PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media277200ArticlesСтатьиCardiologic complications of acromegalyКардиологические осложнения акромегалииIlovayskayaI AИловайскаяИ А

ФГУ Эндокринологический научный центр Росмедтехнологий, Москва

IlovayskayaI AФГУ Эндокринологический научный центр Росмедтехнологий, Москва200520091610NO10 (2009)№10 (2009)253122022023Copyright ©; 2009, Bionika MediaCopyright ©; 2009, ООО «Бионика Медиа»2009Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2073-4034/article/view/277200

A frequent complication of acromegaly in any age patients is akromegalic cardiomyopathy, characterized by the formation of left ventricle myocardial hypertrophy (LVMH), and the occurrence of heart rhythm disorders. In cases with no adequate controls of hormonal disturbances in acromegaly, cardiomyopathy leads to the formation of diastolic heart failure. Surgical and pharmacological (using somatostatin analogues) treatment of acromegaly leads to the improvement of the heart condition and regress LVMH, especially in young patients (younger than 40 years) with a small duration of disease (no more than 5 years). Meaningful morpho-functional and hemodynamic parameters improvement observed in middle-aged patients.

Частым осложнением акромегалии у пациентов любого возраста является акромегалическая кардиомиопатия, для которой характерно формирование гипертрофии миокарда левого желудочка (ГМЛЖ), возникновение нарушений сердечного ритма. В случаях, когда гормональные нарушения при акромегалии остаются без адекватного контроля, кардиомиопатия приводит к формированию диастолической сердечной недостаточности. Хирургическое и медикаментозное (с помощью аналогов соматостатина) лечение акромегалии приводит к улучшению состояния сердца и регрессу ГМЛЖ, особенно у молодых пациентов (моложе 40 лет) с небольшой длительностью заболевания (не более 5 лет). Значимое улучшение морфо-функциональных и гемодинамических параметров отмечается и у пациентов среднего возраста.

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