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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Volgograd State Medical University</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Volgograd State Medical University</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник Волгоградского государственного медицинского университета</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1994-9480</issn><issn publication-format="electronic">1994-9499</issn><publisher><publisher-name xml:lang="en">Volgograd State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">692608</article-id><article-id pub-id-type="doi">10.19163/1994-9480-2025-22-3-179-185</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Guide for General Practitioners</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>В помощь практическому врачу</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Experience in treating epithelial ingrowth after refractive surgery. A clinical case</article-title><trans-title-group xml:lang="ru"><trans-title>Опыт лечения врастания эпителия после рефракционной хирургии. Клинический случай</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7786-5665</contrib-id><name-alternatives><name xml:lang="en"><surname>Solodkova</surname><given-names>Elena G.</given-names></name><name xml:lang="ru"><surname>Солодкова</surname><given-names>Елена Геннадиевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Volgograd Branch, Candidate of Medical Sciences, Deputy Director for Scientific Work</p></bio><bio xml:lang="ru"><p>Волгоградский филиал, кандидат медицинских наук, заместитель директора по научной работе</p></bio><email>solo23el@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fokin</surname><given-names>Viktor Р.</given-names></name><name xml:lang="ru"><surname>Фокин</surname><given-names>Виктор Петрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Volgograd Branch, Ophthalmologist</p></bio><bio xml:lang="ru"><p>Волгоградский филиал, врач-офтальмолог</p></bio><email>fokin@isee.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3694-7066</contrib-id><name-alternatives><name xml:lang="en"><surname>Breev</surname><given-names>Vladimir A.</given-names></name><name xml:lang="ru"><surname>Бреев</surname><given-names>Владимир Алексеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Volgograd Branch, Head of the Department of Correction of Refractive Errors</p></bio><bio xml:lang="ru"><p>Волгоградский филиал, заведующий отделением коррекции аномалий рефракции</p></bio><email>sleep07@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Eye Microsurgery named after Academician S.N. Fedorov</institution></aff><aff><institution xml:lang="ru">Микрохирургия глаза имени академика С.Н. Фёдорова</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-10-23" publication-format="electronic"><day>23</day><month>10</month><year>2025</year></pub-date><volume>22</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>179</fpage><lpage>185</lpage><history><date date-type="received" iso-8601-date="2025-10-09"><day>09</day><month>10</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-10-09"><day>09</day><month>10</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Solodkova E.G., Fokin V.Р., Breev V.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Солодкова Е.Г., Фокин В.П., Бреев В.А.</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Solodkova E.G., Fokin V.Р., Breev V.A.</copyright-holder><copyright-holder xml:lang="ru">Солодкова Е.Г., Фокин В.П., Бреев В.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.eco-vector.com/1994-9480/article/view/692608">https://journals.eco-vector.com/1994-9480/article/view/692608</self-uri><abstract xml:lang="en"><p>Epithelial ingrowth (EI) is a rare complication of keratorefractive surgical procedures and is characterized by the migration and proliferation of epithelial cells into the intrastromal space from the periphery to the center. Epithelial ingrowth of the cornea after keratorefractive surgery requires a comprehensive approach to diagnosis and treatment. Among modern methods, the combined use of beta therapy with electrophoresis, careful mechanical removal, and YAG laser destruction are notable. The choice of method depends on the timing of detection, localization, and degree of damage. In the presented clinical case, EI developed after LASIK surgery on both eyes, intensified, and spread to the central optical zone of the cornea in the left eye following a revision of the corneal interface. The patient underwent two courses of brachytherapy. As a result of the treatment, complete elimination of epithelial cells in the corneal interface was achieved, resulting in the formation of cloud-like opacities and sustained remission throughout the observation period (18 months).</p></abstract><trans-abstract xml:lang="ru"><p>Врастание эпителия (ВЭ) является редким осложнением кераторефракционных хирургических вмешательств и характеризуется миграцией и пролиферацией эпителиальных клеток в интрастромальное пространство от периферии к центру. Врастание эпителия роговицы после кераторефракционной операции требует комплексного подхода в диагностике и лечении. Среди современных методов выделяется комбинированное применение бета-терапии с электрофорезом, а также бережное механическое удаление и YAG-лазерная деструкция. Выбор метода зависит от срока выявления врастания, локализации и степени повреждения. В представленном клиническом случае ВЭ появилось после операции ЛАЗИК на OU, усилилось и распространилось до центральной оптической зоны роговицы на OS после ревизии роговичного интерфейса. Пациентке было проведено 2 курса брахитерапии. В результате лечения была достигнута полная элиминация эпителиальных клеток в роговичном интерфейсе с формированием облаковидного помутнения и стойкая ремиссия на протяжении всего срока наблюдения (18 мес.).</p></trans-abstract><kwd-group xml:lang="en"><kwd>epithelial ingrowth</kwd><kwd>laser in situ keratomileusis</kwd><kwd>brachytherapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>врастание эпителия</kwd><kwd>лазерный кератомилез in situ</kwd><kwd>брахитерапия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Крахмалева Д.А., Маложен С.А. Врастание эпителия после передней послойной кератопластики (клиническое наблюдение). 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