PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media279667ArticlesСтатьиResearch ArticleInfektsionnoe obostrenie KhOBL: algoritm lecheniyaИнфекционное обострение ХОБЛ: алгоритм леченияAvdeevSergey NikolaevichАвдеевСергей Николаевич

доктор медицинских наук, профессор, руководитель клинического отдела

serg_avdeev@list.ruФГУ “НИИ пульмонологии” ФМБА России150620121911NO11 (2012)№11 (2012)485324022023Copyright ©; 2012, Bionika MediaCopyright ©; 2012, ООО «Бионика Медиа»2012Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2073-4034/article/view/279667

In patients, exacerbation of COPD is one of the most frequent causes of seeking emergency medical care. Among bacteria, nontypeable Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis play the most important role in the exacerbation of COPD. Current guidelines recommend the use of antibiotics in patients with more severe COPD exacerbations of, and suggest new approaches to the treatment based on phenotyping of COPD exacerbations and measurement of biomarkers. For the treatment of uncomplicated exacerbations of COPD, the use of modern macrolides, cephalosporins is recommended, and for the treatment of complicated exacerbations - amoxicillin/clavulanate or respiratory fluoroquinolones (moxifloxacin, levofloxacin).

Обострение ХОБЛ является одной из самых частых причин обращения больных за неотложной медицинской помощью. Среди бактерий наибольшую роль при обострении ХОБЛ играют нетипируемые Haemophilus influenzae, Streptococcus pneumoniae и Moraxella catarrhalis. Современные руководства рекомендуют назначать антибиотики пациентам с наиболее тяжелыми обострениями ХОБЛ, также предложены новые подходы к лечению, основанные на фенотипировании обострений ХОБЛ и определении уровней биомаркеров. При неосложненных обострениях ХОБЛ рекомендовано применение современных макролидов, цефалоспоринов, при осложненных - либо амоксициллина/клавуланата, либо респираторных фторхинолонов (моксифлоксацин, левофлоксацин).

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