PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media277431ArticlesСтатьиMode of bacteria-commensales interaction with immunity in certain syndromes of chronic intestinal inflammationХАРАКТЕР ВЗАИМОДЕЙСТВИЯ БАКТЕРИЙ-КОММЕНСАЛОВ С ФАКТОРАМИ ИММУНИТЕТА ПРИ НЕКОТОРЫХ СИНДРОМАХ ХРОНИЧЕСКОГО ВОСПАЛЕНИЯ КИШЕЧНИКАBekhaloV AБехалоВ А

НИИ эпидемиологии и микробиологии им. Н.Ф. Гамалеи РАМН, Москва

BondarenkoV MБондаренкоВ М

НИИ эпидемиологии и микробиологии им. Н.Ф. Гамалеи РАМН, Москва

SysolyatinaE VСысолятинаЕ В

НИИ эпидемиологии и микробиологии им. Н.Ф. Гамалеи РАМН, Москва

BechaloV ABondarenkoV MSisolyatinaE VНИИ эпидемиологии и микробиологии им. Н.Ф. Гамалеи РАМН, Москва150720091613NO13 (2009)№13 (2009)202522022023Copyright ©; 2009, Bionika MediaCopyright ©; 2009, ООО «Бионика Медиа»2009Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2073-4034/article/view/277431

This review covers the molecular mechanisms that ensure the integrity of the intestinal epithelium and the nature of the interaction of normal microflora with immunity factors in some chronic inflammatory syndromes. We highlight the role of nitric oxide in the pathogenesis of inflammatory bowel disease, and the role of transcription factor NF-kB, involved in control of expression of genes coding for the synthesis of various antimicrobial products, anti-inflammatory and anti-inflammatory cytokines, and various enzymes and other. Data presented for the molecular genetic basis of pathogenesis of inflammatory diseases of digestive tract are very important to develop more effective methods of their therapy.

В обзоре рассмотрены молекулярные механизмы, обеспечивающие целостность кишечного эпителия и характер взаимодействия нормальной микрофлоры с факторами иммунитета при некоторых синдромах хронического воспаления. Подчеркнута роль оксида азота в патогенезе воспалительных заболеваний кишечника и транскрипционного фактора NF-kB, участвующего в регуляции экспрессии генов, кодирующих синтез различных антимикробных продуктов, провоспалительных и противовоспалительных цитокинов, ряда ферментов и др. Представленные данные о молекулярно-генетических основах патогенеза воспалительных заболеваний пищеварительного тракта важны для разработки более эффективных способов их терапии.

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