PharmatecaPharmatecaФарматека2073-40342414-9128Bionika Media290032ArticlesСтатьиResearch ArticleAntiresorptive-cytocin efficiency of chondroprotective therapy of osteoarthritis and non-specific low back pain (results of ALBATROS study)Антирезорбтивно-цитокиновая эффективность хондропротективной терапии остеоартрита и неспецифической боли в спине (результаты исследования АЛЬБАТРОС)ZolotovskayaI. AЗолотовскаяИ. А

PhD, Teaching Assistant at the Department of Hospital Therapy with Courses of Outpatient Therapy and Transfusiology

к.м.н., ассистент кафедры госпитальной терапии с курсами поликлинической терапии и трансфузиологии

zolotovskay@list.ruDavydkinI. LДавыдкинИ. ЛFSBEI HE "Samara State Medical University" of RMHФГБОУ ВО «Самарский государственный медицинский университет» Минздрава России101020172419NO19 (2017)№19 (2017)445226022023Copyright ©; 2017, Bionika MediaCopyright ©; 2017, ООО «Бионика Медиа»2017Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2073-4034/article/view/290032

The article presents the results of the ALBATROS study, the purpose of which was to evaluate the antiresorptive-cytokine efficacy of chondroprotective therapy for osteoarthritis (OA) and non-specific lower back pain. The study showed that patients with OA and low back pain have elevated levels of cytokines and markers of bone resorption as a reflection of a single pathophysiological mechanism of damage to the musculoskeletal joint tissue. During the entire period of observation, positive dynamics with respect to decrease in resorption marker levels against the background of chondroprotective therapy with Alflutop was noted and statistically confirmed. The obtained results allow to consider chondroprotective therapy in the strategy of treatment of OA patients and low back pain in terms of its antiresorptive-cytokine efficacy.

Представлены результаты исследования АЛЬБАТРОС, целью которого стала оценка антирезорбтивно-цитокиновой эффективности хондропротективной терапии остеоартроза (ОА) и неспецифической боли в нижней части спины. Проведенное исследование показало, что пациенты с ОА и болью в спине имеют повышенные уровни цитокинов и маркеров костной резорбции как отражение единого патофизиологического механизма повреждения костно-мышечно-суставной ткани. За весь период наблюдения отмечена и статистически подтверждена положительная динамика в отношении снижения маркеров резорбции на фоне хондропротективной терапии Алфлутопом. Полученные результаты позволяют рассматривать хондропротективную терапию в стратегии лечения больных ОА и болью в спине с точки зрения ее антирезорбтивно-цитокиновой эффективности.

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