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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pharmateca</journal-id><journal-title-group><journal-title xml:lang="en">Pharmateca</journal-title><trans-title-group xml:lang="ru"><trans-title>Фарматека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2073-4034</issn><issn publication-format="electronic">2414-9128</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">289721</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">PHARMACOTHERAPY OF MULTIPLE SCLEROSIS: TREATMENT OF EXACERBATIONS, IMMUNOMODULATORY THERAPY</article-title><trans-title-group xml:lang="ru"><trans-title>ФАРМАКОТЕРАПИЯ РАССЕЯННОГО СКЛЕРОЗА: ЛЕЧЕНИЕ ОБОСТРЕНИЙ, ИММУНОМОДУЛИРУЮЩАЯ ТЕРАПИЯ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kurapov</surname><given-names>M. A</given-names></name><name xml:lang="ru"><surname>Курапов</surname><given-names>М. А</given-names></name></name-alternatives><bio xml:lang="en"><p>neurologist at the Center of Demyelinating Diseases and Multiple Sclerosis of the Samara region</p></bio><bio xml:lang="ru"><p>врач-невролог Центра демиелинизирующих заболеваний и рассеянного склероза Самарской области</p></bio><email>kurapovmichael@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vlasov</surname><given-names>Ya. V</given-names></name><name xml:lang="ru"><surname>Власов</surname><given-names>Я. В</given-names></name></name-alternatives><bio xml:lang="en"><p>Department of Neurology and Neurosurgery</p></bio><bio xml:lang="ru"><p>Кафедра неврологии и нейрохирургии</p></bio><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">SBHCI Samara Regional Clinical Hospital n.a. V.D. Seredavin</institution></aff><aff><institution xml:lang="ru">ГБУЗ «Самарская областная клиническая больница им. В.Д. Середавина»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">FSBEI HE “Samara State Medical University" of RMH</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Самарский государственный медицинский университет» Минздрава РФ</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-11-20" publication-format="electronic"><day>20</day><month>11</month><year>2016</year></pub-date><volume>23</volume><issue>4S</issue><issue-title xml:lang="en">NOs4 (2016)</issue-title><issue-title xml:lang="ru">№s4 (2016)</issue-title><fpage>24</fpage><lpage>27</lpage><history><date date-type="received" iso-8601-date="2023-02-26"><day>26</day><month>02</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, ООО «Бионика Медиа»</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2073-4034/article/view/289721">https://journals.eco-vector.com/2073-4034/article/view/289721</self-uri><abstract xml:lang="en"><p>Currently, treatment of multiple sclerosis is one of the most serious problems of modern medicine. The article discusses the problems of pharmacotherapy of patients during exacerbation, tactics of conversion from first-line drugs to second-line drugs, the use of multiple sclerosis disease modifying drugs.</p></abstract><trans-abstract xml:lang="ru"><p>Лечение рассеянного склероза в настоящее время является одной из наиболее серьезных проблем современной медицины. В статье обсуждаются проблемы фармакотерапии пациентов в стадии обострения, тактика перехода с препаратов первой линии на препараты второй линии, применение препаратов, изменяющих течение рассеянного склероза.</p></trans-abstract><kwd-group xml:lang="en"><kwd>multiple sclerosis</kwd><kwd>drug therapy</kwd><kwd>pharmacotherapy</kwd><kwd>pulse therapy</kwd><kwd>multiple sclerosis disease modifying drugs</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рассеянный склероз</kwd><kwd>лекарственная терапия</kwd><kwd>фармакотерапия</kwd><kwd>пульс-терапия</kwd><kwd>препараты</kwd><kwd>изменяющие течение рассеянного склероза</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Аутоиммунные заболевания в неврологии / Под ред. И.А. Завалишина, М.А. Пирадова, А.Н. Бойко, С.С. Никитина, Н.Н. Спирина, А.В. Переседовой Клиническое руководство. М., 2014. 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