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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Volgograd State Medical University</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Volgograd State Medical University</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Волгоградского государственного медицинского университета</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-9480</issn><issn publication-format="electronic">1994-9499</issn><publisher><publisher-name xml:lang="en">Volgograd State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">630285</article-id><article-id pub-id-type="doi">10.19163/1994-9480-2024-21-1-30-34</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original Researches</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Quantitative criteria of morphologic analysis of Vogt’s polysad by optical coherence tomography method</article-title><trans-title-group xml:lang="ru"><trans-title>Количественные критерии морфологического анализа палисада Фогта методом оптической когерентной томографии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5311-0006</contrib-id><name-alternatives><name xml:lang="en"><surname>Ushakova</surname><given-names>Larisa I.</given-names></name><name xml:lang="ru"><surname>Ушакова</surname><given-names>Лариса Ивановна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Candidate of Medical Sciences, Head of the Ophthalmology Department</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, заведующий офтальмологическим отделением</p></bio><email>lelaushakova@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7786-5665</contrib-id><name-alternatives><name xml:lang="en"><surname>Solodkova</surname><given-names>Elena G.</given-names></name><name xml:lang="ru"><surname>Солодкова</surname><given-names>Елена Геннадиевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Candidate of Medical Sciences, Deputy Director for Scientific Work, Academician S.N. Fedorov Eye Microsurgery, Volgograd Branch; Associate Professor of the Department of Surgical Diseases No. 2, Institute of Continuing Medical and Pharmaceutical Education, Volgograd State Medical University</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, заместитель директора по научной работе, Микрохирургия глаза имени академика С.Н. Фёдорова, Волгоградский филиал; доцент кафедры хирургических болезней № 2, Институт непрерывного медицинского и фармацевтического образования, Волгоградский государственный медицинский университет</p></bio><email>solo23el@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5250-3692</contrib-id><name-alternatives><name xml:lang="en"><surname>Balalin</surname><given-names>Sergey V.</given-names></name><name xml:lang="ru"><surname>Балалин</surname><given-names>Сергей Викторович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Doctor of Medical Sciences, Professor of the Department of Surgical Diseases No. 2 Institute of Continuing Medical and Pharmaceutical Education, Volgograd State Medical University; Head of the Scientific Department, Eye Microsurgery named after Academician S.N. Fedorov, Volgograd Branch</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, профессор кафедры хирургических болезней №2 Институт непрерывного медицинского и фармацевтического образования, Волгоградский государственный медицинский университет; заведующий научным отделом, Микрохирургия глаза имени академика С.Н. Фёдорова, Волгоградский филиал</p></bio><email>s.v.balalin@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4557-4131</contrib-id><name-alternatives><name xml:lang="en"><surname>Melikhova</surname><given-names>Irina A.</given-names></name><name xml:lang="ru"><surname>Мелихова</surname><given-names>Ирина Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Ophthalmologist</p></bio><bio xml:lang="ru"><p>врач-офтальмолог</p></bio><email>melihova.ira@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2513-9709</contrib-id><name-alternatives><name xml:lang="en"><surname>Fokin</surname><given-names>Viktor P.</given-names></name><name xml:lang="ru"><surname>Фокин</surname><given-names>Виктор Петрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Doctor of Medical Sciences, Professor, Director</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, профессор, директор</p></bio><email>fokin@isee.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Eye Microsurgery named after Academician S.N. Fedorov, Volgograd branch</institution></aff><aff><institution xml:lang="ru">Микрохирургия глаза имени академика С.Н. Фёдорова, Волгоградский филиал</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Volgograd State Medical University</institution></aff><aff><institution xml:lang="ru">Волгоградский государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2024</year></pub-date><volume>21</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>30</fpage><lpage>34</lpage><history><date date-type="received" iso-8601-date="2024-04-12"><day>12</day><month>04</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-04-12"><day>12</day><month>04</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Ushakova L.I., Solodkova E.G., Balalin S.V., Melikhova I.A., Fokin V.P.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Ушакова Л.И., Солодкова Е.Г., Балалин С.В., Мелихова И.А., Фокин В.П.</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Ushakova L.I., Solodkova E.G., Balalin S.V., Melikhova I.A., Fokin V.P.</copyright-holder><copyright-holder xml:lang="ru">Ушакова Л.И., Солодкова Е.Г., Балалин С.В., Мелихова И.А., Фокин В.П.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.eco-vector.com/1994-9480/article/view/630285">https://journals.eco-vector.com/1994-9480/article/view/630285</self-uri><abstract xml:lang="en"><p>Fifty healthy individuals (50 eyes) from 22 to 60 years old were examined. The height and width of trabeculae of Vogt’s palisade, their number throughout 1 mm, as well as the thickness of the limbal epithelial layer were determined in all patients, tear production was analyzed according to the results of Schirmer I test. With increasing age there was a significant decrease in the number of trabeculae in Vogt’s palisade: from 11,1 ± 0,99 to 6,7 ± 0,82 (<italic>p</italic> &lt; 0,001). In patients older than 45 years, there was also a significant decrease in the thickness of trabeculae and an increase in the thickness of the limbal epithelial layer (<italic>p</italic> &lt; 0.001). The coefficient reflecting the state of the limbal zone palisade architectonics depending on the patient’s age was determined, which will allow to estimate the influence of age on the limbal zone state in each specific case.</p></abstract><trans-abstract xml:lang="ru"><p>Обследованы 50 здоровых лиц (50 глаз) от 22 до 60 лет. У всех пациентов определяли высоту и ширину трабекул палисада Фогта, их количество на протяжении 1 мм в верхних и нижних отделах лимба, а также толщину эпителиального слоя лимбальной зоны, проводили анализ слезопродукции по результатам проведения пробы Ширмера I. С увеличением возраста было отмечено достоверное уменьшение количества трабекул в палисаде Фогта: с 11,1 ± 0,99 до 6,7 ± 0,82 (<italic>p</italic> &lt; 0,001). У пациентов старше 45 лет отмечалось также достоверное уменьшение толщины трабекул и увеличение толщины эпителиального слоя лимбальной зоны (<italic>p</italic> &lt; 0,001). Определен коэффициент, отражающий состояние архитектоники палисада лимбальной зоны в зависимости от возраста пациента, что позволит в каждом конкретном случае оценивать влияние возраста на состояние лимбальной зоны.</p></trans-abstract><kwd-group xml:lang="en"><kwd>optical coherence tomography of the cornea</kwd><kwd>Vogt’s palisades in healthy individuals</kwd><kwd>Schirmer’s test</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>оптическая когерентная томография роговицы</kwd><kwd>палисады Фогта у здоровых лиц</kwd><kwd>проба Ширмера</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Sinelnikov R.D., Sinelnikov Ya.R., Sinelnikov A.Ya. Atlas of human anatomy. Textbook. In 4 vol. Vol. 3. Moscow, 2010. 312 p. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Синельников Р.Д., Синельников Я.Р., Синельников А.Я. Атлас анатомии человека: учебное пособие. В 4 т. Т 3. М.: 2010. 312 с.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Vogt A. Atlas of the Slitlamp-Microscopy of the Living Eye. Berlin: Springer-Verlag; 1921. 23 p.</mixed-citation><mixed-citation xml:lang="ru">Vogt A. Atlas of the Slitlamp-Microscopy of the Living Eye. Berlin: Springer-Verlag, 1921. 23 p.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><mixed-citation>Li W., Hayashida Y., Chen Y., Tseng S. Niche regulation of corneal ephithelial steam cells at the limbis. Cell Research. 2007;17(1):26–36. doi: 10.1038/sj.er.7310137.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Goldberg M.F, Bron A.J. Limbal palisades of Vogt. Transactions of the American Ophthalmological Society. 1982; 80:155–171.</mixed-citation></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">Townsend W.M. The limbal palisades of Vogt. Transactions of the American Ophthalmological Society. 1991;89:721–756.</mixed-citation><mixed-citation xml:lang="ru">Townsend W.M. The limbal palisades of Vogt. Transactions of the American Ophthalmological Society. 1991; 89:721–756.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">Scjpal K., Bakhtiari P., Deng S. Presentation, diagnosis and management of limbal stem cell deficiency. Middle East African journal of ophthalmology. 2013;20(1):5–10. doi: 10.4103/0974-9233.106381.</mixed-citation><mixed-citation xml:lang="ru">Scjpal K., Bakhtiari P., Deng S. Presentation, diagnosis and management of limbal stem cell deficiency. Middle East African journal of ophthalmology. 2013;20(1):5–10. doi: 10.4103/ 0974-9233.106381.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><mixed-citation>Holland E.J., Schwartz G.S. The evolution of epithelial transplantation for severe ocular surface disease and a proposed classification system. Cornea. 1996;15(6):549–556.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Puangsricharern V., Tseng S.C. Cytologic evidence of corneal diseases with limbal stem cell deficiency. Ophthalmology. 1995;102(10):1476–1485. doi: 10.1016/s0161-6420(95)30842-1.</mixed-citation></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">Volkovich T.K., Samsonova I.V., Imshenetskaya T.A., Zalutsky I.V. Impression cytology: diagnostic, possibilities in ophthalmology. Rossiiskaya detskaya oftal’mologiya = Russian Ophthalmology of Children. 2016;1:46–52. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Волкович Т.К., Самсонова И.В., Имшенецкая Т.А., Залуцкий И.В. Импрессионная цитология: диагностические возможности в офтальмологии. Российская детская офтальмология. 2016;1:46–52.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><mixed-citation>Miri A., Alomar T., Nubile M. et al. In vivo confocal microscopic findings in patients with limbal stem cell deficiency. British Journal of Ophthalmology. 2012;96(4):523–529. doi: 10.1136/bjophthalmol-2011-300551.</mixed-citation></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">Optical coherence tomography in the diagnosis of eye diseases. A.G. Shchuko, V.V. Malyshev (Eds.). Мoscow, GEOTAR-Media, 2010. 128 p. (In Russ.).</mixed-citation><mixed-citation xml:lang="ru">Оптическая когерентная томография в диагностике глазных болезней. Под ред. А.Г. Щуко, В.В. Малышева. М.: ГЭОТАР-Медиа, 2010. 128 с.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><mixed-citation>Lathrop K., Gupta D., Kagemann L., Schuman J. Optical Coherence Tomography as a Rapid, Accurate, Noncontact Method of Visualizing the Palisades of Vogt. Investigative Ophthalmology &amp; Visual Science. 2012;53(3):1381–1387. doi: 10.1167/ivos.11-8524.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Patel D., Sherwin T., McGhee C. Laser scanning in vivo confocal microscopy of the normal human corneoscleral limbus. Investigative Ophthalmology &amp; Visual Science. 2006;47:2823–2827. doi:10.1167/ivos.05-1492.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Zheng T., Xu J. Age-related changes of human limbus on in vivo confocal microscopy. Cornea. 2008;27:782–786. doi:10.1097/ICO.0b013e31816f5ec3.</mixed-citation></ref></ref-list></back></article>
