PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media287935ArticlesСтатьиReview ArticleNovye napravleniya v targetnoy terapii nemelkokletochnogo raka legkogoНовые направления в таргетной терапии немелкоклеточного рака легкогоShikeevaA. AШикееваА. А

к.м.н., м.н.с. сектора молекулярно-биологических исследований НИЦ; н.с. лаборатории эпигенетики

KekeevaT. VКекееваТ. В

доцент кафедры патологической анатомии; к.м.н., в.н.с. лаборатории эпигенетики

ZavalishinaL. EЗавалишинаЛ. Э

д.б.н., проф. кафедры патологической анатомии

AndreevaYu. YuАндрееваЮ. Ю

д.м.н., проф. кафедры патологической анатомии

ZaletaevD. VЗалетаевД. В

д.б.н., проф. зав. лабораторией эпигенетики

FrankG. AФранкГ. А

д.м.н., проф., акад. РАН, зав. кафедрой патологической анатомии

ГБОУ ДПО «Российская медицинская академия последипломного образования» Минздрава РоссииФГБНУ «Медико-генетический научный центр»ФГБНУ «Медико-генетический научный центр»ГБОУ ДПО «Российская медицинская академия последипломного образования» Минздрава России20042015228NO8 (2015)№8 (2015)475226022023Copyright ©; 2015, Bionika MediaCopyright ©; 2015, ООО «Бионика Медиа»2015Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2073-4034/article/view/287935

Group of non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancers, one of the most common oncological diseases. About ten years ago, cytotoxic therapy was the single therapeutic option for patients with NSCLC. Currently in oncology, there is era of targeted therapies and personalized approach to the choice of tactics of treatment of patients with malignant tumors, including NSCLC. The study of genetic disorders has led to the creation of targeted therapies for the treatment of this tumor type: some of them are high effective and has already been successfully used in clinical practice, while others are in various stages of clinical trials. This article considers the molecular genetic abnormalities in NSCLC, their clinical importance and potentials for the use of targeted therapy.

Группа немелкоклеточного рака легкого (НМРЛ) составляет 85% всех раков легкого, одного из самых распространенных онкологических заболеваний. Около 10 лет назад единственной терапевтической возможностью для пациентов с НМРЛ была цитотоксическая терапия. В настоящее время в онкологии наступила эра таргетной терапии и персонализированного подхода к выбору тактики лечения пациентов со злокачественными новообразованиями, в т.ч. и НМРЛ. Исследование генетических нарушений привело к созданию таргетных препаратов для лечения данного типа опухоли - одни из них оказались высокоэффективными и уже успешно применяются в клинической практике, другие находятся на различных стадиях клинических испытаний. В данной статье рассматриваются молекулярно-генетические нарушения при НМРЛ, их клиническое значение и возможности применения таргетной терапии.

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