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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pharmateca</journal-id><journal-title-group><journal-title xml:lang="en">Pharmateca</journal-title><trans-title-group xml:lang="ru"><trans-title>Фарматека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2073-4034</issn><issn publication-format="electronic">2414-9128</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">278425</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">PECULIARITIES OF THE DIAGNOSIS AND TREATMENT OF INFERTILITY IN MEN WITH OBESITY</article-title><trans-title-group xml:lang="ru"><trans-title>Особенности диагностики и лечения бесплодия у мужчин с ожирением</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name><surname>Hamidov</surname><given-names>S</given-names></name><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Ovchinnikov</surname><given-names>R</given-names></name><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Popova</surname><given-names>A</given-names></name><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Viryasov</surname><given-names>A</given-names></name><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Myasnikov</surname><given-names>D</given-names></name><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Tazhetdinov</surname><given-names>O</given-names></name><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gamidov</surname><given-names>Safail ogly</given-names></name><name xml:lang="ru"><surname>Гамидов</surname><given-names>Сафаил оглы</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра урологии ГОУ ВПО РГМУ, МоскваКафедра акушерства, гинекологии, перинатологии и репродуктологии с курсом клинической андрологии ГОУ ВПО ММА им. И.М. Сеченова, Москва</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ovchinnikov</surname><given-names>Ruslan Igorevich</given-names></name><name xml:lang="ru"><surname>Овчинников</surname><given-names>Руслан Игоревич</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра урологии ГОУ ВПО РГМУ, Москва</p></bio><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Popova</surname><given-names>Alina Yur'evna</given-names></name><name xml:lang="ru"><surname>Попова</surname><given-names>Алина Юрьевна</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра акушерства, гинекологии, перинатологии и репродуктологии с курсом клинической андрологии ГОУ ВПО ММА им. И.М. Сеченова, Москва</p></bio><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Viryasov</surname><given-names>Andrey Vasil'evich</given-names></name><name xml:lang="ru"><surname>Вирясов</surname><given-names>Андрей Васильевич</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра урологии ГОУ ВПО РГМУ, Москва</p></bio><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Myasnikov</surname><given-names>Dmitriy Anatol'evich</given-names></name><name xml:lang="ru"><surname>Мясников</surname><given-names>Дмитрий Анатольевич</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра урологии ГОУ ВПО РГМУ, Москва</p></bio><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tazhetdinov</surname><given-names>Oleg Khalitovich</given-names></name><name xml:lang="ru"><surname>Тажетдинов</surname><given-names>Олег Халитович</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра урологии ГОУ ВПО РГМУ, Москва</p></bio><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff id="aff1"><institution></institution></aff><aff-alternatives id="aff2"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Кафедра урологии ГОУ ВПО РГМУ, МоскваКафедра акушерства, гинекологии, перинатологии и репродуктологии с курсом клинической андрологии ГОУ ВПО ММА им. И.М. Сеченова, Москва</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Кафедра урологии ГОУ ВПО РГМУ, Москва</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Кафедра акушерства, гинекологии, перинатологии и репродуктологии с курсом клинической андрологии ГОУ ВПО ММА им. И.М. Сеченова, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2010-05-15" publication-format="electronic"><day>15</day><month>05</month><year>2010</year></pub-date><volume>17</volume><issue>9</issue><issue-title xml:lang="en">NO9 (2010)</issue-title><issue-title xml:lang="ru">№9 (2010)</issue-title><fpage>18</fpage><lpage>23</lpage><history><date date-type="received" iso-8601-date="2023-02-23"><day>23</day><month>02</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2010, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2010, ООО «Бионика Медиа»</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2073-4034/article/view/278425">https://journals.eco-vector.com/2073-4034/article/view/278425</self-uri><abstract xml:lang="en"><p>There are more than 17% of infertile couples in Russia, and this figure tends to increase. About half of cases of infertility are caused by male infertility. Infertility is idiopathic in 31 to 75% of men. These patients are mainly empirically treated using drugs of different groups (antiestrogen, aromatase inhibitors, luteinizing hormone, follicle-stimulating hormone, gonadotropin-releasing hormone, antioxidants and biologically active dietary supplements, etc.) that are frequently ineffective. As possible, obesity is one of the factors that adversely affect sperm parameters. According to the WHO data (2003), 1.7 billion people worldwide are overweight, a significant portion of them are men of reproductive age. This article discusses the main ways of pathogenesis, diagnosis and treatment of infertility in men with obesity.</p></abstract><trans-abstract xml:lang="ru"><p>В России бесплодные пары составляют более 17 %, и эта цифра имеет тенденцию к росту. Около половины случаев бесплодия пары обусловлено бесплодием мужчины. У 31-75 % мужчин бесплодие является идиопатическим. Лечение этих пациентов осуществляется главным образом эмпирически, применяются лекарственные средства различных групп (антиэстрогены, ингибиторы ароматазы, лютеинизирующий гормон, фолликулостимулирующий гормон, гонадотропин-рилизинг гормон, антиоксиданты, биологически активные добавки к пище и др.), которые часто оказываются неэффективными. Одним из возможных факторов, отрицательно влияющих на показатели спермограммы, может являться ожирение. По данным ВОP (2003), 1,7 млрд человек в мире имеют избыточную массу тела, значительную часть из них составляют мужчины репродуктивного возраста. В данной статье рассматриваются основные возможные пути патогенеза, диагностики и лечения бесплодия у мужчин с ожирением.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Key words:</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>ожирение</kwd><kwd>мужское бесплодие</kwd><kwd>лечение</kwd><kwd>диагностика</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>WHO manual for the standardized investigation and diagnosis of the infertile couple. WHO, 3-th ed. Cambridge universiti press 2000;90.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Сухих Г.Т., Божедомов В.А. Мужское бесплодие. М., 2009. C. 7.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Нишлаг Э., Бере Г.М. Андрология. М., 2005. C. 102.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>WHO manual for the standardized investigation and diagnosis of the infertile couple. WHO, 3-th ed. Cambridge universiti press, 2000;105.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Демидова Т.Ю., Аметов А.С., Пархонина Е.С. Ожирение - основа метаболического синдрома // Лечащий врач. 2002. № 5. С. 28-31.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Abdel-Halim R.E. Obesity: 1000 years ago. Lancet 2005;366:204.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Avicenna. The disadvantages of excessive weight. In: Avicenna. The canon of medicine, book IV: diseases involving more than one member; the Cosmetic art. Medical Press. 1593:173-74.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Hedley AA, Ogden CL, Johnson CL, et al. Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002. JAMA 2004;291:2847-50.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Magnusdottir EV, Thorsteinsson T, Thorsteinsdottir S, et al. Persistent organochlorines, sedentary occupation, obesity and human male subfertility. Hum Reprod 2005;20:208-15.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Sallmen M, Sandler DP, Hoppin JA, et al. Reduced fertility among overweight and obese men. Epidemiology 2006;17:520-23.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Alavanja MC, Sandler DP, McMaster SB, et al. The Agricultural Health Study. Environ Health Perspect 1996;104:362-9.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Ramlau-Hansen CH, Thulstrup AM, Nohr EA, et al. Subfecundity in overweight and obese couples. Hum Reprod 2007;22:1634-37.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Olsen J, Melbye M, Olsen SF, et al. The Danish National Birth Cohort-its background, structure and aim. Scand J Public Health 2001;29:300-07.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Nguyen R, Wilcox A, Skjaerven R, et al. Men's body mass index and infertility. Hum Reprod 2007;17:2488-93.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Hanafy S, Halawa FA, Mostafa T, et al. Serum leptin correlates in infertile oligozoospermic males. Andrologia 2007;39:177-80.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Zorn B, Osredkar J, Meden-Vrtovec H, et al. Leptin levels in infertile male patients are correlated with inhibin B, testosterone and SHBG but not with sperm characteristics. Int J Androl 2007;30(5),439-44.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Bonde JP, Ernst E, Jensen TK, et al. Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners. Lancet 1998;352:1172-77.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Guzick DS, Overstreet JW, Factor-Litvak P, et al. Sperm morphology, motility, and concentration in fertile and infertile men. N Engl J Med 2001;345:1388-93.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Slama R, Eustache F, Ducot B, et al. Time to pregnancy and semen parameters: a cross-sectional study among fertile couples from four European cities. Hum Reprod 2002;17:503-15.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Jensen TK, Andersson AM, Jorgensen N, et al. Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril 2004;82:863-70.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Fejes I, Koloszar S, Szollosi J, et al. Is semen quality affected by male body fat distribution? Andrologia 2005;37:155-59.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Kort HI, Massey JB, ElsnerCW, et al. Impact of body mass index values on sperm quantity and quality. J Androl 2006;27:450-52.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Giagulli VA, Kaufman JM, Vermeulen A. Pathogenesis of the decreased androgen levels in obese men. J Clin Endocrinol Metab 1994;79:997-1000.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Tchernof A, Despres JP, Belanger A, et al. Reduced testosterone and adrenal C19 steroid levels in obese men. Metabolism 1995;44:513-19.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Schneider G, Kirschner MA, Berkowitz R, et al. Increased estrogen production in obese men. J Clin Endocrinol Metab 1979;48:633-38.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Akingbemi BT. Estrogen regulation of testicular function. Reprod Biol Endocrinol 2005;3:51.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Cohen PG. The hypogonadal-obesity cycle: role of aromatase in modulating the testosterone-estradiol shunt - a major factor in the genesis of morbid obesity. Med Hypotheses 1999;52(1):49-51.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Marin P, Oden B, Bjorntorp P. Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: effects of androgens. J Clin Endocrinol Metab 1995;80:239-43.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Kapoor D, Channer KS, Jones TH. Rosiglitazone increases bioactive testosterone and reduces waist circumference in hypogonadal men with Type 2 diabetes. Diabetes Vasc Dis Res 2008;5(2):135-37.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Kaukua J, Pekkarinen T, Sane T, et al. Sex hormones and sexual function in obese men losing weight. Obes Res 2003;11:689-94.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Price TM, O'Brien SN, Welter BH, et al. Oestrogen regulation of adipose tissue lipoprotein lipase-possible mechanisms of body fat distribution. Am J Obstet Gynecol 1998;178:101-07.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>de Boer H, Verschoor L, Ruinemans-Koerts J, et al. Letrozole normalizes serum testosterone in severely obese men with hypogonadotropic hypogonadism. Diabetes Obes Metab 2005;7:211-15.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Pavlovich CP, King P, Goldstein M, et al. Evidence of a treatable endocrinopathy in infertile men. J Urol 2001;165:837-41.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Tsai EC, Matsumoto AM, Fujimoto WY, et al. Association of bioavailable, free, and total testosterone with insulin resistance: influence of sex hormone-binding globulin and body fat. Diabetes Care 2004;27:861-8.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Luboshitzky R, Lavie L, Shen-Orr Z, et al. Altered luteinizing hormone and testosterone secretion in middle-aged obese men with obstructive sleep apnea. Obes Res 2005;13:780-86.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Luboshitzky R, Zabari Z, Shen-Orr Z, et al. Disruption of the nocturnal testosterone rhythm by sleep fragmentation in normal men. J Clin Endocrinol Metab 2001;86:1134-39.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Blank DM, Clark RV, Heymsfield SB, et al. Endogenous opioids and hypogonadism in human obesity. Brain Res Bull 1994;34:571-74.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Baccetti B, La Marca A, Piomboni P, et al. Insulin-dependent diabetes in men is associated with hypothalamo-pituitary derangement and with impairment in semen quality. Hum Reprod 2002;17:2673-77.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Agbaje IM, Rogers DA, McVicar CM, et al. Insulin dependant diabetes mellitus: implications for male reproductive function. Hum Reprod 2007;22:1871-77.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Margetic S, Gazzola C, Pegg GG, et al. Leptin: a review of its peripheral actions and interactions. Int J Obes Relat Metab Disord 2002;26:1407-33.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Isidori A, Fabbri A. Leptin and androgens in male obesity: evidence for leptin contribution to reduced androgen levels. J Clin Endocrinol Metab 1999;84:3673-80.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Vettor R, De Pergola G, Pagano C, et al. Gender differences in serum leptin in obese people: relationships with testosterone, body fat distribution and insulin sensitivity. Eur J Clin Invest 1997;27:1016-24.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Zorn B, Osredkar J, Meden-Vrtovec H, et al. Leptin levels in infertile male patients are correlated with inhibin B, testosterone and SHBG but not with sperm characteristics. Int J Androl 2007;30(5):439-44.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Hanafy S, Halawa FA, Mostafa T, et al. Serum leptin correlates in infertile oligozoospermic males. Andrologia 2007;39:177-80.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Ozata M, Ozdemir IC, Licinio J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab 1999;84(10):3686-95.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Strobel A, Issad T, Camoin L, et al. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet 1998;18:213-15.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Oliva A, Spira A, Multigner L. Contribution of environmental factors to the risk of male infertility. Hum Reprod 2001;16:1768-76.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Sharpe RM. Lifestyle and environmental contribution to male infertility. Br Med Bull 2000;56:630-42.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Jung A, Schill WB. Male infertility. Current life style could be responsible for infertility. MMW Fortschr Med 2000;142:31-3.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Munoz-de-Toro M, Beldomenico HR, Garcia SR, et al. Organochlorine levels in adipose tissue of women from a littoral region of Argentina. Environ Res 2006;102:107-12.</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Marin P, Oden B, Bjorntorp P. Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: effects of androgens. J Clin Endocrinol Metab 1995;80:239-43.</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Mieusset R, Bujan LE, Massat G, et al. Inconstant ascending testis as a potential risk factor for spermatogenesis in infertile men with no history of cryptorchism. Hum Reprod 1997;12:974-79.</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Bujan L, Daudin M, Charlet JP, et al. Increase in scrotal temperature in car drivers. Hum Reprod 2000;15:1355-57.</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Figa-Talamanca I, Cini C, Varricchio GC, et al. Effects of prolonged autovehicle driving on male reproduction function: a study among taxi drivers. Am J Ind Med 1996;30:750-58.</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Brindley GS. Deep scrotal temperature and the effect on it of clothing, air temperature, activity, posture and paraplegia. Br J Urol 1982;54:49-55.</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Momen MN, Fahmy I, Amer M, et al. Semen parameters in men with spinal cord injury: changes and aetiology. Asian J Androl 2007;9:684-89.</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>Shafik A, Olfat S. Lipectomy in the treatment of scrotal lipomatosis. Br J Urol 1981;53:55-61.</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>Jung A, Schill WB. Male infertility. Current life style could be responsible for infertility. MMW Fortschr Med 2000;142:31-3.</mixed-citation></ref><ref id="B59"><label>59.</label><mixed-citation>Bacon CG, Mittleman MA, Kawachi I, et al. Sexual function in men older than 50 years of age: results from the health professionals follow-up study. Ann Intern Med 2003;139:161-68.</mixed-citation></ref><ref id="B60"><label>60.</label><mixed-citation>Feldman HA, Johannes CB, Derby CA, et al. Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts Male Aging Study. Prev Med 2000;30:328-38.</mixed-citation></ref><ref id="B61"><label>61.</label><mixed-citation>O'Brien JH, Lazarou S, Deane L, et al. Erectile dysfunction and andropause symptoms in infertile men. J Urol 2005;174:1932-34.</mixed-citation></ref><ref id="B62"><label>62.</label><mixed-citation>Seftel A. Male hypogonadism. Part II: etiology, pathophysiology, and diagnosis. Int J Impot Res 2006;18:223-28.</mixed-citation></ref><ref id="B63"><label>63.</label><mixed-citation>Sullivan ME, Thompson CS, Dashwood MR, et al. Nitric oxide and penile erection: is erectile dysfunction another manifestation of vascular disease? Cardiovasc Res 1999;43:658-65.</mixed-citation></ref><ref id="B64"><label>64.</label><mixed-citation>Chung WS, Sohn JH, Park YY. Is obesity an underlying factor in erectile dysfunction? Eur Urol 1999;36:68-70.</mixed-citation></ref><ref id="B65"><label>65.</label><mixed-citation>Feldman HA, Johannes CB, Derby CA, et al. Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts Male Aging Study. Prev Med 2000;30:328-38.</mixed-citation></ref><ref id="B66"><label>66.</label><mixed-citation>Brody S. Slimness is associated with greater intercourse and lesser masturbation frequency. J Sex Marital Ther 2004;30:251-61.</mixed-citation></ref><ref id="B67"><label>67.</label><mixed-citation>Kaukua J, Pekkarinen T, Sane T, et al. Sex hormones and sexual function in obese men losing weight. Obes Res 2003;11:689-94.</mixed-citation></ref><ref id="B68"><label>68.</label><mixed-citation>Niskanen L, Laaksonen DE, Punnonen K, et al. Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome. Diabetes Obes Metab 2004;6:208-15.</mixed-citation></ref><ref id="B69"><label>69.</label><mixed-citation>Globerman H, Shen-Orr Z, Karnieli E, et al. Inhibin B in men with severe obesity and after weight reduction following gastroplasty. Endocr Res 2005;31:17.</mixed-citation></ref><ref id="B70"><label>70.</label><mixed-citation>Bastounis EA, Karayiannakis AJ, Syrigos K, et al. Sex hormone changes in morbidly obese patients after vertical banded gastroplasty. Eur Surg Res 1998;30:43-7.</mixed-citation></ref><ref id="B71"><label>71.</label><mixed-citation>Bacon CG, Mittleman MA, Kawachi I, et al. Sexual function in men older than 50 years of age: results from the health professionals follow-up study. Ann Intern Med 2003;139:161-68.</mixed-citation></ref><ref id="B72"><label>72.</label><mixed-citation>Esposito K, Giugliano F, Di Palo C, et al. Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial. JAMA 2004;291:2978-84.</mixed-citation></ref><ref id="B73"><label>73.</label><mixed-citation>Semple PA, Graham A, Malcolm Y, et al. Hypoxia, depression of testosterone, and impotence in pickwickian syndrome reversed by weight reduction. Br Med J (Clin Res Ed) 1984;289:801-02.</mixed-citation></ref><ref id="B74"><label>74.</label><mixed-citation>Clark RV, Sherins RJ. Treatment of men with idiopathic oligozoospermic infertility using the aromatase inhibitor, testolactone. Results of a double-blinded, randomized, placebo-controlled trial with crossover. J Androl 1989;10:240-47.</mixed-citation></ref><ref id="B75"><label>75.</label><mixed-citation>Vandekerckhove P, O'Donovan PA, Lilford RJ, et al. Infertility treatment: from cookery to science. The epidemiology of randomised controlled trials. Br J Obstet Gynaecol 1993;100:1005-36.</mixed-citation></ref></ref-list></back></article>
