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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pharmateca</journal-id><journal-title-group><journal-title xml:lang="en">Pharmateca</journal-title><trans-title-group xml:lang="ru"><trans-title>Фарматека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2073-4034</issn><issn publication-format="electronic">2414-9128</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">278701</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">SYSTEMIC ATHEROSCLEROSIS IN THERAPEUTIC PRACTICE: TOWARDS THE OPTIMIZATION OF MANAGEMENT</article-title><trans-title-group xml:lang="ru"><trans-title>РАСПРОСТРАНЕННЫЙ АТЕРОСКЛЕРОЗ В ОБЩЕТЕРАПЕВТИЧЕСКОЙ ПРАКТИКЕ: НА ПУТИ К ОПТИМИЗАЦИИ ТАКТИКИ ВЕДЕНИЯ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name><surname>Fomin</surname><given-names>V V</given-names></name><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fomin</surname><given-names>Viktor Viktorovich</given-names></name><name xml:lang="ru"><surname>Фомин</surname><given-names>Виктор Викторович</given-names></name></name-alternatives><bio xml:lang="ru"><p>ГОУ ВПО Первый МГМУ им. И.М. Сеченова Минздравсоцразвития России, Москва</p></bio><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff id="aff1"><institution></institution></aff><aff-alternatives id="aff2"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ГОУ ВПО Первый МГМУ им. И.М. Сеченова Минздравсоцразвития России, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2010-09-20" publication-format="electronic"><day>20</day><month>09</month><year>2010</year></pub-date><volume>17</volume><issue>18-19</issue><issue-title xml:lang="en">NO18-19 (2010)</issue-title><issue-title xml:lang="ru">№18-19 (2010)</issue-title><fpage>27</fpage><lpage>31</lpage><history><date date-type="received" iso-8601-date="2023-02-23"><day>23</day><month>02</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2010, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2010, ООО «Бионика Медиа»</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2073-4034/article/view/278701">https://journals.eco-vector.com/2073-4034/article/view/278701</self-uri><abstract xml:lang="en"><p>The article discusses modern approaches to early detection of preclinical markers of systemic atherosclerosis and management of these patients. It is emphasized that the currently available instrumental methods of early preclinical diagnosis of atherosclerosis of major vascular territories are particularly important in terms of timely optimizing of therapeutic strategy. Maximum use of treatment modalities includes administration of ACE inhibitors and pentoxifylline in these patients</p></abstract><trans-abstract xml:lang="ru"><p>Обсуждаются современные подходы к раннему выявлению доклинических маркеров распространенного атеросклероза и ведению этой категории больных. Подчеркивается, что доступные сегодня инструментальные методы ранней доклинической диагностики атеросклеротического поражения основных сосудистых бассейнов приобретают особое значение с точки зрения своевременной оптимизации терапевтической стратегии. Максимальное использование возможностей лечения подразумевает в т. ч. применение у этих больных ингибиторов АПФ и пентоксифиллина.</p></trans-abstract><kwd-group xml:lang="en"><kwd>atherosclerosis</kwd><kwd>carotid arteries</kwd><kwd>intermittent clauscidation</kwd><kwd>pentoxiphylline</kwd><kwd>ACE inhibitors</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>атеросклероз</kwd><kwd>сонные артерии</kwd><kwd>синдром перемежающейся хромоты</kwd><kwd>пентоксифиллин</kwd><kwd>ингибиторы АПФ</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Диагностика и лечение артериальной гипертензии. Рекомендации Российского медицинского общества по артериальной гипертонии и Всероссийского научного общества кардиологов // Системные гипертензии. 2010. № 3. С. 5-26.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Hodis HN, Mack WJ, LaBree L, et al. 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