PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media278853ArticlesСтатьиINDIVIDUALIZATION OF ADJUVANT THERAPY OF BREAST CANCERИНДИВИДУАЛИЗАЦИЯ АДЪЮВАНТНОЙ ТЕРАПИИ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫSemiglazovVladimir FedorovichСемиглазовВладимир Федорович

ФГУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития России

SemiglazovVladislav VladimirovichСемиглазовВладислав Владимирович

СПГМУ им. академика И.П. Павлова

PaltuevRuslan MalikovichПалтуевРуслан Маликович

ФГУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития России

DashyanGarik Al'bertovichДашянГарик Альбертович

ФГУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития России

ManikhasAleksey GeorgievichМанихасАлексей Георгиевич

СПб. ГУЗ Городской клинический онкологический диспансе, Санкт-Петербург

Pen'kovKonstantin DmitrievichПеньковКонстантин Дмитриевич

ФГУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития России

SemiglazovaTat'yana Yur'evnaСемиглазоваТатьяна Юрьевна

ФГУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития России

TabaguaTengiz TengizovichТабагуаТенгиз Тенгизович

ФГУ НИИ онкологии им. Н.Н.Петрова Минздравсоцразвития России

Vasil'evAleksandr Gennad'evichВасильевАлександр Геннадьевич

ФГУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития России

Kolar'kovaVera Vital'evnaКоларьковаВера Витальевна

ФГУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития России

Krivorot'koPetr VladimirovichКриворотькоПетр Владимирович

ФГУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития России

NikitinaIrina VladimirovnaНикитинаИрина Владимировна

ФГУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития России

SemiglazovV FSemiglazovV VPaltuyevR MDashyanG AManihasA GPenkovK DSemiglazovaT YuTabaguaT TVasilyevA GKorolkovaV VKrivorotkoP VNikitinaI VФГУ НИИ онкологии им. Н.Н. Петрова Минздравсоцразвития РоссииСПГМУ им. академика И.П. ПавловаСПб. ГУЗ Городской клинический онкологический диспансе, Санкт-ПетербургФГУ НИИ онкологии им. Н.Н.Петрова Минздравсоцразвития России15042011187NO7 (2011)№7 (2011)81323022023Copyright ©; 2011, Bionika MediaCopyright ©; 2011, ООО «Бионика Медиа»2011Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2073-4034/article/view/278853

In 2010, therapy for breast cancer was determined by the fundamental biology of the tumor as measured by such prognostic markers of outcome as status of hormone receptors, HER2 expression and incremental molecular typing. These bioassays enlarge traditional staging in determining the risk of relapse, which had previously been the sole determinant for treatment planning. Small tumors with signs of high risk of recurrence require aggressive adjuvant therapy, whereas higher stage tumors with favorable biological characteristics may not require such therapy. Important prospective clinical trials integrating traditional and new markers of risk are currently under way to optimization of individualized treatment of patients with early (operable) breast cancer.

Терапия рака молочной железы в 2010 г. диктовалась основополагающей биологией опухоли, оцениваемой статусом гормональных рецепторов, экспрессией HER2 и нарастающим молекулярным типированием, служащими прогностическими маркерами исхода. Эти биооценки дополняют традиционное стадирование в определении риска рецидива заболевания, которое ранее являлось единственной детерминантой планирования лечения. Маленькие опухоли с признаками высокого риска рецидива нуждаются в агрессивной адъювантной терапии, в то время как опухоли более высоких стадий с благоприятными биологическими характеристиками могут не требовать такой терапии. Важные проспективные клинические испытания, интегрирующие классические и новые маркеры риска, проводятся в настоящее время с целью оптимизации индивидуализированного лечения больных ранним (операбельным) раком молочной железы.

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