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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pharmateca</journal-id><journal-title-group><journal-title xml:lang="en">Pharmateca</journal-title><trans-title-group xml:lang="ru"><trans-title>Фарматека</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2073-4034</issn><issn publication-format="electronic">2414-9128</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">290029</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Case of SAPHO-syndrome -diagnosing path and experience of successive use of pamidronate</article-title><trans-title-group xml:lang="ru"><trans-title>Случай SAPHO-синдрома - диагностический путь и опыт успешного применения памидроната</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Novikov</surname><given-names>P. I</given-names></name><name xml:lang="ru"><surname>Новиков</surname><given-names>П. И</given-names></name></name-alternatives><bio xml:lang="en"><p>Head of the Rheumatological Department of UCH № 3, Teaching Assistant at the Department of Internal, Occupational Diseases and Pulmonology MPF</p></bio><bio xml:lang="ru"><p>зав. ревматологическим отделением УКБ № 3, ассистент кафедры внутренних, профессиональных болезней и пульмонологии МПФ</p></bio><email>novikov-pavel@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Makarov</surname><given-names>E. A</given-names></name><name xml:lang="ru"><surname>Макаров</surname><given-names>Е. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zykova</surname><given-names>A. S</given-names></name><name xml:lang="ru"><surname>Зыкова</surname><given-names>А. С</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Moiseyev</surname><given-names>S. V</given-names></name><name xml:lang="ru"><surname>Моисеев</surname><given-names>С. В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">FSAEI HE I.M. Sechenov First Moscow State Medical University MHRF (Sechenov University)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава России (Сеченовский Университет)</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-10-10" publication-format="electronic"><day>10</day><month>10</month><year>2017</year></pub-date><volume>24</volume><issue>19</issue><issue-title xml:lang="en">NO19 (2017)</issue-title><issue-title xml:lang="ru">№19 (2017)</issue-title><fpage>25</fpage><lpage>30</lpage><history><date date-type="received" iso-8601-date="2023-02-26"><day>26</day><month>02</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, ООО «Бионика Медиа»</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2073-4034/article/view/290029">https://journals.eco-vector.com/2073-4034/article/view/290029</self-uri><abstract xml:lang="en"><p>SAPHO syndrome is an extremely rare disease with an unknown etiology, affecting the musculoskeletal system with the formation of osteitis and hyperostosis, as well as affecting the skin. Its place in the classification of rheumatological diseases, as well as the algorithm of therapy requires clarification. The article presents a clinical observation with a literature review.</p></abstract><trans-abstract xml:lang="ru"><p>Синдром SAPHO - крайне редкое заболевание с неясной этиологией, поражающее опорно-двигательный аппарат с формированием остеитов и гиперостозов, а также кожные покровы. Его место в классификации ревматологических болезней требует уточнения, как и алгоритм терапии. В статье представлено клиническое наблюдение с обзором литературы.</p></trans-abstract><kwd-group xml:lang="en"><kwd>SAPHO syndrome</kwd><kwd>skin syndrome</kwd><kwd>musculoskeletal disorders</kwd><kwd>pamidronate</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>синдром SAPHO</kwd><kwd>кожный синдром</kwd><kwd>патология опорно-двигательного аппарата</kwd><kwd>памидронат</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Aljuhani F., Toumadre A., Tatar Z., Couderc M., Mathieu S., Malochet-Guinamand S., Soubrier M., Dubost J. J. The SAPHO syndrome: a singlecenter study of 41 adult patients. J. Rheumatol. 2015;42:2:329-34.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Hayem G., Bouchaud-Chabot A., Benali K., Roux S., Palazzo E., Silbermann-Hoffman O., Kahn M.F., Meyer O. SAPHO syndrome: a long-term follow-up study of 120 cases. Semin. 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