The role of human herpesvirus infections in the pathogenesis of immune-inflammatory dermatoses. Review article, part I

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Abstract

Human herpes viruses, being among the oldest pathogens, pose a significant health problem. Their unique ability to affect various organs and systems, as well as persist in the body, determines the chronic nature of the infection. Viruses most often enter through damaged skin and mucous membranes, triggering a cascade of immune responses, beginning with innate immunity in the skin and extending to other parts of the immune system as the virus replicates. the differentiated Immune response in herpes simplex virus monoinfection compared to coinfections caused by multiple herpesvirus types is of particular interest.

This review analyzes the relationship between latency and persistence of human herpes viruses and immune response characteristics in patients with inflammatory dermatoses that worsen with recurrent herpesvirus infections. Particular attention is paid to the role of herpes simplex virus types 1 and 2 in modulating immune responses and inflammatory processes. The article demonstrates that recurrences of herpesvirus infections and exacerbations of inflammatory dermatoses may be linked to common regulatory pathways of the immune response. These findings highlight the need for further research to develop new therapeutic approaches for the treatment of these interrelated pathologies.

About the authors

Evgeny Y. Evdokimov

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; Polyclinic No. 1 of the Administrative Directorate of the President of the Russian Federation

Email: elene-elene@bk.ru

Dr. Sci. (Med.), Leading Researcher, Clinical Department of Infectious Pathology, Dermatovenerologist

Russian Federation, Moscow; Moscow

Elena V. Svechnikova

Russian Biotechnology University (ROSBIOTECH); Polyclinic No. 1 of the Administrative Directorate of the President of the Russian Federation

Author for correspondence.
Email: elene-elene@bk.ru

Dr. Sci. (Med.), Professor, Department of Skin and Venereal Diseases with a Course in Cosmetology, Head of the Department of Dermatovenereology and Cosmetology

Russian Federation, Moscow; Moscow

Elvira A. Domonova

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: elene-elene@bk.ru
ORCID iD: 0000-0001-8262-3938

Dr. Sci. (Med.), Head of the Department of Dermatovenereology and Cosmetology, Laboratory of Molecular Diagnostics and Epidemiology of Opportunistic Infections, Department of Molecular Diagnostics and Epidemiology

Russian Federation, Moscow

Liana O. Ponezheva

City Polyclinic No. 180, Moscow Healthcare Department

Email: elene-elene@bk.ru
ORCID iD: 0000-0001-9459-8143

Cand. Sci. (Med.), Allergist-Immunologist

Russian Federation, Moscow

Elena V. Rzhevskaya

Polyclinic No. 1 of the Administrative Directorate of the President of the Russian Federation

Email: elene-elene@bk.ru
ORCID iD: 0000-0001-7194-8219

Cand. Sci. (Med.), Chief Physician

Russian Federation, Moscow

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