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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pharmateca</journal-id><journal-title-group><journal-title xml:lang="en">Pharmateca</journal-title><trans-title-group xml:lang="ru"><trans-title>Фарматека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2073-4034</issn><issn publication-format="electronic">2414-9128</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">286673</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Rak molochnoy zhelezy i beremennost'</article-title><trans-title-group xml:lang="ru"><trans-title>Рак молочной железы и беременность</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dashyan</surname><given-names>G. A</given-names></name><name xml:lang="ru"><surname>Дашян</surname><given-names>Г. А</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., ведущий научный сотрудник отделения опухолей молочной железы</p></bio><email>dgarik@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Semiglazov</surname><given-names>V. F</given-names></name><name xml:lang="ru"><surname>Семиглазов</surname><given-names>В. Ф</given-names></name></name-alternatives><bio xml:lang="ru"><p>чл. -корр. РАМН, проф., рук. отдела опухолей репродуктивной системы и отделения опухолей молочной железы</p></bio><email>ssemiglazov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Topuzov</surname><given-names>E. E</given-names></name><name xml:lang="ru"><surname>Топузов</surname><given-names>Э. Э</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., проф., зав. кафедрой госпитальной хирургии</p></bio><email>eltop@inbox.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ivanov</surname><given-names>V. G</given-names></name><name xml:lang="ru"><surname>Иванов</surname><given-names>В. Г</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., зав. отделением химиотерапии опухолей молочной железы</p></bio><email>dr.ivanov@msn.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vorotnikov</surname><given-names>V. V</given-names></name><name xml:lang="ru"><surname>Воротников</surname><given-names>В. В</given-names></name></name-alternatives><bio xml:lang="ru"><p>лаборант отделения опухолей молочной железы</p></bio><email>flux.line@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lalak</surname><given-names>I. A</given-names></name><name xml:lang="ru"><surname>Лалак</surname><given-names>И. А</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант кафедры онкологии кафедрой онкологии</p></bio><email>grechukhinairina@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bryantseva</surname><given-names>Zh. V</given-names></name><name xml:lang="ru"><surname>Брянцева</surname><given-names>Ж. В</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант кафедры онкологии</p></bio><email>zhanna-dr@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Usungvan</surname><given-names>M. V</given-names></name><name xml:lang="ru"><surname>Усунгван</surname><given-names>М. В</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант кафедры госпитальной хирургии</p></bio><email>usungvan@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tseluyko</surname><given-names>A. I</given-names></name><name xml:lang="ru"><surname>Целуйко</surname><given-names>А. И</given-names></name></name-alternatives><bio xml:lang="ru"><p>клинический ординатор кафедры онкологии</p></bio><email>tselalex@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ФГБУ НИИ онкологии им. Н.Н. Петрова Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО СЗГМУ им. И.И. Мечникова Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО ПСПбГМУ им. акад. И.П. Павлова Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2014-02-20" publication-format="electronic"><day>20</day><month>02</month><year>2014</year></pub-date><volume>21</volume><issue>4</issue><issue-title xml:lang="en">NO4 (2014)</issue-title><issue-title xml:lang="ru">№4 (2014)</issue-title><fpage>18</fpage><lpage>22</lpage><history><date date-type="received" iso-8601-date="2023-02-26"><day>26</day><month>02</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2014, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2014, ООО «Бионика Медиа»</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2073-4034/article/view/286673">https://journals.eco-vector.com/2073-4034/article/view/286673</self-uri><abstract xml:lang="en"><p>This article discusses the effectiveness of various treatments used in the treatment of breast cancer (BC), developed on the background of pregnancy, in particular surgical treatment and chemotherapy, as well as the possibility of a subsequent pregnancy and breastfeeding after treatment of breast cancer. Less favorable long-term results of treatment of patients with breast cancer that arose during pregnancy can be explained by later revealing of tumor aggravating the prognosis, as well as the influence of young age of women sick. In the treatment of breast cancer against the background of pregnancy, it is necessary to carefully follow recommendations for treatment of non-pregnant patients in most cases. Treatment strategy should be determined individually in each case, taking into account the gestational age at diagnosis, stage of disease and the preferences of patient and her family.</p></abstract><trans-abstract xml:lang="ru"><p>В статье обсуждается эффективность различных методов лечения, используемых при лечении рака молочной железы (РМЖ), развившегося на фоне беременности, в частности хирургического лечения и химиотерапии, а также возможность последующей беременности и грудного вскармливания после лечения РМЖ. Менее благоприятные отдаленные результаты лечения больных РМЖ, возникшим в период беременности, объясняются запоздалым выявлением опухоли, отягощающим прогноз заболевания, а также влиянием молодого возраста заболевших женщин. При лечении РМЖ на фоне беременности в большинстве случаев необходимо точно следовать рекомендациям по лечению небеременных больных. Тактику лечения следует определять индивидуально в каждом конкретном случае с учетом гестационного возраста на момент постановки диагноза, стадии заболевания, предпочтений больной и ее семьи.</p></trans-abstract><kwd-group xml:lang="en"><kwd>breast cancer</kwd><kwd>pregnancy</kwd><kwd>breastfeeding</kwd><kwd>chemotherapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рак молочной железы</kwd><kwd>беременность</kwd><kwd>грудное вскармливание</kwd><kwd>химиотерапия</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Pavlidis N.A. Coexistence of pregnancy and malignancy. Oncologist. 2002;7:279-87.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Cardonick E., Dougherty R., Grana G, et al. Breast cancer during pregnancy: maternal and fetal outcomes. Cancer J. 2010;16(1):76-82.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Dominici L.S., Kuerer H.M., Babiera G., et al. Wound complications from surgery in pregnancy-associated breast cancer (PABC). Breast Dis. 2010;31(1):1-5.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>National Comprehensive Cancer Network. NCCN guidelines version 3.2012 Breast Cancer. Available at: http://www.nccn.org/professionals/physician_gls/ pdf/breast.pdf. Accessed January 15, 2013.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Amant F., Loibl S., Neven P., et al. Breast cancer in pregnancy. Lancet. 2012;379(9815):570-79.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Gentilini O., Cremonesi M., Toesca A., et al. Sentinel lymph node biopsy in pregnant patients with breast cancer. Eur. J. Nucl. Med. Mol. Imaging. 2010;37(1):78-83.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Keleher A., Wendt R., Delpassand E., et al. The safety of lymphatic mapping in pregnant breast cancer patients using Tc-99m sulfur colloid. Breast J. 2004;10(6):492-95.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Loibl S., von Minckwitz G., Gwyn K., et al. Breast carcinoma during pregnancy. International recommendations from an expert meeting. Cancer. 2006;106(2):237-46.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Cohn D., Ramaswamy B., Blum K. Malignancy and pregnancy. In: Creasy R., lams J., Resnik R., eds. Maternal-fetal medicine principles and practice. 6th edition. Toronto: WB Saunders, 2010:885-904.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Hahn K.M., Johnson P.H., Gordon N., et al. Treatment of pregnant breast cancer patients and outcomes of children exposed to chemotherapy in utero. Cancer. 2006;107(6):1219-26.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Cardonick E., Bhat A., Gilmandyar D., et al. Maternal and fetal outcomes of taxane chemotherapy in breast and ovarian cancer during pregnancy: case series and review of the literature. Ann. Oncol. 2012;23(12):3016-23.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Mir O., Berveiller P., Goffinet F., et al. Taxanes for breast cancer during pregnancy: a systematic review. Ann. Oncol. 2010;21(2):425-26.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Azim H.A. Jr, Santoro L., Pavlidis N., et al. Safety of pregnancy following breast cancer diagnosis: a meta-analysis of 14 studies. Eur. J. Cancer. 2011;47:74-83.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Sankila R., Heinavaara S., Hakulinen T. Survival of breast cancer patients after subsequent term pregnancy: «healthy mother effect». Am. J. Obstet. Gynecol. 1994;170:818-23.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Asztalos S., Gann P.H., Hayes M.K., et al. Gene expression patterns in the human breast after pregnancy. Cancer Prev. Res. (Philadelphia). 2010;3:301-11.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Azim H.A. Jr, Peccatori F.A., de Azambuja E., Piccart M.J. Motherhood after breast cancer: searching for la dolce vita. Expert Rev. Anticancer Ther. 2011;11:287-98.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Pagani O., Price K.N., Gelber R.D., et al. Patterns of recurrence of early breast cancer according to estrogen receptor status: a therapeutic target for a quarter of a century. Breast Cancer Res Treat. 2009;117:319-24.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Jatoi I., Anderson W.F., Jeong J.H., Redmond C.K. Breast cancer adjuvant therapy: time to consider its time-dependent effects. J. Clin. Oncol. 2011;29:2301-304.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Gnant M., Mlineritsch B., Stoeger H., et al. Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial. Lancet Oncol. 2011;12:631-41.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet. 2005; 365:1687-717.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Chie W.C., Hsieh C., Newcomb P.A., et al. Age at any full-term pregnancy and breast cancer risk. Am J Epidemiol 2000;151:715-22.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Andrieu N., Goldgar D.E., Easton D.F., et al. Pregnancies, breast-feeding, and breast cancer risk in the International BRCA1/2 Carrier Cohort Study (IBCCS). J. Natl. Cancer Inst. 2006;98:535-44.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Pagani O., Partridge A., Korde L., et al. Pregnancy after breast cancer: if you wish, ma'am. Breast Cancer Res. Treat. 2011;129:309-17.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Lee S.J., Schover L.R., Partridge A.H., et al. American Society of Clinical Oncology recommendations on fertility preservation in cancer patients. J. Clin. Oncol. 2006;24:2917-31.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Anderson R.A., Cameron D.A. Pretreatment serum anti-mullerian hormone predicts longterm ovarian function and bone mass after chemotherapy for early breast cancer. J. Clin. Endocrinol. Metab. 2011;96:1336-43.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Su H.I., Sammel M.D., Green J., et al. Antimullerian hormone and inhibin B are hormone measures of ovarian function in late reproductive-aged breast cancer survivors. Cancer. 2010;116:592-99.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Lutchman S.K., Muttukrishna S., Stein R.C., et al. Predictors of ovarian reserve in young women with breast cancer. Br. J. Cancer. 2007;96:1808-16.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Scheffer G.J., Broekmans F.J., Looman C.W., et al. The number of antral follicles in normal women with proven fertility is the best reflection of reproductive age. Hum. Reprod. 2003;18:700-6.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>de Bree E., Makrigiannakis A., Askoxylakis J., et al. Pregnancy after breast cancer. A comprehensive review. J. Surg. Oncol. 2010;101:534-42.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Langagergaard V., Gislum M., Skriver M.V., et al. Birth outcome in women with breast cancer. Br. J. Cancer. 2006;94:142-46.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Dow K.H., Harris J.R., Roy C. Pregnancy after breast-conserving surgery and radiation therapy for breast cancer. J. Natl. Cancer Inst. Monogr. 1994:131-37.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Malamos N.A., Stathopoulos G.P., Keramopoulos A., et al. Pregnancy and offspring after the appearance of breast cancer. Oncology. 1996;53:471-75.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Dalberg K., Eriksson J., Holmberg L. Birth outcome in women with previously treated breast cancer a population-based cohort study from Sweden. PLoS Med. 2006;3:e336.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Velentgas P., Daling J.R., Malone K.E., et al. Pregnancy after breast carcinoma: outcomes and influence on mortality. Cancer. 1999; 85:2424-32.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Section on Breastfeeding. Breastfeeding and the use of human milk. Pediatrics 2012; 129:e827-41.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Azim A.H. Jr, de Azambuja E., Colozza M., et al. Long-term toxic effects of adjuvant chemotherapy in breast cancer. Ann. Oncol. 2011; 22:1939-47.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Gelber S., Coates A.S., Goldhirsch A., et al. Effect of pregnancy on overall survival after the diagnosis of early-stage breast cancer. J. Clin. Oncol. 2001;19:1671-75.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Azim H.A. Jr, Bellettini G., Liptrott S.J., et al. Breastfeeding in breast cancer survivors: pattern, behaviour and effect on breast cancer outcome. Breast. 2010;19:527-31.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Azim H.A. Jr, Bellettini G., Gelber S., Peccatori F.A. Breast-feeding after breast cancer: if you wish, madam. Breast Cancer Res. Treat. 2009; 114:7-12.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Higgins S., Haffty B.G. Pregnancy and lactation after breast-conserving therapy for early stage breast cancer. Cancer. 1994;73:2 1 75-80.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Moran M.S., Colasanto J.M., Haffty B.G., et al. Effects of breast-conserving therapy on lactation after pregnancy. Cancer J. 2005;11:399-403.</mixed-citation></ref></ref-list></back></article>
