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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pharmateca</journal-id><journal-title-group><journal-title xml:lang="en">Pharmateca</journal-title><trans-title-group xml:lang="ru"><trans-title>Фарматека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2073-4034</issn><issn publication-format="electronic">2414-9128</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">287537</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Tromboliticheskaya terapiya pri ishemicheskom insul'te: prediktory bezopasnosti i effektivnosti</article-title><trans-title-group xml:lang="ru"><trans-title>Тромболитическая терапия при ишемическом инсульте: предикторы безопасности и эффективности</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shamalov</surname><given-names>N. A</given-names></name><name xml:lang="ru"><surname>Шамалов</surname><given-names>Н. А</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н,. проф. кафедры фундаментальной и клинической неврологии и нейрохирургии, зав. отделением лечения и диагностики инсульта НИИ цереброваскулярной патологии и инсульта</p></bio><email>shamalovn@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Anisimov</surname><given-names>K. V</given-names></name><name xml:lang="ru"><surname>Анисимов</surname><given-names>К. В</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., врач-невролог отделения лечения и диагностики инсульта НИИ цереброваскулярной патологии и инсульта</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kustova</surname><given-names>M. A</given-names></name><name xml:lang="ru"><surname>Кустова</surname><given-names>М. А</given-names></name></name-alternatives><bio xml:lang="ru"><p>ассистент кафедры фундаментальной и клинической неврологии и нейрохирургии</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tolmachev</surname><given-names>A. P</given-names></name><name xml:lang="ru"><surname>Толмачев</surname><given-names>А. П</given-names></name></name-alternatives><bio xml:lang="ru"><p>ст. лаборант кафедры фундаментальной и клинической неврологии и нейрохирургии</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Biryukov</surname><given-names>V. V</given-names></name><name xml:lang="ru"><surname>Бирюков</surname><given-names>В. В</given-names></name></name-alternatives><bio xml:lang="ru"><p>зав. отделением реанимации и интенсивной терапии для больных с острыми нарушениями мозгового кровообращения</p></bio><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО РНИМУ им. Н.И. Пирогова Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Городская клиническая больница № 31, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2014-10-10" publication-format="electronic"><day>10</day><month>10</month><year>2014</year></pub-date><volume>21</volume><issue>19</issue><issue-title xml:lang="en">NO19 (2014)</issue-title><issue-title xml:lang="ru">№19 (2014)</issue-title><fpage>30</fpage><lpage>35</lpage><history><date date-type="received" iso-8601-date="2023-02-26"><day>26</day><month>02</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2014, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2014, ООО «Бионика Медиа»</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2073-4034/article/view/287537">https://journals.eco-vector.com/2073-4034/article/view/287537</self-uri><abstract xml:lang="en"><p>A systemic thrombolytic therapy with account of clinical and pathogenetic features of the disease, localization of the lesion, results of additional methods of diagnosis (primarily neuroimaging), identification of predictors for bleeding complications will contribute to safer and more effective use of this method for the treatment of patients with ischemic stroke.</p></abstract><trans-abstract xml:lang="ru"><p>Проведение системной тромболитической терапии с учетом клинико-патогенетических особенностей заболевания, локализации очага поражения, данных дополнительных методов исследования (в первую очередь нейровизуализации), выявления предикторов геморрагических осложнений будет способствовать более безопасному и эффективному применению данного метода лечения со стороны пациентов с ишемическим инсультом.</p></trans-abstract><kwd-group xml:lang="en"><kwd>ischemic stroke</kwd><kwd>thrombolytic therapy</kwd><kwd>recombinant tissue-type plasminogen activator</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>ишемический инсульт</kwd><kwd>тромболитическая терапия</kwd><kwd>рекомбинантный тканевой активатор плазминогена</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>http: //www.eso-stroke.org</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Jauch E.C., Saver J.L., Adams HP Jr., et al.; American Heart Association Stroke Council; Council on Cardiovascular Nursing; Council on Peripheral Vascular Disease; Council on Clinical Cardiology.Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/ American Stroke Association. 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