PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media289216ArticlesСтатьиResearch ArticleMARKERS OF GASTROESOPHAGEAL REFLUX DISEASE IN THEORY AND PRACTICEМаркеры гастроэзофагеальной рефлюксной болезни в теории и практикеPlotnikovaE. YuПлотниковаЕ. Ю

MD, Head of the Course of Gastroenterology at the Department of Postgraduate Training of Primary Care Physicians and Emergency Care

д.м.н., рук. курса гастроэнтерологии кафедры постдипломной подготовки врачей первичного звена здравоохранения и СМП

eka-pl@rambler.ruVologzhaninaL. GВологжанинаЛ. ГSamsonovA. AСамсоновА. АSamsonovaO. AСамсоноваО. АAndreevD. NАндреевД. НSBEIHPE KemSMU of RMHГБОУ ВПО КемГМУ Минздрава РоссииSBEI HPE PSMU n.a. Acad. E.A. Wagner of RMHГБОУ ВПО ПГМУ им. акад. Е.А. Вагнера Минздрава РФSBEI HPE "Moscow State Medical Stomatological University n.a. A.I. Evdokimov" of RMHГБОУ ВПО МГМСУ им. А.И. Евдокимова Минздрава РФSpecialized Gastroenterological Center, PermСпециализированный гастроэнтерологический центр, Пермь100820162315NO15 (2016)№15 (2016)253326022023Copyright ©; 2016, Bionika MediaCopyright ©; 2016, ООО «Бионика Медиа»2016Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2073-4034/article/view/289216

The article discusses the current problems of gastroesophageal reflux disease (GERD), and the possibility of its diagnosis at the current stage. A review to find reliable specific and sensitive biomarkers of GERD, such as indicators of the synthesis or degradation of tight intercellular junctions, basal impendancemetry and a number of others is presented. The results of examination of patients with GERD who visited specialized Gastroenterology Center of Perm are provided. The features of clinical manifestation, results of endoscopic and histological examinations of the esophagus in patients of different ages and duration of the disease course are discussed. Our data allow to reach more differentiated and individual approach to the appointment of treatment regimens for GERD taking into account all the features.

В статье обсуждаются актуальные проблемы гастроэзофагеальной рефлюксной болезни (ГЭРБ) и возможности ее диагностики на современном этапе. Приводится обзор по поиску надежных специфичных и чувствительных биомаркеров ГЭРБ, таких как проявления синтеза или деградации плотных межклеточных соединений, базовой импендансометрии и ряда других. Представлены результаты обследования пациентов с ГЭРБ, обратившихся в специализированный Гастроэнтерологический центр Перми. Рассмотрены особенности клинической картины, эндоскопического и гистологического исследований пищевода у пациентов разных возрастов и длительности течения заболевания. Наши данные позволяют более дифференцированно и индивидуально подходить к назначению схем лечения при ГЭРБ с учетом всех особенностей.

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