PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media287454ArticlesСтатьиResearch ArticleNovye preparaty, vosstanavlivayushchie immunnyy kontrol' nad opukhol'yu v terapii patsientov s metastaticheskoy melanomoyНовые препараты, восстанавливающие иммунный контроль над опухолью в терапии пациентов с метастатической меланомойKharkevichG. YuХаркевичГ. Ю

к.м.н., ведущий научный сотрудник, отделение биотерапии опухолей

gkharkevich@mail.ruOrlovaK. VОрловаК. В

врач-онколог, отделение биотерапии опухолей

krisman03@gmail.comDemidovL. VДемидовЛ. В

д.м.н., проф., зав. отделением биотерапии опухолей

ФГБНУ «РОНЦ им. Н.Н. Блохина»ФГБНУ «РОНЦим. Н.Н. Блохина»100920142117NO17 (2014)№17 (2014)253126022023Copyright ©; 2014, Bionika MediaCopyright ©; 2014, ООО «Бионика Медиа»2014Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2073-4034/article/view/287454

Treatment of disseminated melanoma many years remained challenging. Standard chemotherapy had no fundamentally effect on overall survival of patients. Given the high immunogenicity of the tumor, immunotherapy of melanoma was always the center of attention of researchers. However, the first real success of immunotherapy for metastatic melanoma is associated with the emergence of a new generation of immunotherapeutic drugs - inhibitors of regulatory molecules of key stages of the immune response. The article describes the main drugs of this group, and the latest results from clinical studies conducted in disseminated melanoma are presented.

Лечение диссеминированной меланомы кожи долгие годы оставалось сложной задачей. Проведение стандартной химиотерапии не оказывало принципиального влияния на общую продолжительность жизни пациентов. С учетом высокой иммуногенности опухоли иммунотерапия меланомы всегда была в центре внимания исследователей. Но первые реальные успехи иммунотерапии при метастатической меланоме связаны с появлением нового поколения иммунотерапевтических препаратов - ингибиторов регуляторных молекул ключевых этапов иммунного ответа. В статье рассмотрены основные препараты данной группы, представлены последние результаты клинических исследований, проведенных при диссеминированной меланоме.

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