Bulletin Samara State Agricultural AcademyBulletin Samara State Agricultural Academy1997-32252782-4225Samara State Agrarian University22874Research ArticleTHE EFFECTIVENESS OF FENASAL NEW DOSAGE FORM BASED ON SUPRAMOLECULAR SYSTEMS DRUG DELIVERY AT SHEEP MONITHESDolgoshevV Apostgraduate student of the department «Bioecology and physiology of farm animals»samnivs@mail.ruFSBEI HVE SSAA150320151333511032020Copyright © 2015, Dolgoshev V.A.2015The study purpose is efficiency of new fenasal pharmaceutical formimprovement based on supramolecular nanoscale delivery systems for treatment at monitise sheep. Subjects lambs were asked niclosamide with arabinogalactan in the conduct of 1:10 (the first group) and 1:5 ( the second group) at a dose of 10 mg/kg, and basic drug niclosamide in the dosage of 100 mg/kg (the third group). The effectiveness of supramolecular complexes was similar to the efficiency of the basic drug in K ratio significance extensiveness of invasion p=0.85 and p=0.41 to compare results before and after treatment in the first and second groups, respectively. Reducing the extensiveness of invasion in the first, second and third groups was 60, 71 and 83%, respectively. The experiment showed that the supramolecular complexes were effective in 10-fold lower dose compared with the reference drug. At higher dosages up to 30 mg/kg according to the current matter, the reduction in intensity of infection after use of the drug in the first group was 74%, the second 100%. The extensiveness of invasion in the first and second groups decreased by 80% and 100%, respectively. Weighting reduce the extensiveness of invasion in the first group amounted to p=0.81, the second p=0.47, which also indicates significant differences between the results before and after treatment. According to the results of statistical processing of most similar in action with the base compound was supramolecular complex niclosamide in a dilution of 1:10. Thus, subjects doses are not interchangeable, as evidenced by the significance level of p=0.65, when comparing the results for the respective groups. The effectiveness of the supramolecular complex niclosamide with arabinogalactan in a dilution of 1:5 at the dosage of 30 mg/kg) current substance was 100% when monithes sheep at a dose of 3.3 times lower compared with the reference drug.monithesfenacalsupramolecularsystemмониезиозФенасалсупрамолекулярнаясистема[Архипов, И. А. Межвидовые отношения нематод кишечника / И. А. Архипов, E. H. Васильев // Теория и практика с паразитарными болезнями животных. - 2004. - Вып. 5. - С. 35-37.][Белова, Е. Е. Распространение аноплоцефалятозов овец в Самарской области с учетом зональных особенностей // Российский паразитологический журнал. - 2011. - №1. - С. 50-53.][Белова, Е. Е. Распространение аноплоцефалятозов овец в Самарской области при использовании пастбищ разного типа // Ветеринария Кубани. - Краснодар, 2011. - №3. - С. 21-22.][Джураев, С. Д. Эффективность монизен суспензии и гельмицид гранулята при мониезиозе овец / С. Д. Джураев, Ш. Ш. Разиков, Ф. Ф. Рахимов. - Кишоварз, 2014. - № С. 34-35.][Козлов, С. А. Антигельминтная эффективность и титрация терапевтических доз отечественного антигельминтика митранокса при мониезиозе и нематодозах овец / С. А. Козлов, М. Б. Мусаев // Российский паразитологический журнал. - 2014. - №2. - С. 81-91.][Мамедов, Э. Н. Сезонная динамика зараженности овец мониезиями // Ветеринария. - 2012. - № 1. - С. 33-34.][Толыбаева, А. Е. Антигельминтная эффективность ряда препаратов при мониезиозе овец / А. Е. Толыбаева, Р. С. Кармалиев // Ветеринария. - 2013. - №11. - С. 31-32.]