PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media278032ArticlesСтатьиInsulin resistance and heart diseases: is there a relationship?ИНСУЛИНОРЕЗИСТЕНТНОСТЬ И БОЛЕЗНИ СЕРДЦА: ЕСТЬ ЛИ СВЯЗЬ?DrapkinaO MДрапкинаО М

Клиника пропедевтики внутренних болезней ММА им. И.М. Сеченова, Москва

SmirinV IСмиринВ И

Клиника пропедевтики внутренних болезней ММА им. И.М. Сеченова, Москва

IvashkinV TИвашкинВ Т

Клиника пропедевтики внутренних болезней ММА им. И.М. Сеченова, Москва

DrapkinaO MSmirinV IIvaschkinV TКлиника пропедевтики внутренних болезней ММА им. И.М. Сеченова, Москва150820091615NO15 (2009)№15 (2009)616523022023Copyright ©; 2009, Bionika MediaCopyright ©; 2009, ООО «Бионика Медиа»2009Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2073-4034/article/view/278032

We consider the nature of insulin resistance (IR) underlying on development of type 2 diabetes mellitus and metabolic syndrome, and the main cellular and molecular mechanisms of its formation are presented. The paper is dedicated to the pathogenetic link between IR and hypertension, IR importance in the development of diabetic cardiomyopathy. It is emphasized that metformin (Siofor) is the best drug for insulin sensitivity restoration and improvement of prognosis in cardiac patients. The presence of a various cardioprotective effects of metformin facilitates therapy optimization for patients with high risk of cardiovascular disease.

Рассматривается природа инсулинорезистентности (ИР), лежащей в основе развития сахарного диабета типа 2 и метаболического синдрома, представлены основные клеточно-молекулярные механизмы ее формирования. Указывается на патогенетическую связь между ИР и артериальной гипертензией, обсуждается значение ИР в развитии диабетической кардиомиопатии. Подчеркивается, что оптимальным препаратом, восстанавливающим чувствительность к инсулину и улучшающим прогноз у кардиологических больных, является метформин (Сиофор). Наличие у метформина разнообразных кардиопротективных эффектов способствует оптимизации терапии больных с высоким риском сердечно-сосудистых заболеваний.

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