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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pharmateca</journal-id><journal-title-group><journal-title xml:lang="en">Pharmateca</journal-title><trans-title-group xml:lang="ru"><trans-title>Фарматека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2073-4034</issn><issn publication-format="electronic">2414-9128</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">289979</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Suppression of progression of renal dysfunction and cerebrovascular events: potentials of atorvastatin</article-title><trans-title-group xml:lang="ru"><trans-title>Торможение прогрессирования почечной дисфункции и цереброваскулярных событий: возможности аторвастатина</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Murkamilov</surname><given-names>I. T</given-names></name><name xml:lang="ru"><surname>Муркамилов</surname><given-names>И. Т</given-names></name></name-alternatives><bio xml:lang="en"><p>PhD, Nephrologist of the First Qualification Category, Teaching Assistant at the Department of Faculty Therapy</p></bio><bio xml:lang="ru"><p>к.м.н., врач-нефролог I квалификационной категории, ассистент кафедры факультетской терапии</p></bio><email>murkamilov.i@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Aitbayev</surname><given-names>K. A</given-names></name><name xml:lang="ru"><surname>Айтбаев</surname><given-names>К. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fomin</surname><given-names>V. V</given-names></name><name xml:lang="ru"><surname>Фомин</surname><given-names>В. В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rayimzhanov</surname><given-names>Z. R</given-names></name><name xml:lang="ru"><surname>Райимжанов</surname><given-names>З. Р</given-names></name></name-alternatives><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Redzhapova</surname><given-names>N. A</given-names></name><name xml:lang="ru"><surname>Реджапова</surname><given-names>Н. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff6"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Yusupov</surname><given-names>F. A</given-names></name><name xml:lang="ru"><surname>Юсупов</surname><given-names>Ф. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff6"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Aydarov</surname><given-names>Z. A</given-names></name><name xml:lang="ru"><surname>Айдаров</surname><given-names>З. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff7"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kyrgyz State Medical Academy n.a. I.K Akhunbayev</institution></aff><aff><institution xml:lang="ru">Кыргызская государственная медицинская академия им. И.К. Ахунбаева</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Kyrgyz Russian Slavic University n.a. the First President of Russia B.N. Yeltsin</institution></aff><aff><institution xml:lang="ru">Кыргызско-Российский Славянский университет им. первого Президента России Б.Н. Ельцина</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Scientific Research Institute of Molecular Biology and Medicine</institution></aff><aff><institution xml:lang="ru">Научно-исследовательский институт молекулярной биологии и медицины</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">FSAEI HE First Moscow State Medical University n.a. I.M. Sechenov of RMH</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">FSBI «Main Military Clinical Hospital n.a. Acad. N.N. Burdenko»of the Ministry of Defense of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГКУ «Главный военный клинический госпиталь им. акад. Н.Н. Бурденко» Министерства обороны РФ</institution></aff></aff-alternatives><aff-alternatives id="aff6"><aff><institution xml:lang="en">Osh State University</institution></aff><aff><institution xml:lang="ru">Ошский государственный университет</institution></aff></aff-alternatives><aff-alternatives id="aff7"><aff><institution xml:lang="en">Kyrgyz State Medical Academy n.a. I.K Akhunbayev</institution></aff><aff><institution xml:lang="ru">Кыргызская государственная медицинская академия им. И.К Ахунбаева</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-08-10" publication-format="electronic"><day>10</day><month>08</month><year>2017</year></pub-date><volume>24</volume><issue>15</issue><issue-title xml:lang="en">NO15 (2017)</issue-title><issue-title xml:lang="ru">№15 (2017)</issue-title><fpage>74</fpage><lpage>82</lpage><history><date date-type="received" iso-8601-date="2023-02-26"><day>26</day><month>02</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, ООО «Бионика Медиа»</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2073-4034/article/view/289979">https://journals.eco-vector.com/2073-4034/article/view/289979</self-uri><abstract xml:lang="en"><p>The article discusses the pathogenetic mechanisms of the development of renal dysfunction in hyperlipidemia. The data on the study of the role of statins, in particular atorvastatin, in the progression of nephrocerebral interrelations are presented. The results of a number of studies demonstrating the nephro- and cerebroprotective properties of atorvastatin have been analyzed.</p></abstract><trans-abstract xml:lang="ru"><p>В статье обсуждаются патогенетические механизмы формирования почечной дисфункции при гиперлипидемии. Представлены данные по изучению роли статинов, в частности аторвастатина, в прогрессировании нефроцеребральных взаимоотношений. Проанализированы результаты ряда исследований, свидетельствующих о нефро- и церебропротективных свойствах аторвастатина.</p></trans-abstract><kwd-group xml:lang="en"><kwd>chronic kidney disease</kwd><kwd>glomerular filtration rate</kwd><kwd>hyperlipidemia</kwd><kwd>cerebrovascular diseases</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>хроническая болезнь почек</kwd><kwd>скорость клубочковой фильтрации</kwd><kwd>гиперлипидемия</kwd><kwd>цереброваскулярные заболевания</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Фомин В.В., Рогова И.В., Дамулин И.В., Мухин Н.А. Особенности формирования когнитивных расстройств на додиализных стадиях хронической болезни почек. Журнал неврол. и психиатр. им. С.С. Корсакова. 2015;12:25-30.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Рогова И.В., Фомин В.В., Дамулин И.В., Мухин Н.А. Умеренные когнитивные расстройства при хронической болезни почек: клинико-патогенетические особенности, факторы риска, лечение. Клин. нефрология. 2012;5:4-8.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Laurent S., Boutouyrie P. Arterial stiffness: a new surrogate end point for cardiovascular disease?J. Nephrol. 2007;20(12):45-50.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Ni J., Ma K. L., Wang C.X., Liu J., Zhang Y., Lv L.L., Ni H.F., Chen Y.X., Ruan X.Z., Liu B.C. Activation of renin-angiotensin system is involved in dyslipidemia-mediated renal injuries in apolipoprotein E knockout mice and HK-2 cells. Lipids in health and disease. 2013;12(1):49.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Favre G.A., Esnault V.L.M., Van Obberghen E. Modulation of glucose metabolism by the renin-angiotensin-aldosterone system. Am. J. PhysioL-Endocrin. Metabol. 2015;308(6):435-49.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Мухин Н.А., Фомин В.В., Дамулин И.В., Рогова И.В. Хроническая болезнь почек и сосудистая деменция. Тер. архив. 2014;6:7-10.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Nayak-Rao S., Shenoy M.P Stroke in patients with chronic kidney disease. How do we approach and manage it? Ind. J. Nephrol. 2017;27:167-71.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Moorhead J.F., Chan M.K., El-Nahas M., Varghese Z. Lipid nephrotoxicity in chronic progressive glomerular and tubulo-interstitial disease. Lancet. 1982;2:1309-11.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Смирнов А.В. Характеристика дислипопротеидемий у больных гломерулонефритом. Нефрология. 1998;2(3):76-83.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Wheeler D.C., Chana R.S: Interactions between lipoproteins, glomerular cells and matrix. Miner. Electrolyte Metab. 1993; 19(3);149-64.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Kramer-Guth A., Nauck M., Pavenstädt H., Königer M., Wieland H., Schollmeyer P., Wanner C. Preferential uptake of intermediatedensity lipoproteins from nephrotic patients by human mesangial and liver cells. J. Am. Soc. Nephrol. 1994;5:1081-90.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Joles J.A., Kunter U.T.A., Janssen U., Kriz W., Rabelink T.J., Koomans H.A., Floege J. Early mechanisms of renal injury in hypercholesterolemic or hypertriglyceridemic rats. J. Am. Soc. Nephrol. 2000;11(4):669-83.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Тареева И.Е. Нефрология. Руководство для врачей. 2000. 688 с.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Моисеев В.С., Мухин Н.А., Смирнов А.В., Кобалава Ж.Д., Бобкова И.Н., Виллевальде С.В., Ефремовцева М.А., Козловская Л.В., Швецов М.Ю., Шестакова М.В., Арутюнов Г.П. и др. Сердечно-сосудистый риск и хроническая болезнь почек: стратегии кардионефропротекции. Клин. фармакология и терапия. 2014;23(3):4-27.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Mikolasevic I., Žutelija M., Mavrinac V. Dyslipidemia in patients with chronic kidney disease: etiology and management. Int. J. Nephrol. Renovasc. Dis. 2017;10:35-45. doi:10.2147/IJNRD.S101808.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Honore P/M.,Jacobs R., Hendrickx I., De Waele E., Van Gorp V., De Regt J., Spapen H.D. Statins and the Kidney: Friend or Foe? Blood Purif. 2017;43(1-3):91-6.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>de Zeeuw D., Anzalone D.A., Cain V.A., Cressman M.D., Heerspink H.J., Molitoris B.A., Monyak J.T., Parving H.H., Remuzzi G., Sowers J.R., Vidt D.G. Renal effects of atorvastatin and rosuvastatin in patients with diabetes who have progressive renal disease (PLANET I): a randomised clinical trial. The lancet Diabetes &amp; endocrinology. 2015;3(3):181-90.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Reiner Z., Catapano A.L., De Backer G., Graham I., Taskinen M.R., Wiklund O., Agewall S., Alegria E., Chapman M.J., Durrington P., Erdine S., Halcox J., Hobbs R., Kjekshus J., Filardi P.P., Riccardi G., Storey R.F., Wood D. ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur. Heart J. 2011;32:1769-818.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Chaplin S. NICE statins guidance: prevention of cardiovascular events. Prescriber. 2006;17(4):58-60.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Jones P.H. Comparing HMG-GoA reductase inhibitors. Clin. Cardiol. 2003;26:115-20.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Goldstein J.L., Brown M.S. Regulation of the mevalonate pathway. Nature. 1990; 343:425-30.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Catapano A.L., Graham I., De Backer G., Wiklund O., Chapman M.J., Drexel H., Hoes A.W., Jennings C.S., Landmesser U., Pedersen T.R., Reiner Z., Riccardi G., Taskinen M.R., Tokgozoglu L., Verschuren W.M., Vlachopoulos C., Wood D.A., Zamorano J.L. 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias. Eur. Heart J. 2016;37(39):2999-3058.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Krenning G., Dankers P.Y., Drouven J.W., Waanders F., Franssen C.F., van Luyn M.J., Harmsen M.C., Popa E.R. Endothelial progenitor cell dysfunction in patients with progressive chronic kidney disease. Am. J. Physiol-Renal Physiol. 2009;296(6):1314</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Imig J.D., Ryan M.J. Immune and inflammatory role in renal disease. Comprehensive Physiol. 2013;3(2):957-76.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Vianna H.R., Soares C.M., Tavares M.S., Teixeira M.M., Silva A.C. Inflammation in chronic kidney disease: the role of cytokines. J. Bras. de Nefrol. 2011;33(3):351-64.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Wu K., Tian S., Zhou H., Wu Y. Statins protect human endothelial cells from TNF-induced inflammation via ERK5 activation. Bioch. Pharmacol. 2013;85(12):1753-60.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Loppnow H., Zhang L., Buerke M., Lautenschläger M., Chen L., Frister A., Schlitt A., Luther T., Song N., Hofmann B., Rose-John S., Silber R.E., Müller-Werdan U., Werdan K. Statins potently reduce the cytokine-mediated IL-6 release in SMC/MNC cocultures. J. Cell. Molec. Med. 2011;15(4):994-1004.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Siems W., Quast S., Carluccio F., Wiswedel I., Hirsch D., Augustin W., Kraemer K., Hampl H., Sommerburg O. Oxidative stress in chronic renal failure as a cardiovascular risk factor. Clin. Nephrol. 2002;58(1):12-9.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Mück A.O., Seeger H., Wallwiener D. Class-specific pro-apoptotic effect of statins on human vascular endothelial cells. Z. Kardiol. 2004;93(5):398-402.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Fried L.F., Orchard T.J., Kasiske B.L. Effect of lipid reduction on the progression of renal disease: a meta.analysis. Kidney Int. 2001;59(1):260-69.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Strippoli G.F., Navaneethan S.D., Johnson D.W., Perkovic V., Pellegrini F., Nicolucci A., Craig J.C. Effects of statins in patients with chronic kidney disease: meta-analysis and metaregression of randomised controlled trials. BMJ. 2008;336(7645):645-51.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Athyros V., Papageorgiou A., Mercouris B. Treatment with atorvastatin to the National Cholesterol Educational Program goal versus "usual" care in secondary coronary heart desease prevention. The GREACE study. Curr. Med. Res. Opin. 2002;18(4):220-28.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Isaacsohn J.L., Davidson M.H., Hunninghake D., Singer R., McLain R., Black D.M. Aggressive Lipid-Lowering Initiation Abates New Cardiac Events (ALLIANCE) - rationale and design of atorvastatin versus usual care in hypercholesterolemic patients with coronary artery disease. Am. J. Cardiol. 2000;86(2):250-52.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Wright J., Hutchison A. Cardiovascular disease in patients with chronic kidney disease Vasc. health and risk management. 2009; 5:713-22.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Locatelli F., Pozzoni P., Tentori F., del Vecchio L. Epidemiology of cardiovascular risk in patients with chronic kidney disease. Nephr. Dial. Transpl. 2003;18(7):2vii9.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Segall L., Nistor I., Covic A. Heart failure in patients with chronic kidney disease: a systematic integrative review. Bio. Med. Research. Int. 2014.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Takagi H., Umemoto T. Atorvastatin, not rosuvastatin, improves cardiac function in heart failure: a meta-analysis of randomized trials. Int. J. Cardiol. 2012;155(2):296-99.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Mozaffarian D., Nye R., Levy W. Statin therapy is associated with lower mortality among patients with severe heart failure. Am. J. Cardiol. 2004;93(9):1124-29.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Khush K.K., Waters D.D., Bittner V., Deedwania P.C., Kastelein J.J., Lewis S.J., Wenger N.K. Effect of high-dose atorvastatin on hospitalizations for heart failure. Circulation. 2007;115(5):576-83.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Scirica B.M., Morrow D.A., Cannon C.P., Ray K.K., Sabatine M.S., Jarolim P., Shui A., McCabe C.H., Braunwald E. Intensive statin therapy and the risk of hospitalization for heart failure after an acute coronary syndrome in the PROVE IT-TIMI 22 study. J. Am. Coll. Card. 2006;47(11):2326-31.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Kasama S., Toyama T., Sumino H., Kumakura H., Takayama Y., Minami K., Ichikawa S., Matsumoto N., Sato Y., Kurabayashi M. Prognostic value of cardiac sympathetic nerve activity evaluated by [123I] m-iodobenzylguanidine imaging in patients with ST-segment elevation myocardial infarction. Heart. 2011;97(1):20-6.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Tsutamoto T., Sakai H., Ibe K., Yamaji M., Kawahara C., Nakae I., Fujii M., Yamamoto T., Horie M. Effect of atorvastatin vs. rosuvastatin on cardiac sympathetic nerve activity in nondiabetic patients with dilated cardiomyopathy. Circ. J. 2011;75(9):2160-6.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Shepherd J., KasteleinJ.,Bittner V., Deedwania P., Breazna A., Dobson S., Wilson D.J., Zuckerman A., Wenger N.K. Treating to New Targets Investigators. Effect of intensive lipid lowering with atorvastatin on renal function in patients with coronary heart disease: the Treating to New Targets (TNT) study. Clin. J. Am. Soc. Nephrol. 2007;2(6):1131-39.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Бондар К.Ю., Белая О.Л., Лазутина О.М., Куроптева З.В., Байдер Л.М., Артамошина Н.Е., Яковлева Т.В. Гендерные особенности антиоксидантной защиты и эффективность аторвастатина у больных со стабильными формами ишемической болезни сердца. Клин. мед. 2017;5(95):398-403.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Shepherd J., Kastelein J.P., Bittner V.A., Deedwania P.C., Breazna A., Dobson S., Wilson D.J., Zuckerman A.L., Wenger N.K. Intensive lipid lowering with atorvastatin in patients with coronary artery disease, diabetes, and chronic kidney disease. Mayo Cli. Proc. 2008;83(8):870-79.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Ridker P.M., Rifai N., Stampfer M.J., Hennekens C.H. Plasma concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men. Circulation. 2000;101(15):1767-72. PMID:10769275.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Wahre T., Yundestat A., Smith C., Haug T., Tunheim S.H., Gullestad L., Froland S.S., Semb A.G., Aukrust P., Damås J.K. Increased Expression of Interleukin-1 in Coronary Artery Disease With Downregulatory Effects of HMG-CoA Reductase Inhibitors. Circulation. 2004;109(16):1966-72.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Schonebeck U., eVaro N., Libby P., Buring J., Ridker P.M. Soluble CD40L and cardiovascular risk in women. Circulation. 2001; 104:2266-68.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Kinlay S., Schwartz G.G., Olsson., Rifai N., Sasiela W.J., Szarek M., Ganz P., Libby P. Effect of atorvastatin on risk of recurrent cardiovascular events after an acute coronary syndrome associated with high soluble CD40 ligand in Myocardial Ischemia Reduction and Aggressive Cholesterol Lowering (MIRACL) Study. Circulation. 2004;110:386-91.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Blanco-Colio L.M., Tuhon J., Martln-Ventura J.L., Egido J. Anti-inflammatory and immunomodulatory effects of statins. Kidney Int. 2003;63(1);12-23.</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Charo I.F., Taub R. Anti-inflammatory therapeutics for the treatment of atherosclerosis Nature Rev. Drug Discovery. 2011;10(5):365-76.</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Popa C., Netea M.G., Van Riel P.L., van der Meer J.W., Stalenhoef A.F. The role of TNF-а in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk. J. Lip. Res. 2007;48(4):751-62.</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Bianchi S., Bigazzi R., Caiazza A., Campese V. A controlled, prospective study of the effects of atorvastatin on proteinuria and progression of kidney disease. Am. J. Kidney Dis. 2003;41(3):565-70.</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Bemelmans M.H., Gouma D.J., Buurman W.A. Influence of nephrectomy on tumor necrosis factor clearance in a murine model. J. Immunol. 1993;150(5):2007-17.</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Hession C., Decker J.M., Sherblom A.P., Kumar S., Yue C.C., Mattaliano R.J., Tizard R., Kawashima E., Schmeissner U., Heletky S., et al. Uromodulin (Tamm-Horsfall glycoprotein): A renal ligand for lymphokines. Science. 1987;237(4821):1479-84.</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Banyai S., Banyai M., Falger J., Jansen M., Alt E., Derfler K., Koppensteiner R. Atorvastatin improves blood rheology in patients with familial hypercholesterolemia (FH) on longterm LDL apheresis treatment. Atheroscleros. 2001;159:513-19.</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>Haque T., Khan B.V Atorvastatin: a review of its pharmacological properties and use in familial hypercholesterolemia. Clinical Lipidology. 2010;5(5):615-25.</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>Woodward M., Lowe G.D., Rumley A., Tunstall-Pedoe H. Fibrinogen as a risk factor for coronary heart disease and mortality in middle aged men and women. The Scottish Heart Health Study. Eur. Heart J. 1998;19:55-62.</mixed-citation></ref><ref id="B59"><label>59.</label><mixed-citation>Zheng C., Azcutia V., Aikawa E., Figueiredo J.L., Croce K., Sonoki H., Sacks F.M., Luscinskas F.W., Aikawa M. Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion. Eur. Heart J. 2013;34(8):615-24.</mixed-citation></ref><ref id="B60"><label>60.</label><mixed-citation>Ridker P.M., Cannon C.P., Morrow D.A., Rifai N., Kirtane A.J., McCabe C.H., Skene A.M., Gibson C.M., Ridker P.M., Braunwald E. for PROVE IT-TIMI22 Investigators. C-reactive protein levels and outcomes after statin therapy. N. Engl. J. Med. 2005;352(1):20-8.</mixed-citation></ref><ref id="B61"><label>61.</label><mixed-citation>Nissen S.E., Tuzcu E., Schoenhagen P., Crowe T., Sasiela W.J., Tsai J., Orazem J., Magorien R.D., O'Shaughnessy C., Ganz P. for REVERSAL Investigators. Statin Therapy, LDL Cholesterol, C-Reactive Protein, and Coronary Artery Disease. N. Engl. J. Med. 2005;352(1):2938.</mixed-citation></ref><ref id="B62"><label>62.</label><mixed-citation>Сусеков А.В., Рожкова Т.А., Трипотень М.И., Зубарева М.Ю., Рожкова Т.А., Погорелова О.А., Балахонова Т.В., Масенко В.П., Кухарчук В.В. Рандомизированное исследование ФАРВАТЕР. Часть 2. Влияние аторвастатина 10 и 20 мг/сут на функцию эндотелия, растяжимость и жесткость сосудистой стенки. Кардиология. 2007;2:25-30.</mixed-citation></ref><ref id="B63"><label>63.</label><mixed-citation>Беспалова И.Д., Калюжин В.В., Рязанцева Н.В., Медянцев Ю.А., Мурашев Б.И., Осихов И.А. Влияние 8-недельной терапии аторвастатином на качество жизни больных гипертонической болезнью с метаболическим синдромом. Артериальная гипертензии. 2013;19(2):125-31.</mixed-citation></ref><ref id="B64"><label>64.</label><mixed-citation>Кошельская О.А., Винницкая И.В., Конько Т.Ю., Кравченко Е.С., Суслова Т.Е., Карпов Р.С. Сравнительное рандомизированное исследование по оценке влияния длительной терапии розувастатином в сочетании с комбинацией аторвастатина и эзетимиба на показатели углеводного обмена и уровень адипокинов у больных ишемической болезнью сердца и сахарным диабетом 2 типа. Кардиология. 2015;3:67-74.</mixed-citation></ref><ref id="B65"><label>65.</label><mixed-citation>Соломенчук Т.Н., Семеген-Бодак К.В., Слаба Н.А., Чнгрян, Г.В., Мысышин М.Б. Проатерогенные метаболические нарушения при хронической болезни почек недиабетического генеза: возможности коррекции статинами. Кардиология. 2014;6:40-3.</mixed-citation></ref><ref id="B66"><label>66.</label><mixed-citation>Скорюкова С.А., Ким М.В., Быстрова А.А., Баранова Е.И., Пчелина С.Н. Полиморфизм S19W гена аполипопротеина А5 и эффективность терапии аторвастатином и фенофибратом у больных сахарным диабетом 2-го типа. Артериальная гипертензия. 2015;21(6):595-603.</mixed-citation></ref><ref id="B67"><label>67.</label><mixed-citation>Wang Y., Qiu X., Lv L., Wang C., Ye Z., Li S., Liu Q., Lou T., Liu X. Correlation between Serum Lipid Levels and Measured Glomerular Filtration Rate in Chinese Patients with Chronic Kidney Disease. Cheng X, ed. PLoS ONE. 2016;11(10):e0163767.</mixed-citation></ref><ref id="B68"><label>68.</label><mixed-citation>Widiasta A., Pardede S.O., Rachmadi D. Correlation between LDL, HDL, Total Cholesterol, and Triglyceride with the Degree of Chronic Kidney Disease in Children. Am. J. Clin. Med. Res. 2017;5(1):1-5.</mixed-citation></ref><ref id="B69"><label>69.</label><mixed-citation>Masse I., Bordet R., Deplanque D., Al Khedr A., Richard F., Libersa C., Pasquier F. Lipid lowering agents are associated with a slower cognitive decline in Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 2005.76(12). 1624-29.</mixed-citation></ref><ref id="B70"><label>70.</label><mixed-citation>Colhoun H.M., Betteridge D.J., Durrington P.N., Hitman G.A., Neil H.A., Livingstone S.J., Thomason M.J., Mackness M.I., Charlton-Menys V., Fuller J.H. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet. 2004;364(9435): 685-96.</mixed-citation></ref><ref id="B71"><label>71.</label><mixed-citation>Sever P.S., Dahlöf B., Poulter N.R., Wedel H., Beevers G., Caulfield M., Collins R., Kjeldsen S.E., Kristinsson A., McInnes G.T., Mehlsen J., Nieminen M., O'Brien E., Ostergren J. ASCOT Investigators. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet. 2003;361:1149-58.</mixed-citation></ref><ref id="B72"><label>72.</label><mixed-citation>Sever P., Dahlöf B., Poulter N., Wedel H., Beevers G., Caulfield M., Collins R., Kjeldsen S., Kristinsson A., McInnes G., Mehlsen J., Nieminem M., O'Brien E., Ostergren J. ASCOT Steering Committee Members. Potential synergy between lipid-lowering and blood-pressure-lowering in the Anglo Scandinavian Cardiac Outcomes Trial. Eur. Heart J. 2006;27(24):2982-88.</mixed-citation></ref><ref id="B73"><label>73.</label><mixed-citation>Schwartz G.G., Olsson A.G., Ezekowitz M.D., Ganz P., Oliver M.F., Waters D., Zeiher A., Chaitman B.R., Leslie S., Stern T. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes. The MIRACL Study: a randomized controlled trial. JAMA. 2001;285:1711-18.</mixed-citation></ref><ref id="B74"><label>74.</label><mixed-citation>Оганов Р.Г., Аронов Д.М., Бубнова М.Г. Применение статинов - парадигма профилактики и лечения атеросклеротиче ских заболеваний (фокус на аторвастатин). Кардиоваск. терапия и профилактика. 2006;6:95-107.</mixed-citation></ref><ref id="B75"><label>75.</label><mixed-citation>Wanner C., Tonelli M. KDIGO Clinical Practice Guideline for Lipid Management in CKD: summary of recommendation statements and clinical approach to the patient. Kidney Int. 2014;85(6):1303-309.</mixed-citation></ref><ref id="B76"><label>76.</label><mixed-citation>Mancia G., Fagard R., Narkiewicz K., Redon J., Zanchetti A., Böhm M., Christiaens T., Cifkova R., De Backer G., Dominiczak A., Galderisi M., Grobbee D.E., Jaarsma T., Kirchhof P., Kjeldsen S.E., Laurent S., Manolis A.J., Nilsson P.M., Ruilope L.M., Schmieder R.E., Sirnes P.A., Sleight P., Viigimaa M., Waeber B., Zannad F. 2013 ESH/ESCguidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur. Heart J. 2013;34(28):2159-219.</mixed-citation></ref><ref id="B77"><label>77.</label><mixed-citation>American Diabetes Association. Standards of medical care in diabetes - 2013. Diabetes care. 2013;36(1):11-66.</mixed-citation></ref><ref id="B78"><label>78.</label><mixed-citation>Pliquett R.U., Cornish K.G., Zucker I.H. Statin therapy restores sympathovagal balance in experimental heart failure. J. Appl. Physiol. 2003;95(2):700-4.</mixed-citation></ref><ref id="B79"><label>79.</label><mixed-citation>Van der Harst P., Wagenaar L.J., Buikema H., Voors A.A., Plokker H.W., Morshuis W.J., Six A.J., Boonstra P.W., Nickenig G., Wassmann S., van Veldhuisen D.J., van Gilst W.H. Effect of intencive versus moderate lipid lowering on endothelial function and vascular responsiveness to angiotensin II in stable coronary artery disease. Am. J. Cardiol. 2005;96(10):1361-64.</mixed-citation></ref><ref id="B80"><label>80.</label><mixed-citation>Pavlovic J., Greenland P., Deckers J.W., Brugts J.J., Kavousi M., Dhana K., Ikram M.A., Hofman A., Stricker B.H., Franco O.H., Leening M.J. Comparison of ACC/AHA and ESC Guideline Recommendations Following Trial Evidence for Statin Use in Primary Prevention of Cardiovascular DiseaseResults From the Population-Based Rotterdam Study. JAMA. Cardiol. 2016;1(6):708-13.</mixed-citation></ref><ref id="B81"><label>81.</label><mixed-citation>Ridker P.M., Danielson E., Fonseca F.A., Genest J., Gotto A.M. Jr., Kastelein J.J., Koenig W., Libby P., Lorenzatti A.J., MacFadyen J.G., Nordestgaard B.G., Shepherd J., Willerson J.T., Glynn R.J. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. New Engl. J. Med. 2008;359:2195-207.</mixed-citation></ref><ref id="B82"><label>82.</label><mixed-citation>Tendolkar I., Enajat M., Zwiers M.P., van Wingen G., de Leeuw F.E., van Kuilenburg J., Bouwels L., Pop G., Pop-Purceleanu M. One-year cholesterol lowering treatment reduces medial temporal lobe atrophy and memory decline in stroke-free elderly with atrial fibrillation: evidence from a parallel group randomized trial. Int. J. Geriatr. Phychiatry. 2012;27(1):49-58.</mixed-citation></ref><ref id="B83"><label>83.</label><mixed-citation>März W., Genser B., Drechsler C., Krane V., Grammer T.B., Ritz E., Stojakovic T., Scharnagl H., Winkler K., Holme I., Holdaas H., Wanner C. Atorvastatin and low-density lipoprotein cholesterol in type 2 diabetes mellitus patients on hemodialysis. Clin. J. Am. Soc. Nephrol. 2011;6(6):316-325.</mixed-citation></ref><ref id="B84"><label>84.</label><mixed-citation>Arvanitakis Z., Schneider J.A., Wilson R.S., Bienias J.L., Kelly J.F., Evans D.A., Bennett D.A. Statins, incident Alzheimer disease, change in cognitive function, and neuropathology. Neurology. 2008;70(19, 2):1795-802.</mixed-citation></ref><ref id="B85"><label>85.</label><mixed-citation>Beck M. Can a drug that helps hearts be harmful to the brain? Wall Street J. 2008 February 12 (Available at: http://online.wsj. com/public/us).</mixed-citation></ref><ref id="B86"><label>86.</label><mixed-citation>Barone E., Cenini G., Di Domenico F., Martin S., Sultana R., Mancuso C., Murphy M.P., Head E., Butterfield D.A. Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action. Pharmacol. Res. 2011;63(3):172-80.</mixed-citation></ref><ref id="B87"><label>87.</label><mixed-citation>Yan Y., Qiu B., Wang J., Deng S.B., Wu L., Jing X.D., Du J.L., Liu Y.J., She Q. High-intensity statin therapy in patients with chronic kidney disease: a systematic review and meta-analysis. BMJ. Open. 201;5: e006886.</mixed-citation></ref><ref id="B88"><label>88.</label><mixed-citation>Wu Y.L., Saver J.L., Chen P.C., Lee J.D., Wang H.H., Rao N.M., Lee M., Ovbiagele B. Effect of statin use on clinical outcomes in ischemic stroke patients with atrial fibrillation. Medicine. 2017;96(5):e5918.</mixed-citation></ref><ref id="B89"><label>89.</label><mixed-citation>Kostapanos M.S., Liberopoulos E.N., Goudevenous J.A., Mikhailidis D.P., Elisaf M.S. Do statins have an antiarrhythmic activity? Cardiovas. Res. 2007;75:10-20.</mixed-citation></ref><ref id="B90"><label>90.</label><mixed-citation>Pretorius M., Donahue B.S., Yu C., Greelish J.P., Roden D.M., Brown N.J. Plasminogen activator inhibitor-1 as a predictor of postoperative atrial fibrillation after cardiopulmonary bypass. Circulation. 2007;116(1):1-7.</mixed-citation></ref><ref id="B91"><label>91.</label><mixed-citation>Roik M., Starczewska M.H., Huczek Z. Statin therapy and mortality among patients hospitalized with heart failure and preserved left ventricular function - a preliminary report. Acta Cardiol. 2008;63(6):683-92.</mixed-citation></ref><ref id="B92"><label>92.</label><mixed-citation>Cho E. Y., Myoung C., Park H. S., Kim A.J., Ro H., Chang J.H., Lee H.H., Chung W., Jung J.Y. Efficacy of Statin Treatment in Early-Stage Chronic Kidney Disease. PloS One. 2017;12(1):e0170017.</mixed-citation></ref></ref-list></back></article>
