<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pharmateca</journal-id><journal-title-group><journal-title xml:lang="en">Pharmateca</journal-title><trans-title-group xml:lang="ru"><trans-title>Фарматека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2073-4034</issn><issn publication-format="electronic">2414-9128</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">287930</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Kompleksnoe lechenie bol'nykh s tserebral'nymi metastazami kolorektal'nogo raka</article-title><trans-title-group xml:lang="ru"><trans-title>Комплексное лечение больных с церебральными метастазами колоректального рака</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Karakhan</surname><given-names>V. B</given-names></name><name xml:lang="ru"><surname>Карахан</surname><given-names>В. Б</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., проф., в.н.с. нейрохирургического (онкологического) отделения</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Naskhletashvili</surname><given-names>D. R</given-names></name><name xml:lang="ru"><surname>Насхлеташвили</surname><given-names>Д. Р</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., с.н.с. нейрохирургического (онкологического) отделения</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mitrofanov</surname><given-names>A. A</given-names></name><name xml:lang="ru"><surname>Митрофанов</surname><given-names>А. А</given-names></name></name-alternatives><bio xml:lang="ru"><p>н.с. нейрохирургического (онкологического) отделения</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ФГБНУ«Российский онкологический научный центр им. Н.Н. Блохина»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-04-20" publication-format="electronic"><day>20</day><month>04</month><year>2015</year></pub-date><volume>22</volume><issue>8</issue><issue-title xml:lang="en">NO8 (2015)</issue-title><issue-title xml:lang="ru">№8 (2015)</issue-title><fpage>37</fpage><lpage>39</lpage><history><date date-type="received" iso-8601-date="2023-02-26"><day>26</day><month>02</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, ООО «Бионика Медиа»</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2073-4034/article/view/287930">https://journals.eco-vector.com/2073-4034/article/view/287930</self-uri><abstract xml:lang="en"><p>The article presents the results of treatment of 30 patients with cerebral metastases from colorectal cancer. The morphological and radiological patterns of metastatic nodes, surgical options and the frequency of local recurrences, postoperative chemoradiation therapy, as well as the causes of death in this group of patients are discussed.</p></abstract><trans-abstract xml:lang="ru"><p>В статье приводятся результаты комплексного лечения 30 пациентов с церебральными метастазами колоректального рака. Обсуждаются морфо-рентгенологическая структура метастатических узлов, варианты хирургического лечения и частота локальных рецидивов, послеоперационная химиолучевая терапия, а также причины смерти среди данной группы больных.</p></trans-abstract><kwd-group xml:lang="en"><kwd>colorectal cancer</kwd><kwd>cerebral metastases</kwd><kwd>combined treatment</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>колоректальный рак</kwd><kwd>метастазы в головном мозге</kwd><kwd>комбинированное лечение</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Curado M.P, Edwards B., Shin H.R., Storm H., Ferlay J., Heanue M., Boyle P. Cancer incidence in five continents: Volume IX. IARC. 2007. P. 896.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Jemal A., Siegel R., Xu J., Ward E. Cancer statistics, 2010. CA Cancer J. Clin. 2010;60(5): 277-300.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Злокачественные новообразования в России в 2007 году (заболеваемость и смертность) / Под ред. В.И. Чиссова, В.В.Старинского, Г.В. Петровой. М.2009. 252 с.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Baek J.Y., Kang M.H., Hong Y.S., Kim T.W. Characteristics and prognosis of patients with colorectal cancer-associated brain metastases in the era of modern systemic chemotherapy. J. Neurooncol. 2011; Feb 19. [Epub ahead of print]</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Jung M., Ahn J.B., Chang J.H. Brain metastases from colorectal carcinoma: prognostic factors and outcome. J. Neurooncol. 2011; 101(1):49-55.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Patchell R.A. Metastatic brain tumors. Neurol. Clin. 1995;13:915-25.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Wroriski M., Arbit E. Resection of brain metastases from colo-rectal carcinoma in 73 patients. Cancer. 1999;85:1677-685.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Sundermeyer M.L., Meropol N.J., Rogatko A. Changing patterns of bone and brain metastases in patients with colorectal cancer. Clin. Colorectal Cancer. 2005;5(2):108-13.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Gutenberg A., Gerdes J.S., Jung K., Sander B. High chromosomal instability in brain metastases of colorectal carcinoma. Cancer Genet Cytogenet. 2010;198(1):47-51.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Tie J., Lipton L., Desai J., Gibbs P., Jorissen R.N. KRAS mutation is associated with lung metastasis in patients with curatively resected colorectal cancer. Clin. Cancer Res. 2011;17(5): 1122-30.</mixed-citation></ref></ref-list></back></article>
