Retrospective analysis of non-hormonal treatment of stress-associated menstrual cycle disorders

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Abstract

Objective: Retrospective analysis of the efficacy and safety of Mabelle Cycle for the treatment of stress-associated menstrual cycle disorders in real-world clinical practice.

Materials and methods: A retrospective analysis of the medical records of 40 patients with stress-associated menstrual cycle disorders (according to the International Classification of Diseases, 10th Revision: N91.1 Secondary amenorrhea, N91.4 Secondary oligomenorrhea). Participants received Mabelle Cycle (active ingredients: red clover extract, vitex chasteberry fruit extract, angelica chinensis root extract, griffonia simplicifolia seed extract, D,L-phenylalanine, and iron) for 6 months, taking 2 tablets once daily. Efficacy was assessed by menstrual cycle restoration. Safety and satisfaction with the use of this herbal complex were also assessed.

Study design: A retrospective observational study using patient medical records was conducted.

Results: An improvement in a number of clinical indicators was noted while taking Mabelle Cycle. 85.0% of patients reported a normal menstrual cycle after treatment, compared with 0% before treatment (p< 0.001). At the same time, no statistically significant differences were found for a number of indicators: the frequency of amenorrhea decreased from 10.0 to 0% (p=0.125), oligomenorrhea – from 90.0 to 15.0% (p< 0.001), dysmenorrhea – from 30.0 to 5.0% (p=0.002). A decrease in the frequency of anovulation was also noted from 100.0 to 67.5% (p< 0.001). A decrease in psychoemotional manifestations was noted: the frequency of mood lability decreased from 67.5 to 7.5% (p< 0.001), tearfulness – from 10.0 to 2.5% (p=0.250), aggressiveness – from 17.5 to 5.0% (p=0.062).

Conclusion: The non-hormonal complex Mabelle Cycle is characterized by proven efficacy and safety in the correction of stress-associated menstrual cycle disorders in women of reproductive age. High patient compliance is attributable to the combination of clinical efficacy with exceptional safety, good tolerability, and ease of use.

About the authors

Tatyana M. Sokolova

Novosibirsk State Medical University

Author for correspondence.
Email: tatyana3965@mail.ru
ORCID iD: 0000-0003-3435-3536

Dr. Sci. (Med.), Professor, Department of Obstetrics and Gynecology

Russian Federation, Novosibirsk

Konstantin Y. Makarov

Novosibirsk State Medical University

Email: fdpngma@mail.ru
ORCID iD: 0000-0003-3574-6382

Dr. Sci. (Med.), Professor, Department of Obstetrics and Gynecology

Russian Federation, Novosibirsk

Tatyana V. Kiseleva

Novosibirsk State Medical University

Email: kis_tv98@mail.ru
ORCID iD: 0000-0002-4378-7945

Dr. Sci. (Med.), Professor, Department of Obstetrics and Gynecology

Russian Federation, Novosibirsk

Vitaly M. Kuleshov

Novosibirsk State Medical University

Email: kuleshov_vm@mail.ru
ORCID iD: 0000-0003-3304-1581

Dr. Sci. (Med.), Professor, Department of Obstetrics and Gynecology

Russian Federation, Novosibirsk

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