PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media290031ArticlesСтатьиResearch ArticleModern approaches to treatment of osteoarthritis: the role of injectable slow-acting symptom-modifiing preparationsСовременные подходы к лечению остеоартрита: роль инъекционных медленнодействующих симптом-модифицирующих препаратовChichasovaN. VЧичасоваН. В

MD, Prof. at the Department of Rheumatology

д.м.н., проф. кафедры ревматологии

kafedrarheum@yandex.ruFSAEI HE I.M. Sechenov First Moscow State Medical University MHRF (Sechenov University)ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава России (Сеченовский Университет)101020172419NO19 (2017)№19 (2017)374326022023Copyright ©; 2017, Bionika MediaCopyright ©; 2017, ООО «Бионика Медиа»2017Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2073-4034/article/view/290031

The article discusses the causes of pain in osteoarthritis (OA), the role of inflammation in the pathogenesis of the disease, and the limitation of the use of nonsteroidal anti-inflammatory drugs (NSAIDs). The current international recommendations 2014 and 2016, according to which treatment of OA is recommended to start with slow-acting symptom-modifying drugs (SYSADOA - Symptomatic Slow-Acting Drugs in Osteoarthritis), are presented. Data on analgesic and anti-inflammatory effects of chondroitin sulfate (ChS), and its safety are given. It is shown that it is possible to achieve a more rapid effect when using the injectable dosage form of ChS. Data on the mechanism of action, safety and efficacy of hyaluronic acid preparations are discussed.

В статье обсуждаются причины боли при остеоартрите (ОА), роль воспаления в патогенезе заболевания и ограничения применения нестероидных противовоспалительных средств (НПВС). Освещаются современные международные рекомендации 2014 и 2016 гг., в соответствии с которыми лечение ОА рекомендовано начинать с медленнодействующих симптом-модифицирующих препаратов (SYSADOA - Symptomatic Slow-Acting Drugs in Osteoarthritis). Приведены данные об анальгетическом и противовоспалительном действиях хондроитин сульфата (ХС), о его безопасности. Показано, что достичь более быстрого эффекта возможно при применении инъекционной формы ХС. Приведены данные о механизме действия, безопасности и эффективности препаратов гиалуроновой кислоты

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