PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media278634ArticlesСтатьиTERAPEVTIChESKIE VOZMOZhNOSTI BENFOTIAMINAТЕРАПЕВТИЧЕСКИЕ ВОЗМОЖНОСТИ БЕНФОТИАМИНАGur'evaIrina VladimirovnaГурьеваИрина Владимировна

Российская медицинская академия последипломного образования, Федеральное бюро медико-социальной экспертизы, Москва

Российская медицинская академия последипломного образования, Федеральное бюро медико-социальной экспертизы, Москва200820101716NO16 (2010)№16 (2010)263023022023Copyright ©; 2010, Bionika MediaCopyright ©; 2010, ООО «Бионика Медиа»2010Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2073-4034/article/view/278634

Diabetes mellitus (DM) remains one of the most serious chronic diseases that lead to disabling complications. Pilot clinical studies have actively studied thiaminpyrophosphate (thiamine and benfotiamine) for the prevention of complications of diabetes. The results of 4 randomized, blind clinical studies have confirmed the efficacy of benfotiamine in the treatment of diabetic polyneuropathy. A number of experimental studies have shown prospects of benfotiamine for the treatment of diabetic nephropathy, retinopathy, and cardiomyopathy in DM. Thus, the benfotiamine has multiphasic effects in the treatment of DM, and opens new possibilities for pathogenetic treatment of vascular complications.

Сахарный диабет (СД) остается одним из наиболее серьезных хронических заболеваний, приводящих к инвалидизирующим осложнениям. Тиаминпирофосфат (тиамин и бенфотиамин) является субстанцией, активно изучаемой в экспериментальных клинических исследованиях с целью предотвращения осложнений СД. Получены результаты четырех слепых клинических рандомизированных исследований, подтверждающие эффективность воздействия бенфотиамина на проявления диабетической полинейропатии. Проведен ряд исследований, в основном экспериментального характера, показавших перспективы применения бенфотиамина для лечения диабетической нефропатии, ретинопатии, кардиомиопатии при СД. Таким образом, применение бенфотиамина оказывает многопрофильное действие при лечении лиц, страдающих СД, что открывает новые возможности патогенетического лечения его сосудистых осложнений.

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