN A BOY IN THE DYNAMICS OF OBSERVATIONZriachkinN. Inizryach@yandex.ruBuchkovaT. N-KushnerevaT. T-FSBEI HE «V. I. Razumovsky Saratov state medical University» Ministry of health of the Russian FederationSHI «Novouzenskaya district hospital»15022021182788219122022Copyright © 2021, Zriachkin N.I., Buchkova T.N., Kushnereva T.T.2021The wide spread of parasitic infestations determines the relevance of the problem. Parasitic hypereosinophilia accounts for 17-25 % of large eosinophilia. The peculiarity of the presented clinical case is three waves of hypereosinophilia. The first hypereosinophilia was detected at the age of 8 years against the background of a massive mixed invasion (ascaridosis and enterobiosis), and antibodies to ascarids and helminth eggs were not detected in the feces. Tangle ascarids and pinworms departed after taking nemasole. The second wave of hypereosinophilia was diagnosed at the age of 10 years against the background of opisthorchiasis (IgG - 1:400 antibody titer). The third wave of hypereosinophilia was established at the age of 11 years and 6 months against the background of toxocarosis and Giardia (antibodies to toxocars and Giardia in the diagnostic titer in August 2018) and hypereosinophilia persisted until December 26, 2019.childrenhypereosinophilic syndromemixed helminth infestationparasitosisopisthorchiasisascariasisenterobiosistoxocarosisgiardiasisдетигиперэозинофильный синдромсмешанная глистная инвазияпаразитозописторхозаскаридозэнтеробиозтоксокарозлямблиоз[Аллергология и иммунология / под ред. Р.М. Хаитова, Н. И. Ильиной. - М.: ГЭОТАР-Медиа, 2014. - 656 с. - (Серия «Национальные руководства»).][Диагностика и лечение лямблиоза у детей: учебное пособие / под ред. Н. Захаровой. - М.: ГбОу ДПО РМАПО, 2015. - 113 с.][Зрячкин Н.И., Цека Ю.С. Лямблиоз у детей. Методические рекомендации. - Саратов: Изд-во СГМУ, 2013. - 31 с.][Медицинская паразитология и паразитарные болезни / под ред. А.Б. Ходжаяна, С.С. Козлова, М.В. Голубевой. - М.: ГЭОТАР-Медиа, 2014. - 448 с.][Aaron Dora-Laskey, Jeter (Jay) Pritchard Taylor III (ed.) Ascaris Lumbricoides // Medscape. Drugs and Diseases. - URL: https://emedicine.medscape.com/article/788398-overview (date of viewing: 21.11.2014).][Wayne Wolfram, Russell W Steele (ed.) Enterobiasis // Medscape. Drugs and Diseases. - URL: https://emedicine.med-scape.com/article/997814-overview (date of viewing: 26.06.2013).][Sun Huh, Mark R Wallace (ed.) Toxocariasis // Med-scape. Drugs and Diseases. - URL: https://reference.med-scape.com/(date of viewing: 16.02.2016).]