PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media278810ArticlesСтатьиOBSTRUCTIVE SLEEP APNEA AND ASSOCIATED CARDIOVASCULAR COMPLICATIONSСИНДРОМ ОБСТРУКТИВНОГО АПНОЭ ВО ВРЕМЯ СНАИ СВЯЗАННЫЕ С НИМ СЕРДЕЧНО-СОСУДИСТЫЕ ОСЛОЖНЕНИЯLitvinAleksandr Yur'evichЛитвинАлександр Юрьевич

ФГУ Российский кардиологический научно-производственный комплекс Росмедтехнологий, Институт клинической кардиологии им. А. Л. Мясникова

LitvinA YuФГУ Российский кардиологический научно-производственный комплекс Росмедтехнологий, Институт клинической кардиологии им. А. Л. Мясникова20022011184NO4 (2011)№4 (2011)293423022023Copyright ©; 2011, Bionika MediaCopyright ©; 2011, ООО «Бионика Медиа»2011Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2073-4034/article/view/278810

The article discusses the problem of obstructive sleep apnea (OSA). Data for the pathogenesis, risk factors, diagnosis, clinical manifestations and treatment of this syndrome are presented. The association of OSA with cardiovascular diseases such as hypertension, stroke, and atherosclerosis is demonstrated.

Обсуждается проблема синдрома обструктивного апноэ сна (СОАС). Представлены данные по патогенезу, факторам риска, диагностике, клинике и методам лечения данного синдрома. Показана связь СОАС с развитием сердечно-сосудистых заболеваний, таких как артериальная гипертензия, нарушение мозгового кровообращения, атеросклероз.

obstructive sleep apnoeacardiovascular diseasesupper respiratory tractCPAP-therapyсиндром апноэ во время сназаболевания сердечно-сосудистой системыверхние дыхательные путиCPAP-терапияMann GCV. Obstructive sleep apnea. Diagnosis and treatment. Med Clin North Am 1996; 80:803-20.Deegan PC, McNicholas WT. Pathophysiology of obstructive sleep apnoea. Eur Respir J 1995;8:1161-78.Johns MV. Daytime sleepiness, snoring, and obstructive sleep apnea. The Epworth Sleeping Scale. Chest 1993;103:30-6.White DP. Pathophysiology of obstructive sleep apnea. Thorax 1995;50:797-804.Лопатин, А.С., Бузунов Р.В., Смушко А. М. и соавт. Храп и синдром обструктивного апноэ во сне. Российская ринология. 1998. № 4. С. 17-32.Houvelingen van KG, van Uffeln R, van Villet ACM. Sleep apnea syndrome (Review). Eur Heart J 1999;20:858-66.Phillipson EA. Wake up, America. A Report of the National Commission on Sleep Disorders Research, 1993.Strohl KP, Redline S. State of the art: recognition of obstructive sleep apnea. Am J Respir Crit Care Med 1996;154:279-89.Guilleminault C, Tilkian A, Dement WC. The sleep apnea syndromes. An Rev Med 1976; 11:399-402.Cirignotta F, D'Alessandro R, Partinen M, et al. Prevalence of every night snoring and obstructive sleep apneas among 30-69 years old men in Bologna, Italy. Acta Psychiatr Scand 1989;79:366-72.Hoffstein V. Blood pressure, snoring, obesity, and nocturnal hypoxaemia. Lancet 1994; 344:643-5.Вейн АМ. Медицина сна (лекция). Кремлевская медицина. Клинический вестник 1998; 5 (дополнит. номер): 70-72.Guilleminault C, Partinen M, Hollman K, et al. Familial aggregates in obstructive sleep apnea syndrome. Chest 1995; 107: 1545-51.Redline S, Tishler PV, Tosteson TD, et al. The familial aggregation of obstructive sleep apnea. Am J Respir Crit Care Med 1995; 151: 682-7.Bonsignore NR, Marrone O, Insalaco G, Bonsignore G. The cardiovascular effects of obstructive sleep apneas: analysis of pathogenic mechansms. Eur Respir J 1994; 7: 786-805.Shepard Jr JV. Hypertension, cardiac arrhythmias, myocardial infarction and stroke in relation to obstructive sleep apnea. Clinics in Chest Med 1992; 13:437-56.Peter JH, Koehler U, Grote L, Podszus T. Manifestation and consequences of obstructive sleep apnoea. Eur Respir J 1995; 8:1572-83.Strollo RJ, Rogers RM. Current concepts: obstructive sleep apnea. New Engl J Med 1996; 334:99-104.Kraiczi H, Hedner J, Peker Y, Grote L. Comparison of atenolol, amlodipine, enalapril, hydrochlorothiazide, and losartan for antihypertensive treatment in patients with obstructive sleep apnea. Am J Respir Crit Care Med 2000; 161(5):1423-8.Longstaff M. Mechanisms proposed whereby beta-blockers might worsen obstructive sleep apnoea. Respir Med 1999; 93(4):290.Fletcher EC. Effect of episodic hypoxia on sympathetic activity and blood pressure. Respir Physiol 2000; 119(2-3): 189-97.Garpestad E, Ringler J, Parker A, and al. Sleep stage influences the hemodynamic response to obstructive apnea. Am J Respir Crit Care Med 1995; 152:199-203.Eisensehr I, Ehrenberg BL, Noachtar S, et al. Platelet activation, epinephrine, and blood pressure in obstructive sleep apnea syndrome. Neurology. 1998 Jul; 51(1):188-95.Kohler U, et al. Herzrhythmusstorungen bei Schlafapnoe. Erhohtes kardiovaskulares Risk durch nachtliche Arrhythmien? Fortschr Med. 1998 Jun 10; 116(16): 28-31.Friedlander AH, Friedlander IK, Yueh R, Littner MR. The prevalence of carotid atheromas seen on panoramic radiographs of patients with obstructive sleep apnea and their relation to risk factors for atherosclerosis. J Oral Maxillofac Surg 1999 May; 57(5):516-21; discussion 521-22.Netzer N, Werner P, Jochums I, Lehmann M, Strohl KP. Blood flow of the middle cerebral artery with sleep-disordered breathing: correlation with obstructive hypopneas. Stroke 1998; 29(1):87-93.Wessendorf TE, Teschler H, Wang YM, Konietzko N, Thilmann AF. Sleep-disordered breathing among patients with first-ever stroke. J Neurol 2000; 247(1):41-7.Ammon PK. TI: Individualizing the approach to treating obesity. Nurse Pract 1999; Feb; 24(2):27-31, 36-8, 41; quiz 42-3.Placidi F, Diomedi M, Cupini LM, Bernardi G, Silvestrini M. Impairment of daytime cerebrovascular reactivity in patients with obstructive sleep apnoea syndrome. J Sleep Res 1998; 7(4):288-92.Peker Y, Kraiczi H, Hedner J et al. An independent association between obstructive sleep apnoea and coronary artery disease. Eur Respir J 1999; 14(1):179-84.Wright J, Johnes R, Walt E, et al. Health effects of obstructive sleep apnoea and the effectiveness of continuous positive airway pressure: a systematic review of the researched evidence. Br Med J 1997;314: 851-60.Sullivan CE, Issa FG, Berton-Johnes M, Eves L. Reversal of obstructive sleep apnoea by continuous positive airway pressure therapy. Lancet 1981; i:862-65.Quan S.F., Gersh B.J. Cardiovascular consequences of sleep-disordered breathing: past, present and future. Report of a Workshop from the National Center on Sleep Disorders Research and the National Heart, Lung, and Blood Institute. Circulation 2004; 109:951-57.White J, Cates C, Wright J. Continuous positive airways pressure for obstructive sleep apnoea (Cochrane Review). In: The Cochrane Library, Issue 1, 2004. Chichester, UK: John Wiley & S.McKinney M. Speeding up heartbeat may improve sleep apnea. New Engl J Med 2002;346:390, 404-12, 444. (Review).