Journal of Volgograd State Medical UniversityJournal of Volgograd State Medical University1994-94801994-9499Volgograd State Medical University13919410.19163/1994-9480-2022-19-4-157-161Research ArticleTHE VALUE OF PERIPHERAL BLOOD NK CELLS AND EXPRESSION OF TRANSFORMING GROWTH FACTOR BETA-1 IN RECURRENT OVARIAN 157 ENDOMETRIOSISPetrovskayaN. Nobstetrician-gynecologist of the Department of Gynecologydr.ramzaeva@mail.ruPechenikovaV. AMD, PhD, Professor of the Department of Obstetrics and Gynecologyp-vikka@mail.ruI.I. Mechnikov Northwestern State Medical University1512202219415716126012023Copyright © 2022, Petrovskaya N.N., Pechenikova V.A.2022Affiliation. Federal state budgetary educational institution of higher education «North-Western State Medical University named after I. I. Mechnikov» under the Ministry of Health of the Russian Federation, Saint-Petersburg Introduction. Elevated level of transforming growth factor-61 (TGF-61) can be the cause of impaired immune response among women with endometriosis due to its ability to reduce the activity of NK-cells, which contributes to the survival of ectopic endometrial cells in the abdominal cavity and plays a key role in the progression of the disease. Materials and methods. 196 endometrioma observations were studied, an immunological study of peripheral blood was performed with the determination of CD3-CD16/56+ (natural killers) and an IHC study of the expression of TGF-61 in the capsule of an endometrioid cyst and in a preserved cytogenic stroma. The IHC study showed that the expression area of TGF-61 was significantly larger in the surgical material in the recurrent course of endometriosis; an immunological study revealed a significant decrease in NKcells during the endo-metrioma recurrence. Conclusion: Further study of the relationship between TGF-61 and NK cells may be important as prognostic markers of recurrent endometriosis.ovarian endometrioid cystrelapseendometriomatransforming growth factor-61NK-cellsэндометриоидная киста яичникарецидивэндометриоматрансформирующий фактор роста-61NK-клетки[Behaviour of cytokine levels in serum and peritoneal fluid of women with endometriosis / A. Pizzo, F.M. Salmeri, F.V. Ardita [et al.] // Gynecol Obstet Invest. 2002. Vol. 54. P. 82-87.][Transforming growth factor-p induced Warburg-like metabolic reprogramming may underpin the development of peritoneal endometriosis / VJ. Young, J.K. Brown, J. Maybin [et al.] // J Clin Endocrinol Metab. 2014. Vol. 99. P. 3450-3459.][The peritoneum is both a source and target of TGF-p in women with endometriosis / VJ. Young, J.K. Brown, P.T. Saunders [et al.] // PLoS One. 2014. Vol. 9. P. e106773.][Флорова М.С. Роль ростовых факторов в патогенезе эндометриоза // Журнал акушерства и женских болезней. 2019. № 3 (68). С. 71-80.][Mizumoto Y. Changes in NK activities and TGF-beta concentration in the peritoneal cavity in endometriosis and their interaction related with infertility // J Reprod Immunol. 1997. No. 32 (3). P. 286-287. https://doi.org/10.1016/s0165-0378(97)82484-9.][Попова О.С. Клетки иммунной системы как биомаркеры в диагностике эндометриоза // Проблемы репродукции. 2019. № 2 (25). С. 8-15. https://doi.org/10.17116/repro2019250218.]