PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media290030ArticlesСтатьиResearch ArticleVisual disturbances and Alzheimer’s diseaseЗрительные нарушения и болезнь АльцгеймераBogolepovaA. NБоголеповаА. Н

MD, Prof. at the Department of Neurology, Neurosurgery and Medical Genetics of the Medical Faculty

д.м.н., проф. кафедры неврологии, нейрохирургии и медицинской генетики лечебного факультета

annabogolepova@yandex.ruMakhnovichE. VМахновичЕ. ВZhuravlevaA. NЖуравлеваА. НDonskikhT. AДонскихТ. АFSBEI HE RNSMU n.a. N.I. Pirogov of RMHФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава РоссииFSBEI “Moscow Scientific Research Institute of Eye Diseases n.a. Helmholtz" of RMHФГБОУ «Московский научно-исследовательский институт глазных болезней им. Гельмгольца» Минздрава РоссииSBHCI “City Polyclinic № 212" of Moscow Healthcare DepartmentГБУЗ «Городская поликлиника 212» ДЗ Москвы101020172419NO19 (2017)№19 (2017)313626022023Copyright ©; 2017, Bionika MediaCopyright ©; 2017, ООО «Бионика Медиа»2017Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2073-4034/article/view/290030

This article presents an analytical overview of possible prospects for the diagnosis of Alzheimer’s disease (AD) using optical coherence tomography. The urgency of this problem is determined by the steady increase in the number of patients suffering from dementia, in whom 60-80% of cases of dementia are caused by AD. Data on the structural and functional changes in the visual analyzer in AD are discussed. The problem of preclinical diagnosis of AD using optical coherence tomography (OCT) is considered as an actual problem. OCT is a non-invasive method of intravital examination, allowing to obtain a cross-sectional image of the tissue. The available literature data interpret the parameters of the retinal OCT imaging as a potential biomarker of the early stage of AD.

В данной статье представлен аналитический обзор о возможных перспективах диагностики болезни Альцгеймера (БА) с помощью оптической когерентной томографии. Актуальность этой проблемы определяется неуклонным ростом численности больных, страдающих деменцией, у которых 60-80% случаев деменции обусловлены БА. Приводятся данные о структурных и функциональных изменениях в зрительном анализаторе при БА. В качестве актуальной рассматривается проблема доклинической диагностики БА с помощью оптической когерентной томографии (ОКТ). ОКТ - неинвазивный метод прижизненного исследования, с помощью которого получают изображение поперечного среза исследуемой ткани. Имеющиеся в литературе данные трактуют параметры ОКТ сетчатки как потенциальный биомаркер ранней стадии БА.

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