PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media278013ArticlesСтатьиPhytosterins and cardiovascular diseasesФИТОСТЕРИНЫ И СЕРДЕЧНО-СОСУДИСТЫЕ ЗАБОЛЕВАНИЯPerovaN VПероваН В

ФГУ Государственный научно-исследовательский центр профилактической медицины Росмедтехнологии, Москва

PerovaN VФГУ Государственный научно-исследовательский центр профилактической медицины Росмедтехнологии, Москва150820091615NO15 (2009)№15 (2009)151923022023Copyright ©; 2009, Bionika MediaCopyright ©; 2009, ООО «Бионика Медиа»2009Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2073-4034/article/view/278013

It has been proved that the consumption of phytosterins in doses of 1.5-3.0 g daily in the "functional" foods leads to a decrease of plasma total cholesterol and low density lipoprotein by 10-15%. These data determine the interest of researchers to the role of phytosterins in the prevention of cardiovascular disease (CVD) and their acute complications. In this regard, there are some conflicting data obtained in studies on animal and human associated with dose-related effects of phytosterins and various accuracy and selectivity measurement techniques. In LASA (2008) epidemiological study, included random sample of 1,242 people older than 65 year in the Netherlands showed that moderate increase of plasma phytosterol levels was associated with reduction of risk for cardiovascular disease. Prospective randomized placebo-controlled clinical studies with fixed endpoints are required to confirm the effectiveness of phytosterol in the "functional" foods for the prevention of CVD and their acute complications at the level of evidence-based medicine.

Доказано, что потребление растительных стеринов в дозах 1,5-3,0 г в сутки в составе функциональных пищевых продуктов приводит к снижению в плазме крови уровня общего холестерина и липопротеидов низкой плотности на 10-15 %. Эти данные обусловливают интерес исследователей к роли фитостеринов в профилактике развития сердечно-сосудистых заболеваний (ССЗ) и их острых осложнений. В этом отношении имеется ряд противоречащих друг другу данных, полученных в экспериментах на животных и в исследованиях с участием людей, связанных с дозозависимыми эффектами фитостеринов и применением методов их измерения, обладающих разной точностью и селективностью. В эпидемиологическом исследовании LASA (2008), проведенном в Нидерландах на случайной выборке из 1242 человек старше 65 лет, было доказано, что умеренно повышенный уровень фитостеринов в плазме крови ассоциирован со сниженным риском ССЗ. Проспективные рандомизированные плацебо-контролируемые клинические исследования с фиксированными конечными точками окончательно могут на уровне доказательной медицины подтвердить эффективность использования фитостеринов в составе функциональных продуктов для профилактики развития ССЗ и их острых осложнений.

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